Developmental biology first made its appearance in the Pasteur Institute when François Jacob and François Gros with their colleagues became interested in extending their pioneering work on messenger RNA in bacteria to gene regulation in eukaryotic systems.
This led to the introduction of mouse genetics and embryology and to work on differentiating cells in culture.
Initially these and other research groups were part of the Molecular Biology Department in the Jacques Monod building, which opened at the end of the 1960s, after the award of the Nobel prize to Jacob, Monod and Lwoff.
Scientific research and communal activities
The Department of Developmental Biology was created in 2001, and includes the descendants of the original laboratories in the Jacques Monod building, as well as others which have joined the Institute. Today research in the Department converges on two main poles of interest.
One concerns the regulation of gene expression in different developmental contexts, ranging from molecular studies on transcription factors and chromatin structure to the analysis of phenotypes when regulatory genes are mutated. The other focusses on cell lineages and cell behaviour in the embryo, with an interest also in the progenitor cells of adult tissues.
In a biomedical context, with an interface with other departments on the campus, these developmental studies have led to work on stem cells with a potential for tissue regeneration and to the creation of a number of mouse models for human disease.
The Department has a strong tradition in genetics, both in classical genetics and in gene manipulation in the mouse. This is reflected by the presence of veterinarians responsible for the mouse facilities of the Institute, and the transgenic mouse service, which is also attached to our Department.
Our colleagues also include human geneticists and a group using Drosophila genetics. The mouse is the model organism studied by most laboratories. However, in addition to Drosophila, there are groups working with zebra fish, and the chick embryo is also used. Precise information about research activities is given under each Unit or Group.
Research units in the DSCB Department have published over 250 research articles and over 70 reviews in the last 5 years (Cell, Cell Stem Cell, Developmental Cell, Cell Host Microbe, N Engl J Med, Nature, Nature Medicine, Nature Cell Biology, Nature Struc. Mol. Biology, Nature Communications, Nature Methods, Nature Protocols, Science, Science Signaling, J. Exp. Medicine, Genes & Development, Blood, PNAS, EMBO J, PloS Biology, Development)
Recent distinctions include:
- Laure Bally-Cuif: ERC Advanced Grant (2012), EMBO member (2016)
- Margaret Buckingham: CNRS Gold Medal (2013)
- Germano Cecere: ERC Starting Grant (2015)
- Ken McElreavey: French National Academy of Medicine prize (2011)
- Elisa Gomez-Perdiguero: Paoletti prize (2015), ERC Starting Grant (2016)
- Jerôme Gros: ERC starting Grant (2013), Paoletti prize (2013), EMBO Young Investigator Programme (2016)
- François Spitz: EMBO member (2016)
- François Schweisguth: EMBO member (2012), C.-L. Mayer prize (2015)
- Shahragim Tajbakhsh: EMBO member (2012), ERC Advanced Grant (2012), Academy of Sciences/Fondation de France prize for research on stem cells (2014)
PIs emerging from the DSCB Department
Several senior researchers obtained independent group leader positions since 2009
- Ramkumar Sambasivan (2012) – Group Leader, inStem, Bangalore, India
- Colin Crist (2013) – Assistant Professor, McGill University, Canada
- Karima Kissa (2013) – Group leader (CNRS ATIP-Avenir), University of Montpellier
- Milka Sarris (2014) – MRC Research Fellow, University of Cambridge, UK
- Ute Rogner (2014) – Group Leader, Institut Cochin, Paris
- Sigolène Meilhac (2014) – Group Leader, Institut Pasteur/Necker Hospital, Paris
Recent recruitments of G5 junior group leaders
- Pauline Spéder (from Cambridge, UK) recruited May 2015
- Elisa Gomez Perdiguero (from King’s College, London) recruited April 2015
- Germano Cecere (from Columbia University), recruited September 2015
- Romain Levayer (from Bern University), recruited December 2016