One of the most prominent features of archaea is the extraordinary diversity of their DNA viruses. Many archaeal viruses differ substantially in morphology from bacterial and eukaryotic viruses and represent unique virus families. For instance, viruses with bottle-shaped, lemon-shaped, coil-shaped or droplet-shaped virions are thus far exclusive to the Archaea. The distinct nature of archaeal viruses also extends to the gene composition and architectures of their genomes, and the properties of the proteins that they encode. Environmental research has revealed prominent roles of archaeal viruses in influencing microbial communities in ocean ecosystems, and recent metagenomic studies have uncovered new groups of archaeal viruses that infect extremophiles and mesophiles in diverse habitats. We are exploring the extent of archaeal virus diversity in different habitats and different aspects of their biology, including virion structure and assembly, molecular mechanisms of their entry and egress as well as other aspects of virus-host interaction.
ANR-ENVIRA: Membrane remodeling by enveloped viruses of Archaea
Mart Krupovic (PI)
Membrane remodeling is a fundamental and necessary process underlying proper functioning of cellular organisms in all three domains of life. Much of our knowledge on the mechanisms of membrane fusion and scission, two of […]
2020Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire, Nat. Rev. Genet. 2020 Feb;21(2):119-131.
2020An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity, Nature 2020 Jan; doi: 10.1038/s41586-019-1909-5.
2020Phages build anti-defence barriers, Nat Microbiol 2020 Jan;5(1):8-9.
2019Virus-borne mini-CRISPR arrays are involved in interviral conflicts, Nat Commun 2019 Nov;10(1):5204.
2019A packing for A-form DNA in an icosahedral virus, Proc. Natl. Acad. Sci. U.S.A. 2019 Nov;116(45):22591-22597.
2019Diversification of giant and large eukaryotic dsDNA viruses predated the origin of modern eukaryotes, Proc. Natl. Acad. Sci. U.S.A. 2019 Sep;116(39):19585-19592.
2019Multiple origins of prokaryotic and eukaryotic single-stranded DNA viruses from bacterial and archaeal plasmids, Nat Commun 2019 Jul;10(1):3425.
2019Cryptic inoviruses revealed as pervasive in bacteria and archaea across Earth’s biomes, Nat Microbiol 2019 Nov;4(11):1895-1906.
2019Spindle-shaped viruses infect marine ammonia-oxidizing thaumarchaea, Proc. Natl. Acad. Sci. U.S.A. 2019 Jul 30;116(31):15645-15650.
2019Origin of programmed cell death from antiviral defense?, Proc. Natl. Acad. Sci. U.S.A. 2019 Aug 13;116(33):16167-16169.
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