Understanding the molecular basis of host-pathogen interactions is critical for the discovery of new therapeutic approaches to treat infectious diseases, which in the face of increasing antibiotic resistance and emerging pathogens, is a major priority medical research in Europe. Studying the signalling pathways in immune cells during infection also gives us fundamental information about the mechanisms of immune cell activation during inflammation that is relevant for other human diseases including autoimmune disease, cardiovascular disease and even cancer. With this grant we focus on the process of components of the macroautophagy machinery within macrophages that are infected with bacterial pathogens, and we put it into relation with innate immune signaling. At the Institut Pasteur, we are collaborating with the team of Robert Weil on this project. It is coordinated by Toby Lawrence at the CIML in Marseille.