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How bacteria defend themselves against their viruses ?Facing the abundance and diversity of their viruses, bacteria and archaea have developed multiple lines of defense that can be referred to as “prokaryotic anti-viral systems“. Our research focuses on these anti-phage systems.
We are trying to understand evolutionary patterns and molecular mechanisms of these systems but also how to use them for medical applications. We work at several scales: from computational genomic analysis on thousands of prokaryotic genomes to experimental molecular genetics and diverse microbiology tools.We are currently working on the ecology and evolution of anti-phage systems, their conservation with eukaryotic immune systems and how we can harness them for the fight against pathogens.
You can learn more about our field of research through the podcast Micrboes and Us by FEMS where we discussed anti viral defense in bacteria (Episode 12).