The Unit includes the National Reference Center (CNR) for Salmonella, Shigella/Escherichia coli and the NRC for Vibrio and Cholera, and a WHO Collaborating Center. Our research interests are strongly linked to public health and reference activities for the enteric bacterial pathogens monitored by the Unit. We work on three partly overlapping themes: (i) identification and dynamics of bacterial populations resistant to antibiotics (ii) development of new bacterial typing and diagnostic tools, (iii) population structures and the evolution of genetically monomorphic pathogenic agents, with a special focus on emergent, epidemic and antimicrobial-resistant bacterial populations.
The SARA project: Surveillance of Antibiotic Resistance in Africa, an integrative project of the Pasteur Network
Antibiotic resistance is one of the most serious threats to global health. The consequences for human health are particularly severe in low-resource countries, and in Africa in particular. The SARA project is funded by […]
Evolutionary history of the classical biotype of Vibrio cholerae O1
The classical biotype of Vibrio cholerae O1 was responsible for the first six cholera pandemics, but is relatively unknown, with only 20 genome sequences (50% of which come from the same geographic area) for […]
Genomic insights into the 2016-2017 cholera epidemic in Yemen
Cholera is thought by many to be a disease of the Victorian era. However, Yemen has recently experienced one of the largest ever cholera epidemics. The first cases were declared in September 2016, and […]
Historical antibiotic-resistant populations of S. enterica serotype Typhimurium
Little is known about the emergence and spread of the first antibiotic-resistant populations. It is believed, for example, that the very common penicillinase gene, blaTEM-1, discovered for the first time in E. coli in Greece […]
Oxford Nanopore sequencing for detection and surveillance of pathogens
This project intends to share expertise, developments, equipement and bioinformatics tools to apply Oxford Nanopore Technology sequencing to the detection, diagnostic and characterization of pathogens of public health importance. It corresponds to a collaboration […]
Phylodynamics of Vibrio cholerae O1 in Africa (1970-2014)
In 1970, ten years after the beginning of the 7th pandemic (Indonesia, 1961), cholera hit Africa, where it has remained entrenched. Three decades later, the reported incidence of indigenous cholera in sub-Saharan Africa was […]
Phylogenomics of Shiga’s epidemic dysentery bacillus (Shigella dysenteriae type 1)
The agent of epidemic dysentery, the bacterium Shigella dysenteriae type 1, was isolated in Japan in 1897 by Dr Kyoshi Shiga during a massive epidemic of bloody diarrhea that caused 20,000 deaths over a […]
The Unit includes two National Reference Centers (CNR) and a WHO Collaborating Center. Our interests are the population dynamics of bacterial enteric pathogens such Salmonella, Shigella/Escherichia coli and Vibrio, with a special focus on […]
Emerging Infectious Diseases
Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]
Antibiotics are highly efficient drugs to kill pathogenic bacteria with low side effects. For more than 70 years, the massive use of these miracle drugs has saved millions of human and animal lives. Unfortunately […]
The institut Carnot Pasteur MS
Carnot, label of excellence Founded in 2006, the Carnot Label, granted by the French government, was designed to develop partnership-based research, meaning research conducted by public laboratories in partnership with socio-economic players, primarily industry […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
2021Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa., Nat Microbiol 2021 Mar; 6(3): 327-338.
2021Seventh Pandemic Vibrio cholerae O1 Sublineages, Central African Republic., Emerg Infect Dis 2021 Jan; 27(1): 262-266.
2020Endocannabinoids Attenuate the Virulence of Certain Enteropathogenic Bacteria., Trends Microbiol 2020 Dec; (): .
2020The seventh pandemic of cholera in Europe revisited by microbial genomics., Nat Commun 2020 10; 11(1): 5347.
2020Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors., Gut Microbes 2020 09; 11(5): 1287-1299.
2020Highly Resistant Cholera Outbreak Strain in Zimbabwe., N. Engl. J. Med. 2020 08; 383(7): 687-689.
2020Antimicrobial Resistance in Salmonella enterica Serovar Paratyphi B Variant Java in Poultry from Europe and Latin America., Emerging Infect. Dis. 2020 Jun; 26(6): 1164-1173.
2020The EnteroBase user’s guide, with case studies on Salmonella transmissions, Yersinia pestis phylogeny, and Escherichia core genomic diversity., Genome Res. 2020 01; 30(1): 138-152.
2019Serotype distribution and antimicrobial resistance of human Salmonella enterica in Bangui, Central African Republic, from 2004 to 2013., PLoS Negl Trop Dis 2019 12; 13(12): e0007917.
2019Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei., Nat Commun 2019 10; 10(1): 4828.
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Enteric Bacterial Pathogens Unit 28 rue du Docteur Roux -75724 PARIS Cedex 15-France. Tel : + 33 (1) 45 68 83 45 (secretary: + 33 (1) 45 68 82 21) Fax : + 33 (1) 45 68 88 37 E-mail : email@example.com