The Ecology and Evolution of Antibiotic Resistance (EERA) Unit aims at characterizing factors contributing to the emergence and the dissemination of antibiotic resistance clones in the hospital and in the community. Our research projects focus on Enterobacteriaceae resistant to carbapenems and/or expressing extended spectrum b-lactamases. These isolates represent today one of the most urgent public health threats because of their dramatic increase throughout the world. To address this issue, we are analyzing the evolutionary changes leading to the successful dissemination of specific clones, and the interaction of antibiotic resistant strains with the gut microbiota. We are also searching for the intrinsic factors of these clones contributing to resistance, increased fitness and to a greater capacity to disseminate in the human host and the in the environment. We are combining in silico studies based on comparative genomics, epidemiology, phylogenomics and mathematical modeling with functional studies of bacterial physiology and regulation. The Unit is located at the Institut Pasteur and at the Bicêtre Hospital, and is a joint structure between the Institut Pasteur, the Assistance Public Hôpitaux de Paris (APHP) and the University Paris Sud. Establishing a link between research and clinical cases is a key focus of our research.
Save the date: under the umbrella of the LabEx IBEID, we are organizing an international conference entitled “Challenges and new concepts in antibiotics research” at the Institut Pasteur in Paris on March 19-21 2018. Please visit the website of the conference for further information: http://www.amr-2018.org/