Biofilms are communities of microorganisms that interact with surfaces, and are known to display unique properties that differentiate them from free-floating, individual microorganisms. While biofilms are widespread and play many positive roles in all environments, they are also difficult to eradicate when adhered to surfaces in medical and industrial settings.We use genetics, genomics, molecular biology, and various in vitro and in vivo biofilm models to better understand biofilm-associated functions used by commensal and pathogenic bacteria. We also attempt to translate our fundamental approaches into relevant anti-biofilm strategies in collaboration with clinicians and industrial partners.
Stressmann F*, Bernal-Bayard J*, Pérez-Pascual D, Audrain B, Rendueles O, Briolat V, Bruchmann S, Volant S, Ghozlane A, Haussler S, Duchaud E, Levraud JP, Ghigo JM. Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection.The ISME Journal, in press (*co-first authors)
Pérez-Pascual D, Estellé-Fabrellas J, Dutto G, Rodde C, Bernardet JF, Marchand Y, Duchaud E, Przybyla C*, Ghigo JM* (2020) Growth performance and adaptability of European sea bass (Dicentrarchus labrax) gut microbiota to alternative diets free of fish products. Microorganisms, in press. (*co-corresponding authors)
Chekli Y, Perron-Cane C, Dell’Arcipret D, Allemand JF, Li C, Ghigo JM, Gauthier A, Lebreton A, Desprat N*, Beloin C* (2020) Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST. Scientific Reports, Sep 25;10(1):15791. doi: 10.1038/s41598-020-72498-2 (*co-corresponding authors)
Béchon* N, Mihajlovic* J, Vendrell-Fernandez S, Chain F, Langella P, Beloin C, and Ghigo JM (2020) Capsular polysaccharides cross-regulation modulates Bacteroides thetaiotaomicron biofilm formation. mBio May/June 2020 Vol. 11 Issue 3, e00729-20
Thaïs Couasnon , Damien Alloyeau*, Bénédicte Ménez , François Guyot , Jean-Marc Ghigo and Alexandre Gélabert* (2020). In situ monitoring of exopolymer-dependent Mn mineralization on bacterial surfaces Science Advances. in press
Béchon N, Jiménez-Fernández A, Witwinoski J, Bierque E, Taib N, Cokelaer T, Ma L, Ghigo JM, Gribaldo S, Beloin C (2020) Autotransporters drive biofilm formation and auto-aggregation in the diderm Firmicute Veillonella parvula. Journal of Bacteriology, in press.