Biofilms are communities of microorganisms that interact with surfaces, and are known to display unique properties that differentiate them from free-floating, individual microorganisms. While biofilms are widespread and play many positive roles in all environments, they are also difficult to eradicate when adhered to surfaces in medical and industrial settings.
We use genetics, genomics, molecular biology, and various in vitro and in vivo biofilm models to better understand biofilm-associated functions used by commensal and pathogenic bacteria. We also attempt to translate our fundamental approaches into relevant anti-biofilm strategies in collaboration with clinicians and industrial partners.
Kyrie GRASEKAMP is now Dr Kyrie GRASEKAMP!
Bernal-Bayard J, Thiebaud J, Brossaud MJ, Beaussart A, Caillet C, Waldvogel Y, Travier L,Létoffé S, Fontaine T, Rokbi B, Talaga P, Beloin C., Mistretta N*, Duval JFL*, Ghigo JM*. (2023) Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties. Nature Communications. May 3;14(1):2553. doi: 10.1038/s41467-023-37925-8. .
Yankel Chekli, Rebecca J. Stevick, Etienne Kornobis, Valérie Briolat, Jean-Marc Ghigo and Christophe Beloin*. (2023). Escherichia coli aggregates mediated by native or synthetic adhesins exhibit both core and adhesin-specific transcriptional responses. Microbiology Spectrum, Apr 11;e0069023. doi: 10.1128/spectrum.00690-23.
Masaru Usui, Yutaka Yoshii, Stanislas Thiriet-Rupert Jean-Marc Ghigo and Christophe Beloin. (2023) Intermitent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance. Communications Biology Mar 16;6(1):275. doi: 10.1038/s42003-023-04601-y.
Znaidia M, de Sousa Angelo Y, Létoffé S, Staropoli I, Grzelak L, Ghigo JM, Schwartz O, Casartelli N. (2023) Bacteria promote HIV-1 replication in activated peripheral blood CD4+ T cells and reveal the localization of CD25 at the virological synapse. Microbiology Spectrum, Feb 28:e0431322. doi: 10.1128/spectrum.04313-22.