Biofilms are communities of microorganisms that interact with surfaces, and are known to display unique properties that differentiate them from free-floating, individual microorganisms. While biofilms are widespread and play many positive roles in all environments, they are also difficult to eradicate when adhered to surfaces in medical and industrial settings.We use genetics, genomics, molecular biology, and various in vitro and in vivo biofilm models to better understand biofilm-associated functions used by commensal and pathogenic bacteria. We also attempt to translate our fundamental approaches into relevant anti-biofilm strategies in collaboration with clinicians and industrial partners.
• López-Igual, R., Bernal-Bayard, J., Rodríguez-Patón, A., Ghigo, J.M., and Didier Mazel.(2019). Engineering synthetic toxin-intein weapons as specific antimicrobials Nature Biotechnology.April 15. https://doi.org/10.1038/s41587-019-0105-3
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• Usui M*, Yokoo H, Tamura Y, Nakajima C, Suzuki Y, Ghigo JM, and Beloin C*. (2019). Zinc acetate potentiates the action of tosufloxacin on Escherichia coli biofilm persisters. Antimicrobial Agents and Chemotherapy. Apr 1. pii: AAC.00069-19. doi: 10.1128/AAC.00069-19. (*co-corresponding authors)
• Mihajlovic ,J.; Béchon, N.; Ivanova, C.; Chain, F.; Almeida, A.; Langella, P.; Beloin, C. and J.-M. Ghigo. (2019). A putative type V pilus contributes to Bacteroides thetaiotaomicron biofilm formation capacity. Journal of Bacteriology. .Mar 4. pii: JB.00650-18. doi: 10.1128/JB.00650-18.