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© Laurent Debarbieux
Bactériophages sur la bactérie Escherichia coli 0104:H4 souche 55989.

About

Since their discovery in the early twentieth century, researchers have exploited bacteriophages (viruses that infect only bacteria). First, bacteriophages have been used to fight against human bacterial infections, they they were used as models for studying basic cellular mechanisms (replication, transcription, regulation …) and more recently they have become valuable tools in biotechnology. The extensive study of bacteriophages has led to the birth and development of molecular biology, which has provided many and is still providing tools, such as the genome editing Cas9 protein isolated from CRSIPRs-Cas systems.

cycle-infectieux-fr-bf

Surprisingly, bacteriophages have been poorly studied in the environment where they are ubiquitous (at sea, on land and even in the air). They are also found in many human sites (gut, mouth, skin …). Their presence is directly linked to the presence of bacteria, but their role is still obscure. We can distinguish broadly two types of bacteriophages named temperate and virulent. Our main objective focuses on studying the interactions between virulent bacteriophages and bacteria in animals.

First, we seek to understand how these interactions evolve within a complex microbial ecosystem, the digestive tract of mammals. Many recent studies have highlighted the involvment of the intestinal microbiota on several human diseases and disorders pointing toward the role of specific bacteria. But despite their abundance in the intestines the role of bacteriophages within the microbiota remains elusive.

Second, we study the parameters required to develop the therapeutic use of bacteriophage (phage therapy). This medical treatment, originally developed in France a century ago, is now back on the forefront of the solutions to fight against infections caused by antibiotics resistant bacteria. Our studies focus specifically on the treatment of pulmonary infections.

The IBBA team (October 2019)

 

To watch a video introducing phage therapy, click here

Our team is part of the network Phages.fr and of the international society for viruses of microorganims (www.isvm.org).

L. Debarbieux is a co-founder of the association P.H.A.G.E. (www.p-h-a-g-e.org).

Former Members

2000
2000
Name
Position
2015
2019
Marta Mansos Lourenço
PhD Student
2014
2018
Dwayne Roach
Post-doc
2014
2018
Luisa De Sordi
Post-doc
2014
2015
Camille Caplain
Research Engineer
2014
2015
Helena Shomar
Research Engineer
2013
2017
Anne Chevallereau
PhD Student
2012
2016
Nicolas Dufour
PhD Student
2011
2013
Marine Henry
Post-doc
2011
2014
Mathieu Galtier
PhD student
2009
2012
Emilie Saussereau
PhD Student
2008
2010
Eric Morello
Post-doc
2008
2011
Damien Maura
PhD Student
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Phone: Email: Address Fernbach Building 25-28 Rue du Docteur Roux 75015, Paris France