Biofilm formation relies as much on bacterial adhesion properties than on surface chemistry, and many questions remain regarding biophysics of surface adhesion. In collaboration with physico-chemists and biophysicists, we used multidisciplinary approaches to investigate bacterial adaptations to surface contact and biomechanical properties of adhesins.
Recent articles on this topic
• Khanal, M.*, F. Larsonneur*, V. Raks, A. Barras, J.-S. Baumann, F.A. Martin, R. Boukherroub, J.M. Ghigo, C. Ortiz Mellet, V. Zaitsev, J.M. Garcia Fernandez, C. Beloin ¶, A..Siriwardena ¶, and S. Szunerits ¶. (2015). Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles. Nanoscale Feb 14;7(6): 2325-35. * Equal contribution; ¶co-corresponding authors
• Jacquot, A., C. Sakamoto, A. Razafitianamaharavo, C. Caillet, J. Merlin, A. Fahs, J.M. Ghigo, J.F. Duval,; C. Beloin, and G. Francius. (2014)..The dynamics and pH-dependence of Ag43 adhesins self-association probed by Atomic Force Spectroscopy. Nanoscale Oct. 9;6(21):12665-81. doi: 10.1039.
Review on this topic
• Catherine Even, Christian Marlière, Jean-Marc Ghigo, Jean-Marc Allain, Alba Marcellan, Eric Raspaud. Recent advances in studying single bacteria and biofilm mechanics. (2017). Advances in Colloids and Interface science. Sep;247:573-588. doi: 10.1016/j.cis.2017.07.026.