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About

Our work deals with some aspects of bacteria’s impressive capacities to acquire and exchange genes… which enable bacteria to evolve very fast and efficiently!

We study the mechanisms responsible of the bacterial genome variability, with a special interest for those involved in exogenous gene acquisition – the horizontal gene transfer. Our model system is the integron, a natural genetic engineering system involved in the development and dissemination of antibiotic resistance genes among Gram-negative species. We are characterizing the molecular mechanisms in these elements, as well as their evolution and phenotypic impact on host cell physiology.

We have recently moved to the study of the effects of subinhibitory concentrations of antibiotics, on the SOS response induction and beyond to their role as general stress inducers. We mostly use genetics and postgenomics approaches to tackle these questions.

We are also investigating the factors playing a role in the repair and maintenance of the two chromosomes of Vibrio cholerae. All Vibrio species have genome constituted of two circular chromosomes with distinct dynamic characteristics, and we aim at understanding both the selective benefit of this organization as well as the specific machinery in charge of their maintenance.

We recently developped a new antimicrobial technology based on the expression and delivery of specific toxin-intein modules which are only activated in the targeted pathogenic bacteria.

An illustration of our most recent article in Nature Biotechnology

 

Former Members

2000
2000
Name
Position
1998
2013
Anne-Marie Guérout
Retired scientist
2015
2019
Dean Rowe-Magnus
Post-doc
2015
2019
Latefa Biskri
PhD Student
2015
2019
Chiho Mashimo 
Post-doc
2015
2019
Clara Frumerie
Post-doc
2015
2019
Gaelle Demarre
PhD Student
2015
2019
Marie Bouvier
Undergraduate Student
2015
2019
Mohamed Zouine 
Post-doc
2015
2019
Johan Binesse
PhD Student
2015
2019
Ana Babic
Post-doc
2015
2019
Frédérique Le Roux
Permanent Researcher
2015
2019
Guillaume Cambray
Post-doc
2015
2019
Marie-Cécile Ploy
Post-doc
2015
2019
Fernando de la Cruz
Visiting Scientist
2010
2011
David Bikard
Head of Structure
2000
2000
Henning Sørum
Visiting Scientist
2007
2011
Naeem Iqbal
PhD Student
2010
2014
Michael Jason Bland
PhD Student/Post-doc
2011
2016
Christophe Thomas
Technician
2013
2015
Geneviève Garriss
Post-doc
2016
2016
Maria Vittoria Mazzuoli
Undergraduate Student
2013
2015
Mounira Tiouajni
Post-doc
2012
2015
Anncharlott Berglar
PhD Student
2013
2016
Isabelle Dulieu
Administrative Staff
2011
2016
José Escudero
Post-doc
2011
2017
Alfonso Soler Bistué
Post-doc
2000
2017
Deshmukh Gopaul
Head of Structure
2012
2017
Aleksandra Nivina
PhD Student/Post-doc
2014
2018
Veronica Negro
PhD Student
2014
2018
Francisco de Lemos Martins
PhD Student
2014
2018
Rocio Lopez Igual
Post-doc
2017
2018
Xavier Eyer
Undergraduate Student
2014
2019
Sebastian Aguilar Pierlé
Post-doc
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Projects

Transversal Project

Fundings

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Contact

Phone: +33 (0)1 40 61 32 84 Email: mazel@pasteur.fr Administrative Assistant: Isabelle Hoffmann Email: isabelle.hoffmann@pasteur.fr Phone: +33 (0)1 45 68 88 10 Address 25-28, rue du Docteur Roux 75015 Paris France