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About

Our work deals with some aspects of bacteria’s impressive capacities to acquire and exchange genes… which enable bacteria to evolve very fast and efficiently!

We study the mechanisms responsible of the bacterial genome variability, with a special interest for those involved in exogenous gene acquisition – the horizontal gene transfer. Our model system is the integron, a natural genetic engineering system involved in the development and dissemination of antibiotic resistance genes among Gram-negative species. We are characterizing the molecular mechanisms in these elements, as well as their evolution and phenotypic impact on host cell physiology.

We have recently moved to the study of the effects of subinhibitory concentrations of antibiotics, on the SOS response induction and beyond to their role as general stress inducers. We mostly use genetics and postgenomics approaches to tackle these questions.

We are also investigating the factors playing a role in the repair and maintenance of the two chromosomes of Vibrio cholerae. All Vibrio species have genome constituted of two circular chromosomes with distinct dynamic characteristics, and we aim at understanding both the selective benefit of this organization as well as the specific machinery in charge of their maintenance.

We recently developped a new antimicrobial technology based on the expression and delivery of specific toxin-intein modules which are only activated in the targeted pathogenic bacteria.

An illustration of our most recent article in Nature Biotechnology

 

Former Members

2000
2000
Name
Position
2015
2019
Anne-Marie Guérout
Retired scientist
2015
2019
Dean Rowe-Magnus
Post-doc
2015
2019
Latefa Biskri
PhD Student
2015
2019
Chiho Mashimo 
Post-doc
2015
2019
Clara Frumerie
Post-doc
2015
2019
Gaelle Demarre
PhD Student
2015
2019
Marie Bouvier
Undergraduate Student
2015
2019
Mohamed Zouine 
Post-doc
2015
2019
Johan Binesse
PhD Student
2015
2019
Ana Babic
Post-doc
2015
2019
Frédérique Le Roux
Permanent Researcher
2015
2019
Guillaume Cambray
Post-doc
2015
2019
Marie-Cécile Ploy
Post-doc
2015
2019
Fernando de la Cruz
Visiting Scientist
2015
2019
David Bikard
Head of Structure
2015
2019
Henning Sørum
Visiting Scientist
2015
2019
Naeem Iqbal
PhD Student
2015
2019
Michael Jason Bland
Post-doc
2015
2019
Christophe Thomas
Technician
2015
2019
Geneviève Garriss
Post-doc
2015
2019
Maria Vittoria Mazzuoli
PhD Student
2015
2019
Mounira Tiouajni
Post-doc
2015
2019
Anncharlott Berglar
PhD Student
2015
2019
Isabelle Dulieu
Administrative Staff
2015
2019
José Escudero
Post-doc
2015
2019
Alfonso Soler
Post-doc
2015
2019
Deshmukh Gopaul
Head of Structure
2015
2019
Aleksandra Nivina
PhD Student
2015
2019
Veronica Negro
PhD Student
2015
2019
Francisco de Lemos Martins
PhD Student
2015
2019
Rocio Lopez Igual
Post-doc
2015
2019
Xavier Eyer
Undergraduate Student
2015
2019
Sebastian Aguilar Pierle
Post-doc

Projects

Transversal Project

Fundings

Publications

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Contact

Phone: +33 (0)1 40 61 32 84 Email: mazel@pasteur.fr Administrative Assistant: Isabelle Hoffmann Email: isabelle.hoffmann@pasteur.fr Phone: +33 (0)1 45 68 88 10 Address 25-28, rue du Docteur Roux 75015 Paris France