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© Sandrine Etienne-Manneville
Photo prise à l'avant (dans la protrusion) d'astrocytes primaires de rat en migration. Marquage par immunofluorescence montrant en rouge, p150 Glued, une protéine associée aux extrémités 'plus' des microtubules et en vert la tubuline des microtubules. La photographie montre l'accumulation de p150 Glued à l'avant des cellules en migration, où la protéine pourrait participer à l'ancrage des microtubules à la membrane plasmique. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaires.

About

 

Our research interests are mainly focused on the study of the molecular mechanisms that underlie protein-protein and protein-membrane interactions, by using a combination of molecular genetics, biochemical, biophysical and live-imaging approaches.

institutpasteur_28619.jpgOne of our primary model system is a bacterial toxin, the adenylate cyclase (CyaA) produced by Bordetella pertussis, the causative agent of whooping cough. Basic knowledge on the mechanisms of toxin entry into eukaryotic target cells and its interaction with cellular effectors are exploited for various applications in vaccinology and biotechnology.

 

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