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© Institut Pasteur/Antoinette Ryter
Salmonella spp. Bactéries à Gram négatif, aérobies ou anaérobies facultatifs à transmission orofécale. Les salmonelles majeures (sérotype typhi et sérotype paratyphi) sont responsables des fièvres typhoïde et paratyphoïde chez l'homme uniquement ; les salmonelles mineures (sérotype typhimurium et sérotype enteritidis) sont impliquées dans 30 à 60 % des gastroentérites et toxiinfections d'origine alimentaire. Image colorisée.

About

The Unit includes the National Reference Center (CNR) for Salmonella, Shigella/Escherichia coli and the NRC for  Vibrio and Cholera, and a WHO Collaborating Center.  Our research interests are strongly linked to public health and reference activities for the enteric bacterial pathogens monitored by the Unit. We work on three partly overlapping themes: (i) identification and dynamics of bacterial populations resistant to antibiotics (ii) development of new bacterial typing and diagnostic tools, (iii) population structures and the evolution of genetically monomorphic pathogenic agents, with a special focus on emergent, epidemic and antimicrobial-resistant bacterial populations.

 

 

Members

Francois-Xavier Weill
Head of Structure
Head
Marie-Laure Quilici
Director of National Reference Center
Sophie Lefevre
Deputy Director of National Reference Center
Annick Robert-Pillot
Deputy Director of National Reference Center
Carole Gaston
Administrative Staff
Laétitia Fabre
Research Engineer
Elisabeth Njamkepo Nguemkam
Research Engineer
Marie Accou-Demartin
Technician
Chantal Belhassen
Technician
Isabelle Carle
Technician
Brigitte Chavinier-Jove
Technician
Véronique Guibert
Technician
Sylvie Issenhuth-Jeanjean
Technician
Monique Lejay-Collin
Technician
Jean Rauzier
Technician
Magali Ravel
Technician
Corinne Ruckly
Technician
Estelle Serre
Technician
Florence Juglas
Administrative Staff
María Pardos de la Gándara
Deputy Director of National Reference Center
Slim El-Khiari
Research Engineer
Hawa Yaffa
Technician

Projects

project
Ongoing
5 Members

Evolutionary history of the classical biotype of Vibrio cholerae O1

Francois-Xavier Weill (PI)

The classical biotype of Vibrio cholerae O1 was responsible for the first six cholera pandemics, but is relatively unknown, with only 20 genome sequences (50% of which come from the same geographic area) for […]
project
Completed
6 Members

Genomic insights into the 2016-2017 cholera epidemic in Yemen

Francois-Xavier Weill (PI)

Cholera is thought by many to be a disease of the Victorian era. However, Yemen has recently experienced one of the largest ever cholera epidemics. The first cases were declared in September 2016, and […]
project
Completed
3 Members

Historical antibiotic-resistant populations of S. enterica serotype Typhimurium

Francois-Xavier Weill (PI)

Little is known about the emergence and spread of the first antibiotic-resistant populations. It is believed, for example, that the very common penicillinase gene, blaTEM-1, discovered for the first time in E. coli in Greece […]
project
Ongoing
8 Members

Oxford Nanopore sequencing for detection and surveillance of pathogens

Sylvain Brisse (PI)

This project intends to share expertise, developments, equipement and bioinformatics tools to apply Oxford Nanopore Technology sequencing to the detection, diagnostic and characterization of pathogens of public health importance. It corresponds to a collaboration […]
project
Completed
4 Members

Phylodynamics of Vibrio cholerae O1 in Africa (1970-2014)

Francois-Xavier Weill (PI)

In 1970, ten years after the beginning of the 7th pandemic (Indonesia, 1961), cholera hit Africa, where it has remained entrenched. Three decades later, the reported incidence of indigenous cholera in sub-Saharan Africa was […]
project
Completed
16 Members

Phylogenomics of Shiga’s epidemic dysentery bacillus (Shigella dysenteriae type 1)

Francois-Xavier Weill (PI)

The agent of epidemic dysentery, the bacterium Shigella dysenteriae type 1, was isolated in Japan in 1897 by Dr Kyoshi Shiga during a massive epidemic of bloody diarrhea that caused 20,000 deaths over a […]
project
Ongoing
19 Members

Escherichia coli-Shigella-Salmonella

Francois-Xavier Weill (PI)

The Unit includes two National Reference Centers (CNR) and a WHO Collaborating Center. Our interests are the population dynamics of bacterial enteric pathogens such Salmonella, Shigella/Escherichia coli and Vibrio, with a special focus on […]

Transversal Project

Fighting Antibiotic Resistance

Antibiotics are highly efficient drugs to kill pathogenic bacteria with low side effects. For more than 70 years, the massive use of these miracle drugs has saved millions of human and animal lives. Unfortunately […]

Institut Carnot Pasteur MS

The Carnot Label Carnot label is granted to public research structures, showing high level R&D competencies dedicated to fostering innovation with industrial partners. The Carnot Institutes (IC) are funded to conduct upstream research capable […]

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Contact

Enteric Bacterial Pathogens Unit 28 rue du Docteur Roux -75724 PARIS Cedex 15-France. Tel : + 33 (1) 45 68 83 45 (secretary: + 33 (1) 45 68 82 21) Fax : + 33 (1) 45 68 88 37 E-mail : francois-xavier.weill@pasteur.fr