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© Sandrine Etienne-Manneville
Photo prise à l'avant (dans la protrusion) d'astrocytes primaires de rat en migration. Marquage par immunofluorescence montrant en rouge, p150 Glued, une protéine associée aux extrémités 'plus' des microtubules et en vert la tubuline des microtubules. La photographie montre l'accumulation de p150 Glued à l'avant des cellules en migration, où la protéine pourrait participer à l'ancrage des microtubules à la membrane plasmique. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaires.

About

 

Nos intérêts de recherche se concentrent principalement sur l’étude des mécanismes moléculaires qui sous-tendent les interactions protéine-protéine et protéine-membrane, en utilisant une combinaison d’approches de génétique moléculaire, biochimique, biophysique et d’imagerie en direct.

institutpasteur_28619.jpgL’un de nos principaux systèmes modèles est une toxine bactérienne, l’adénylate cyclase (CyaA) produite par Bordetella pertussis , l’agent causal de la coqueluche. Les connaissances de base sur les mécanismes d’entrée de la toxine dans les cellules cibles eucaryotes et son interaction avec les effecteurs cellulaires sont exploitées pour diverses applications en vaccinologie et biotechnologie.

Former Members

2000
2000
Name
Position
2019
2020
Andrea Ori
Undergraduate Student
2018
2020
Jenny-Lee Thomassin
Post-doc
2017
2019
Alexis Voegele
PhD Student
2019
2019
Federica Mancinelli
Undergraduate Student
2019
2019
Flora Sangouard
Undergraduate Student
2019
2019
Zayed Bousraf
Undergraduate Student
2019
2019
Gabrielle Dejean de la Batie
Undergraduate Student
2015
2018
Alexander Belyy
PhD Student
2017
2018
Hazel Silistre
Post-doc
2014
2018
Areli Luna-Rico
PhD Student
2017
2018
Samantha Avila
Undergraduate Student
Mélanie Foulon
Graduate Student
2014
2017
Darragh O’Brien
Post-doc
2017
2018
Julia Tavares de Castro
Graduate Student
2017
2018
Mélanie Huet
Undergraduate Student
2016
2016
Louis-Antoine Barel
Graduate Student
2013
2016
Sara Elisabetta Cannella
PhD Student
2012
2016
Emilie Gauliard
PhD Student
Scot Ouellette
Post-Doc
Johanna Karst
Post-doc
2008
2013
Ana Cristina Sotomayor Pérez
PhD Student
2013
2015
Sylvia Seokhee Yong
Graduate Student
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Phone: +33 (1)45 68 84 00 (secretary: + 33 (1) 45 68 84 14) Email: daniel.ladant@pasteur.fr Biochemistry of Macromolecular Interactions – CNRS 3528 28 Rue du Docteur Roux 75015, Paris France