The Ecology and Evolution of Antibiotic Resistance (EERA) Unit aims at characterizing factors contributing to the emergence and the dissemination of antibiotic resistance clones in the hospital and in the community. Our research projects focus on Enterobacteriaceae resistant to carbapenems and/or expressing extended spectrum b-lactamases. These isolates represent today one of the most urgent public health threats because of their dramatic increase throughout the world. To address this issue, we are analyzing the evolutionary changes leading to the successful dissemination of specific clones, and the interaction of antibiotic resistant strains with the gut microbiota. We are also searching for the intrinsic factors of these clones contributing to resistance, increased fitness and to a greater capacity to disseminate in the human host and the in the environment. We are combining in silico studies based on comparative genomics, epidemiology, phylogenomics and mathematical modeling with functional studies of bacterial physiology and regulation. The Unit is located at the Institut Pasteur and at the Bicêtre Hospital, and is a joint structure between the Institut Pasteur, the Assistance Public Hôpitaux de Paris (APHP) and the University Paris Sud. Establishing a link between research and clinical cases is a key focus of our research.
Whole genome sequencing and artificial intelligence to characterise and diagnose antibiotic resistance and capacity to escape treatment: Seq2Diag
Project in collaborations with the following partners; – InBio Unit, Inria (Grégory Batt) -CNRS, Laboratoire de Recherche en Informatique, Université Paris-Saclay (Flora Jay) -INSERM, Délégation régionale Paris 11, U1184 RESIST Team (Thierry Naas) -CNRS, […]
High-throughput identification of antibiotic resistance progenitors across interconnected settings: PRE-EMPT
Project with the following partners: -INSERM UMR1092, Université de Limoges (Marie-Cécile Ploy) -Anses, Unité Antibiorésistance et virulence bactériennes (Jean-Yves Madec) -INRAE, UMR-1282, Université de Tours (Sébastien Leclercq)
MedVetKlebs: Klebsiella pneumoniae from ecology to source attribution and transmission control
Klebsiella pneumoniae (hereafter, K. pneumoniae) is a major cause of hospital-acquired infections such as urinary infections, pneumonia, bloodstream infections, infections in newborns and in intensive-care unit patients. Some hypervirulent strains also cause community infections […]
Dynamics of Gut Microbiota
Acquisition of antibiotic resistant bacteria and development of the gut microbiome in neonates in low-income countries. Antibiotic resistance represents a major health issue worldwide. The situation is particularly acute in low-income countries (LIC), due […]
Emerging Infectious Diseases
Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]
Fighting Antibiotic Resistance
Antibiotics are highly efficient drugs to kill pathogenic bacteria with low side effects. For more than 70 years, the massive use of these miracle drugs has saved millions of human and animal lives. Unfortunately […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
2021The CovR regulatory network drives the evolution of Group B Streptococcus virulence., PLoS Genet 2021 Sep; 17(9): e1009761.
2021Evolution of VIM-1-Producing Klebsiella pneumoniae Isolates from a Hospital Outbreak Reveals the Genetic Bases of the Loss of the Urease-Positive Identification Character., mSystems 2021 Jun; (): e0024421.
2021Gnotobiotic rainbow trout (Oncorhynchus mykiss) model reveals endogenous bacteria that protect against Flavobacterium columnare infection., PLoS Pathog 2021 01; 17(1): e1009302.
2020Diversity of mucoid to non-mucoid switch among carbapenemase-producing Klebsiella pneumoniae., BMC Microbiol 2020 Oct; 20(1): 325.
2020Concomitant carriage of KPC-producing and non-KPC-producing Klebsiella pneumoniae ST512 within a single patient., J Antimicrob Chemother 2020 Aug; 75(8): 2087-2092.
2020A single Proteus mirabilis lineage from human and animal sources: a hidden reservoir of OXA-23 or OXA-58 carbapenemases in Enterobacterales., Sci Rep 2020 06; 10(1): 9160.
2020Emergence of New Non-Clonal Group 258 High-Risk Clones among Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Isolates, France., Emerg Infect Dis 2020 06; 26(6): 1212-1220.
2020Antibiotic resistance: turning evolutionary principles into clinical reality., FEMS Microbiol Rev 2020 03; 44(2): 171-188.
2019SME-4-producing Serratia marcescens from Argentina belonging to clade 2 of the S. marcescens phylogeny., J Antimicrob Chemother 2019 07; 74(7): 1836-1841.
2019Conserved and specific features of Streptococcus pyogenes and Streptococcus agalactiae transcriptional landscapes., BMC Genomics 2019 Mar; 20(1): 236.
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