About

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system.

The Milieu Intérieur Project

While the immune system is highly complex and responses are known to vary across individuals and populations, medical practices and public health policies remain based on a single model of patient care and drug development. The Milieu Intérieur project was initiated specifically to address this discrepancy. The primary objective of our work is to establish the boundaries of a “healthy” immune response and define the determinants of immune response variation, integrating the relationship among genetics, epigenetics and the environment. The specific aims of the Milieu Intérieur project are to: (i) define the naturally-occurring variability of human immune response, (ii) assess how this variation is genetically, epigenetically or environmentally controlled, (iii) understand how this genetic/phenotypic variation may account for differences in susceptibility to infection, therapeutic treatment or vaccine response, and (iv) ascertain the variation and role of the microbiota in regulating immune programs. MI Design

The Milieu Intérieur dataset. Click to enlarge.

Milieu Intérieur 2 (MI2) – The next phase

For the next 5-year period, we will build on the existing solid foundations to extend our understanding of how genetics, microbiome and environmental factors determine immune response variability. For this we will

  • Explore the genetic, microbiome and environmental determinants of immune response variation in the adult population
  • Define the drivers of immune response variation in extreme ages and other geographic regions
  • Apply a systems immunology approaches to human disease to ensure that relevant clinical discoveries will be translated into improved patient care

The Milieu Intérieur project is supported by the French National Ministry of Research. This program is part of a larger French government’s Invest in the Future economic stimulus plan called Investissement d’Avenir  – Laboratoire d’Excellence (LabEx).

Past events

Milieu Intérieur Satellite Symposium: Human cohort studies for a better understanding of immunity

Address: The Convention Centre Dublin, North Wall Quay, North Dock, Dublin 1, Irlande
2024-09-01 2024-09-01 Europe/Paris Darragh Duffy Darragh Duffy leads the Translational Immunology unit at the Institut Pasteur, Paris and is co-coordinator of the LabEx Milieu Interieur project. The overall goal of his research is to better understand the fundamental mechanisms […] The Convention Centre Dublin, North Wall Quay, North Dock, Dublin 1, Irlande

Immunological data analysis and integration Symposium & Workshop

Building: Jaques MONOD – Room: Amphiteatre Agnes ULLMAN – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2024-04-24 2024-04-26 Europe/Paris Group : Milieu Intérieur The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […] Institut Pasteur, Rue du Docteur Roux, Paris, France

2nd Milieu Intérieur Population and Systems Immunology Symposium – Darragh Duffy, Lluis Quintana-Murci

Building: Institut Pasteur – Room: Amphitheatre François Jacob – Address: Rue du Docteur Roux, Paris, France
2022-10-18 2022-10-18 Europe/Paris Genomes and Genetics The teams of the department Genomes & Genetics are interested by questions related to gene regulation and evolutionary dynamics, including: Replication fidelity. Quality control of gene expression. Genetic diversity of populations and its impact […] Rue du Docteur Roux, Paris, France

International Symposium – Genetic Admixture: Inference and Evolutionary Consequences – Monday 30th and Tuesday 31st May 2022

Room: Amphitheatre Maurice Halbwachs – Address: Collège de France, Place Marcelin Berthelot, Paris, France
2022-05-30 2022-05-31 Europe/Paris Etienne Patin I have concentrated my past and current work on three main research topics: (i) the genetic history of human populations with distinct modes of subsistence, (ii) the role of admixture in genetic adaptation, and […] Collège de France, Place Marcelin Berthelot, Paris, France

The ageing immune system: implications for disease susceptibility – Nollaig Bourke

Address: 28 Rue du Docteur Roux, Paris, France
2021-03-08 2021-03-08 Europe/Paris Clementine Schilte I am the head of Digital Education at Institut Pasteur : https://www.pasteur.fr/fr/e-learning-mooc I’m passionate about biomedical research. I enjoy participating in the creation of new knowledge, imagining its applications, and facilitating the transmission of […] 28 Rue du Docteur Roux, Paris, France

Immunogenomics of Disease: Accelerating to Patient Benefit 2021 – Lluis Quintana-Murci

Address: 25 Rue du Docteur Roux, Paris, France
2021-02-10 2021-02-12 Europe/Paris LabEx Milieu Intérieur The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […] 25 Rue du Docteur Roux, Paris, France

Milieu Intérieur Annual Meeting 2020

Building: Virtual attendance – Room: Online Meeting – Address: 25 Rue du Docteur Roux, Paris, France
2020-12-01 2020-12-01 Europe/Paris Darragh Duffy Darragh Duffy leads the Translational Immunology unit at the Institut Pasteur, Paris and is co-coordinator of the LabEx Milieu Interieur project. The overall goal of his research is to better understand the fundamental mechanisms […] 25 Rue du Docteur Roux, Paris, France

FOCIS 2020

Address: 25 Rue du Dr Roux, Paris, France
2020-10-28 2020-10-31 Europe/Paris LabEx Milieu Intérieur The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […] 25 Rue du Dr Roux, Paris, France

PhD thesis defence Celine Posseme “Study of natural immune variability to dissect cytokine response pathways”

Building: Metchnikoff – Room: Salle Jules Bordet – Address: 25 Rue du Docteur Roux, Paris, France
2020-09-17 2020-09-17 Europe/Paris Darragh Duffy Darragh Duffy leads the Translational Immunology unit at the Institut Pasteur, Paris and is co-coordinator of the LabEx Milieu Interieur project. The overall goal of his research is to better understand the fundamental mechanisms […] 25 Rue du Docteur Roux, Paris, France
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Teams

Collaborations

To see see all the collaborations that the Milieu Intérieur Consortium has started please visit our website

Data visualization

Visualize the data from our Immunity paper “Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli” Duffy et al Slide4

Partners

Featured Projects

Featured Publications

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