© Research

Integrated Mycobacterial Pathogenomics


The research undertaken in our unit is centered on genomics and pathogenicity of mycobacteria, which we try to integrate into a common research program to uncover novel features of mycobacterial pathogens in relation with mycobacterial  evolution and the interaction of pathogenic mycobacteria with their hosts.

While most mycobacteria are harmless saprophytes, a few species have very efficiently adapted to a pathogenic lifestyle and constitute some of most important human pathogens. There are Mycobacterium tuberculosis, the causative agent of human tuberculosis, Mycobacterium leprae , the cause of leprosy and the emerging pathogen Mycobacterium ulcerans, which causes Buruli ulcer, a most serious skin disease mainly prevalent in West Africa.

Our research in the Unit is  focused on mycobacterial  research on these pathogenic  species, with main focus on mycobacterial type VII / ESX secretion systems, the patho-evolution of  the Mycobacterium tuberculosis complex – starting from a pool of Mycobacteriium canettii-like generic mycobacteria, as well as on selected aspects of mycobacterial pathogenicity, anti-mycobacterial immunity and anti-tuberculosis vaccine development.





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Prof. Roland Brosch

Phone: +33-1-45688446
Email: roland.brosch@pasteur.fr

25-28 Rue du Docteur Roux
75724, Paris, Cedex 15