Besides their major role in many infectious diseases, bacteria also serve as models to understand fundamental biological mechanisms. The research performed in the Department of Microbiology mainly focuses on the molecular characterization of functions that enable bacteria to interact with their environment and, in some cases, to cause diseases.
The scientists of the Department of Microbiology study various bacteria and Archaea (and their viruses) as model systems to analyze fundamental biological processes at the population, cellular and molecular levels. They also focus on mechanisms rendering some of these microorganisms virulent and enabling them to evade the host immune system, or to develop resistance to antibiotics. For these studies,the scientists of the Department of Microbiology possess a wide range of expertise and use diverse integrative approaches to improve our understanding of the biology of these microorganisms. These studies also constitute a prerequisite for the development of new therapies or new diagnostic tools that can be used to treat or prevent bacterial infections.
The Department of Microbiology includes 20 teams: 13 research teams, 1 Institut Pasteur/Paris 7 University laboratory, 2 junior groups (G5) and 4 collections. Three entities also host a National Reference Center and 2 are WHO Collaborating Centers. In addition, several research teams from other departments (Genomes & Genetics, Structural Biology and Chemistry and Infection & Epidemiology) are affiliated to the Department of Microbiology. The Department also hosts a joint research entity with the CNRS (French National Center for Scientific Research) – ERL6002.
•Kazlauskas D, Varsani A, Koonin EV, Krupovic M.(2019).Multiple origins of prokaryotic and eukaryotic single-stranded DNA viruses from bacterial and archaeal plasmids.Nat Commun. 2019 Jul 31;10(1):3425
• López-Igual, R., Bernal-Bayard, J., Rodríguez-Patón, A., Ghigo, J.M., and Didier Mazel.(2019). Engineering synthetic toxin-intein weapons as specific antimicrobials Nature Biotechnology. April 15. https://doi.org/10.1038/s41587-019-0105-3
• Gomez-Valero L, Rusniok C, Carson D, Mondino S, Pérez-Cobas AE, Rolando M, Pasricha S, Reuter S, Demirtas J, Crumbach J, Descorps-Declere S, Hartland EL, Jarraud S, Dougan G, Schroeder GN, Frankel G, Buchrieser C. (2019). More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells. Proc. Natl. Acad. Sci. U.S.A. 2019 Jan;