10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
Ageing & Longevity
According to the WHO, the global percentage of people aged of more than 60 years will double from 11 to 22% between 2000 and 2050. Nowadays most of the elderly die of non-transmissible diseases […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie
Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]
Biomarker discovery and viral disease pathogenesis
Biomarker discovery We are interested in the discovery of biomarkers that can be used to guide the clinical management of patients, and can also inform us about basic disease pathogenesis. The lab’s interest in […]
Milieu Intérieur: Deconvolution of the healthy immune response
Systems approaches for the study of immune signaling pathways have been traditionally based on selected purified cell types or cultured cell lines. However, in vivo responses involve the coordinated action of multiple cell types, […]
Functional immune response to Mycobacteria tuberculosis derived antigen
The objective of our project is to establish feasibility for a new generation of in vitro diagnostic (IVDs) tools, applied to proof-of-concept studies in Mycobacterium tuberculosis (MTB) infected persons and patients with TB disease. […]
2020Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa., 2020 Sep 24;140598..
2020Inborn errors of type I IFN immunity in patients with life-threatening COVID-19., Science 2020 Sep; (): .
2020Auto-antibodies against type I IFNs in patients with life-threatening COVID-19., Science 2020 Sep; (): .
2020Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus., Ann Neurol 2020 Sep; (): .
2020Understanding immune variation for improved translational medicine., Curr. Opin. Immunol. 2020 Jul; 65(): 83-88.
2020Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients., Science 2020 Aug7; 369(6504): 718-724.
2020Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome., J. Clin. Immunol. 2020 Aug; 40(6): 807-819.
2020Catatonia in a patient with Aicardi-Goutières syndrome efficiently treated with immunoadsorption., Schizophr. Res. 2020 Jun; (): .
2020Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes., Diabetologia 2020 Aug; 63(8):1576-1587.
2020Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients., Angiogenesis 2020 Nov;23(4):611-620.
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