Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Bruno Dupuy, Claire Morvan, Institut Pasteur
Cellules végétative et spores de Clostridioides difficile / Vegative cells and spores of Clostridioides difficile

About

In Europe, the Gram-positive spore-forming anaerobic bacterium Clostridium difficile  is the leading cause of intestinal nosocomial post-antibiotic infections in adults. The C. difficile infections (CDI) generally occur in patients with compromised gut microbiota. C. difficile is responsible for 15-25% of cases of antibiotic-associated-diarrhoea and for almost all pseudomembranous colitis cases. CDI is a multi-step process that includes i) oral infection by environmental spores of toxigenic C. difficile strains or caught off hospital staff, ii) spore germination in dysbiotic intestinal lumen, iii) gut colonization by C. difficile vegetative cells (VC) and iv) production of toxins responsible for the symptoms followed by the dissemination of C. difficile spores. The virulence of C. difficile is primarily due to the production of two cytolytic toxins: TcdA and TcdB, which exert deleterious effects on epithelial cells. However many virulence factors seem to be involved during the gut colonization and the process of CDI. Therefore, the aims of our research were to decipher the key steps of the C. difficile pathogenesis and particularly the intestinal colonization, which is an essential prerequisite before toxin production. This include i) the adaptive strategies used by C. difficile in response to stresses encountered during infection including mechanisms of resistance to oxidative/nitrosative stress and biofilm formation; ii) the complex regulatory network of C. difficile sporulation and the relationships that occur between spores and colonic cells during colonization, iii)  the mechanisms of the regulation of toxin production in relation to cellular metabolic pathways and of their secretion and  vi) the impact of prophages in the genetic variability of C. difficile strains.

 

Courses

Workshop: Bacterial RNAseq

We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […]

2016-06-06 09:00:00 2016-06-10 17:00:00 Europe/Paris Workshop: Bacterial RNAseq We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […] 28 Rue du Docteur Roux, Paris, France

Projects

Transversal Project

Software

Fundings

Partners

Publications

Download

Contact

Phone: +33 140613175 Email: bdupuy@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France