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Besides their major role in many infectious diseases, bacteria also serve as models to understand fundamental biological mechanisms. The research performed in the Department of Microbiology mainly focuses on the molecular characterization of functions that enable bacteria to interact with their environment and, in some cases, to cause diseases.

The scientists of the Department of Microbiology study various bacteria and Archaea (and their viruses) as model systems to analyze fundamental biological processes at the population, cellular and molecular levels. They also focus on mechanisms rendering some of these microorganisms virulent and enabling them to evade the host immune system, or to develop resistance to antibiotics. For these studies, the scientists of the Department of Microbiology possess a wide range of expertise and use diverse integrative approaches to improve our understanding of the biology of these microorganisms. These  studies also constitute a prerequisite for the development of new therapies or new diagnostic tools that can be used to treat or prevent bacterial infections. The Department of Microbiology includes 20 teams: 15 research teams, 1 Institut Pasteur/Paris University laboratory, and 4 collections. Three entities also host a National Reference Center and 2 are WHO Collaborating Centers. In addition, several research teams from other departments (Genomes & Genetics, Structural Biology and Chemistry and Infection & Epidemiology) are affiliated to the Department of Microbiology. The Department also hosts a joint research entity with the CNRS (French National Center for Scientific Research) – UMR2001.

  • Kumar, S., Schmitt, C., Gorgette, O., Marbouty, M., Duchateau, M., Giai Gianetto, Q., Matondo, M., Guigner, J. M., & De Reuse, H. (2022). Bacterial Membrane Vesicles as a Novel Strategy for Extrusion of Antimicrobial Bismuth Drug in Helicobacter pylori. mBio, 13(5), e0163322.
  • Klunk J, Vilgalys TP, Demeure CE, Cheng X, Shiratori M, Madej J, Beau R, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux R, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Rouleau GA, Steinrücken M, Pizarro-Cerdá J, Poinar HN, Barreiro LB, (2022), Evolution of immune genes is associated with the Black Death., Nature 2022 Nov; 611(7935): 312-319. doi:10.1038/s41586-022-05349-x
  • Garcia PS, D’Angelo F, Ollagnier de Choudens S, Dussouchaud M, Bouveret E, Gribaldo S, Barras F, (2022), An early origin of iron-sulfur cluster biosynthesis machineries before Earth oxygenation, Nat Ecol Evol 2022 Oct;6(10):1564-1572. doi: 10.1038/s41559-022-01857-1
  • Rousset,F., Depardieu,F., Miele,S., Dowding,J., Laval,A.-L., Lieberman,E., Garry,D., Rocha,E.P.C., Bernheim,A. and Bikard,D. (2022) Phages and their satellites encode hotspots of antiviral systems. Cell Host & Microbe, 0. doi: 10.1016/j.chom.2022.02.018
  • Lourenço M, Chaffringeon L, Lamy-Besnier Q, Titécat M, Pédron T, Sismeiro O, Legendre R, Varet H, Coppée JY, Bérard M, De Sordi L, Debarbieux L, (2022), The gut environment regulates bacterial gene expression which modulates susceptibility to bacteriophage infection, Cell Host Microbe 2022 Apr 13;30(4):556-569.e5. doi: 10.1016/j.chom.2022.03.014
  • Wang F, Cvirkaite-Krupovic V, Vos M, Beltran LC, Kreutzberger MAB, Winter JM, Su Z, Liu J, Schouten S, Krupovic M, Egelman EH, (2022Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome., Cell 2022 Apr; 185(8): 1297-1307.e11. doi: 10.1016/j.cell.2022.02.019
  • Bechon N, Mihajlovic J, Lopes A.A I, Sol Vendrell-Fernandez S; Deschamps J, Briandet R, Sismeiro O, Martin-Verstraete I, Dupuy B and Ghigo JM. (2022). Bacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation.  Proc Natl Acad Sci U S A Feb 15;119(7):e2111228119 doi: 10.1073/pnas.2111228119
  • Sahr T, Escoll P, Rusniok C, Bui S, Pehau-Arnaudet G, Lavieu G, Buchrieser C, (2022), Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response., Nat Commun 2022 Feb; 13(1): 762. doc: 10.1038/s41467-022-28454-x



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