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© Matteo Bonazzi, Edith Gouin
Observation en immunofluorescence d'une cellule infectée par Listeria monocytogenes. En bleu: marquage des protéines de surface de Listeria qui permet de visualiser les bactéries. En rouge et vert: marquage de l'actine, une protéine qui forme le cytosquelette des cellules. Les Listeria utilisent l'actine cellulaire pour former des "comêtes" et se déplacer à l'intérieur des cellules qu'elles infectent. Cell infected by Listeria monocytogenes. The surface proteins (in blue) of Listeria enable us to view the bacteria. Actin, a constituent protein of cells, is shown in red and green.
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Antibodies in Therapy & Pathology (INSERM UMR 1222): focus on Allergy, Autoimmunity and Immunotherapy

Antibodies are key effectors of the immune system. They are responsible for disease induction (autoimmunity, allergy) and can be protecting from or facilitating infections and tumors. Antibodies are secreted by terminally differentiated B cells, plasmablasts and plasma cells. Antibodies do not generally exert by themselves, however, biological functions: these are mainly mediated by antibody receptors (FcRs) and complement component C1q.

Aims:

1) Decipher the role of human antibodies, human antibody receptors (FcRs) and the cells expressing them (neutrophils, monocytes/macrophages, platelets, mast cells, basophils), and human complement during therapy and in the induction of pathologies (severe allergy & autoimmunity), using primarily mouse models “humanized” for these components.

2) Establish high-throughput plasma cell screening, analysis and/or sorting using droplet microfluidics technologies to understand the antibody response, repertoire and affinities, and demonstrate the pathogenic nature of antibodies in specific diseases .

3) Develop  clinical studies (NASA; WaspPenIP; ENDOPHEN) to understand how antibodies and their effector functions induce/regulate autoimmune and allergic diseases

4) Develop novel antibody-based therapeutics

Altogether, our research integrating fundamental, clinical and industry-driven approaches, aims at elucidating the role of antibodies, their receptors and the cells expressing them in major disease and therapy models and, hopefully, propose novel therapeutic solutions in antibody-based therapies.

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CONFERENCE ORGANIZATION

Antibodies & Complement conference 2021

May 21 – 25, 2021

Venue: Hotel Eden Roc, Punta Port Salvi s/n, Sant Feliu de Guixols, 17220 Girona, Spain.

Website: https://antibodies-and-complement.org/

The antibody response and the complement system are major effector arms of the immune system. Both have been involved in a plethora of pathological conditions, including autoimmunity, allergy, infections and cancer. Antibodies and complement components regulate, mainly through their receptors (FcR and CR respectively) cell activation, ADCC, ADCP, CDC, CDCP, migration, survival but also, as recently described, metabolism. As the portfolio of antibody—and complement-effector function grow, high-end technological solutions are developed and novel therapeutic applications are proposed.

This 2nd conference on Antibodies & Complement will focus attention on key advances in both fields with the aim at fostering discussions between antibody experts and complement experts. Some of the critical topics to be covered include:

  • antibody & complement (novel) functions
  • human antibody repertoires
  • complement structure and subcellular localization
  • novel technologies
  • complement and antibody therapies

After the success of the first edition and second edition, this 3rd conference on Antibodies & Complement should again be a forum for leaders in the field and new investigators coming from academia, industry and research institutes to discuss where the field is going and what challenges lie ahead.

Contact

Phone: 01 45 68 82 41 Email: daniele.sinnaya@pasteur.fr Address: Unit of Antibodies in Therapy and Pathology, Institut Pasteur, 25 Rue du Docteur Roux 75015, Paris, France.