Developmental biology first made its appearance in the Pasteur Institute when François Jacob and François Gros with their colleagues became interested in extending their pioneering work on messenger RNA in bacteria to gene regulation in eukaryotic systems. This led to the introduction of mouse genetics and embryology and to work on differentiating cells in culture. Initially these and other research groups were part of the Molecular Biology Department in the Jacques Monod building, which opened at the end of the 1960s, after the award of the Nobel prize to Jacob, Monod and Lwoff. The Department of Developmental Biology was then created in 2001. Its name was changed into the Department of Developmental and Stem Cell Biology in 2014 to recognize the advent of stem cell research in the context of living organisms with the support from the Labex REVIVE.
Today research in the Department converges on three main poles of interest. One concerns the regulation of gene expression, ranging from molecular studies on transcription factors to epigenomics. The other focusses on cell lineages, cell fate and cell behaviour in the embryo, with an interest on morphogenesis and organogenesis. A third pole of interest concerns the biology of stem cells, particularly in the context of tissue regeneration and disease modeling.
Various model organisms (mouse, zebrafish, chick, quail, fly, nematode, sea anemona) are used. Precise information about research activities is given under each Unit or Group.
Recent distinctions :
- Laure Bally-Cuif: ERC Advanced Grant (2012), EMBO member (2016), French National Academy of Medicine prize (2016), CNRS Silver Medal (2017)
- Margaret Buckingham: CNRS Gold Medal (2013)
- Germano Cecere: ERC Starting Grant (2015)
- Ken McElreavey: French National Academy of Medicine prize (2011)
- Elisa Gomez-Perdiguero: Paoletti prize (2015), ERC Starting Grant (2016)
- Jerôme Gros: ERC starting Grant (2013), Paoletti prize (2013), EMBO Young Investigator Programme (2016)
- François Spitz: EMBO member (2016)
- François Schweisguth: EMBO member (2012), C.-L. Mayer prize (2015)
- Shahragim Tajbakhsh: EMBO member (2012), ERC Advanced Grant (2012), Academy of Sciences/Fondation de France prize for research on stem cells (2014)
Recent recruitments :
- Pauline Spéder (from Cambridge, UK) recruited May 2015
- Elisa Gomez Perdiguero (from King’s College, London) recruited April 2015
- Germano Cecere (from Columbia University), recruited September 2015
- Romain Levayer (from Bern University), recruited December 2016