Besides their major role in many infectious diseases, bacteria also serve as models to understand fundamental biological mechanisms. The research performed in the Department of Microbiology mainly focuses on the molecular characterization of functions that enable bacteria to interact with their environment and, in some cases, to cause diseases.

The scientists of the Department of Microbiology study various bacteria and Archaea (and their viruses) as model systems to analyze fundamental biological processes at the population, cellular and molecular levels. They also focus on mechanisms rendering some of these microorganisms virulent and enabling them to evade the host immune system, or to develop resistance to antibiotics. For these studies, the scientists of the Department of Microbiology possess a wide range of expertise and use diverse integrative approaches to improve our understanding of the biology of these microorganisms. These  studies also constitute a prerequisite for the development of new therapies or new diagnostic tools that can be used to treat or prevent bacterial infections. The Department of Microbiology includes 20 teams: 15 research teams, 1 Institut Pasteur/Paris University laboratory, and 4 collections. Three entities also host a National Reference Center and 2 are WHO Collaborating Centers. In addition, several research teams from other departments (Genomes & Genetics, Structural Biology and Chemistry and Infection & Epidemiology) are affiliated to the Department of Microbiology. The Department also hosts a joint research entity with the CNRS (French National Center for Scientific Research) – UMR2001.

Bernal-Bayard J, Thiebaud J, Brossaud MJ, Beaussart A, Caillet C, Waldvogel Y, Travier L,Létoffé S, Fontaine T, Rokbi B, Talaga P, Beloin C., Mistretta N*, Duval JFL*, Ghigo JM*. (2023) Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties. Nature Communications, May 3;14(1):2553. doi: 10.1038/s41467-023-37925-8. .

Pavao A, Girinathan B, Peltier J, Altamirano Silva P, Dupuy B, Muti IH, Malloy C, Cheng LL, Bry L.  (2023) Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale modeling. Nat. Chem. Biology Mar 9. doi: 10.1038/s41589-023-01275-9. PMID: 36894723.

Rostain W, Grebert T, Vyhovskyi D, Pizarro PT, Tshinsele-Van Bellingen G, Cui L, Bikard D. (2023). Cas9 off-target binding to the promoter of bacterial genes leads to silencing and toxicity. Nucleic Acids Res. Apr 24;51(7):3485-3496. doi: 10.1093/nar

Schator D, Mondino S, Berthelet J, Di Silvestre C, Ben Assaya M, Rusniok C, Rodrigues-Lima F, Wehenkel A, Buchrieser C, Rolando M. Legionella para-effectors target chromatin and promote bacterial replication. (2023). Nature Communications. Apr 14;14(1):2154. doi:

El Khoury JY, Zamarreño Beas J, Huguenot A, Py B, Barras F. .Bioenergetic State of Escherichia coli Controls Aminoglycoside Susceptibility. (2023).mBio. Feb 28;14(1):e0330222. doi: 10.1128/mbio.03302-22.


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