Throughout my research career I have been interested in how a better understanding of fundamental immunology can be applied to novel solutions for improving human health. I undertook a PhD in immunological memory, and with progression of my career moved closer to translational research to deliver research findings to the clinic. During my post-doctoral positions I worked on vaccine development projects for HIV and TB to understand how different vaccination strategies impact innate and adaptive immunity. More recently I have focused on biomarkers that are predictive of spontaneous clearance and response to therapy for Hepatitis C patients. This approach is helping us to understand what is required for a protective immune response to HCV while at the same time giving us unique tools to help manage therapeutic decisions. My current focus as scientific manager of the LabEx Milieu Interieur project at Institut Pasteur, Paris is to understand the genetic and environmental determinants of a healthy immune response, and also apply these findings to disease settings to develop new diagnostic and therapeutic approaches.
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Timeline
Courses
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
2018-12-02 09:00:00
2018-12-15 18:00:00
Europe/Paris
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
HKU-Pasteur Research Centre, Hong Kong
Transversal Projects
Projects
CV
Publications
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2020Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes., Diabetologia 2020 Jun; (): .
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2020Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients., Angiogenesis 2020 May; (): .
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2020Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort., Am. J. Clin. Nutr. 2020 May; (): .
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2020The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway, Haematologica 2020 Mar;.
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2020Antibody-coated microbiota in nasopharynx of healthy individuals and hypogammaglobulinemia patients, J. Allergy Clin. Immunol. 2020 Jun;145(6):1686-1690.
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2020Neuromyelitis optica in patients with increased interferon alpha concentrations, Lancet Neurol 2020 01;19(1):31-33.
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2019Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in, Sci Immunol 2019 Dec;4(42).
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2019Cardiac valve involvement in -related type I interferonopathy, J. Med. Genet. 2019 Nov;.
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2019PSMB10, the last immunoproteasome gene missing for PRAAS, J. Allergy Clin. Immunol. 2020 Mar;145(3):1015-1017.
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2019Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling, Rheumatology (Oxford) 2019 Nov;.
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