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© Matteo Bonazzi, Edith Gouin
Observation en immunofluorescence d'une cellule infectée par Listeria monocytogenes. En bleu: marquage des protéines de surface de Listeria qui permet de visualiser les bactéries. En rouge et vert: marquage de l'actine, une protéine qui forme le cytosquelette des cellules. Les Listeria utilisent l'actine cellulaire pour former des "comêtes" et se déplacer à l'intérieur des cellules qu'elles infectent. Cell infected by Listeria monocytogenes. The surface proteins (in blue) of Listeria enable us to view the bacteria. Actin, a constituent protein of cells, is shown in red and green.

About

Antibodies in Therapy & Pathology (INSERM UMR 1222): focus on Allergy, Autoimmunity and Immunotherapy

Antibodies are key effectors of the immune system. They are responsible for disease induction (autoimmunity, allergy) and can be protecting from or facilitating infections and tumors. Antibodies are secreted by terminally differentiated B cells, plasmablasts and plasma cells. Antibodies do not generally exert by themselves, however, biological functions: these are mainly mediated by antibody receptors (FcRs) and complement component C1q.

Aims:

1) Decipher the role of human antibodies, human antibody receptors (FcRs) and the cells expressing them (neutrophils, monocytes/macrophages, platelets, mast cells, basophils), and human complement during therapy and in the induction of pathologies (severe allergy & autoimmunity), using primarily mouse models “humanized” for these components.

2) Establish high-throughput plasma cell screening, analysis and/or sorting using droplet microfluidics technologies to understand the antibody response, repertoire and affinities, and demonstrate the pathogenic nature of antibodies in specific diseases .

3) Develop clinical studies (AUTOIMMUNI-B; NASA; WaspPenIP; ENDOPHEN) to understand how antibodies and their effector functions induce/regulate autoimmune and allergic diseases

4) Develop novel antibody-based therapeutics

Altogether, our research integrating fundamental, clinical and industry-driven approaches, aims at elucidating the role of antibodies, their receptors and the cells expressing them in major disease and therapy models and, hopefully, propose novel therapeutic solutions in antibody-based therapies.

Members

Former Members

2000
2000
Name
Position
2015
2019
Marcello Albanesi
2015
2019
Florence Abdallah
Undergraduate Student
2015
2019
Lydia Madjene
Post-doc
2015
2019
Héloïse Beutier
PhD Student
2015
2019
Priscila Pini Zenatti
Post-doc
2015
2019
Caitlin Gillis
PhD Student
2015
2019
Biliana Todorova
Post-doc
2015
2019
Laure Delage
Graduate Student
2015
2019
Guillaume Mottet
Post-doc
2015
2019
Carlos Castrillon
PhD Student
2015
2019
Bianca Balbino
PhD Student
2015
2019
Ehsan Sarreshteh
Graduate Student
2015
2019
Kasia Kready
Graduate Student
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CONFERENCE ORGANIZATION

Jan 30, 2022- Feb 03, 2022 Antibodies as Drugs – Keystone Symposia ( Keystone Resort, Keystone, Colorado, USA) Organizers: Pierre Bruhns, Patrick C. Wilson, Esther Breij and David P. Humphreys  Executive Summary: Therapeutic antibodies continue to largely populate the list of top biologic drugs. They revolutionize the treatment of pathologies falling into major disease areas, which include cancer, chronic inflammatory diseases, allergy and infectious diseases. As more antibodies are being tested to treat an expanding number of pathologies, there has also been a concomitant increase in the frequency of resistance and escape mechanisms.  Thus, researchers are exploring alternative concepts to prevent unresponsiveness or treat resistant patients. Therefore, not only are new methodological and technological advances being developed, paradigm-shifting concepts are being developed in order to face these challenges. This conference in the Keystone Symposia series on Antibodies as Drugs aims to present the state-of-the-art in antibody therapeutics, repertoires and deep learning, bispecific antibodies and engineering. This conference will provide a forum for extensive interactions between investigators from both industry and academia. Goals of this conference include discussion of recent breakthroughs in identifying therapeutics from patients, understanding vaccination and mode of delivery, modalities for half-life extensions and involvement of complement in antibody mode of action. It is anticipated that research in the field will showcase the rise of bispecific antibodies and highlight the technologies to develop them, improve their functionalities, and boost clinical efficacies, particularly in immune-oncology.

Contact

Phone: 01 45 68 82 41 Email: daniele.sinnaya@pasteur.fr Address: Unit of Antibodies in Therapy and Pathology, Institut Pasteur, 25 Rue du Docteur Roux 75015, Paris, France.