Darragh Duffy leads the Translational Immunology lab at the Institut Pasteur, Paris and is co-coordinator of the LabEx Milieu Interieur project. The overall goal of his research is to better understand the fundamental mechanisms behind inter-individual differences in immune responses, and apply these discoveries to relevant clinical questions. To do this they use cellular mechanistic models, population immunology cohorts, and experimental clinical studies in infection and autoimmunity. They work closely with clinical collaborators with the goal that the research findings will help to develop new patient management strategies. For fundamental questions related to understanding immune variability they apply systems immunology approaches to diverse phenotypes and integrate with genetic and environmental factors.
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
Ageing & Longevity
According to the WHO, the global percentage of people aged of more than 60 years will double from 11 to 22% between 2000 and 2050. Nowadays most of the elderly die of non-transmissible diseases […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
Deciphering the causes of Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie
Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]
Biomarker discovery and viral disease pathogenesis
Biomarker discovery We are interested in the discovery of biomarkers that can be used to guide the clinical management of patients, and can also inform us about basic disease pathogenesis. The lab’s interest in […]
Milieu Intérieur: Deconvolution of the healthy immune response
Systems approaches for the study of immune signaling pathways have been traditionally based on selected purified cell types or cultured cell lines. However, in vivo responses involve the coordinated action of multiple cell types, […]
Functional immune response to Mycobacteria tuberculosis derived antigen
The objective of our project is to establish feasibility for a new generation of in vitro diagnostic (IVDs) tools, applied to proof-of-concept studies in Mycobacterium tuberculosis (MTB) infected persons and patients with TB disease. […]
2022Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity., Nat Commun 2022 Nov; 13(1): 7254.
2022Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort., Cell Rep Med 2022 Nov; 3(11): 100804.
2022The immune factors driving DNA methylation variation in human blood., Nat Commun 2022 Oct; 13(1): 5895.
2022Variability of Primary Sjögren’s Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA-DQ Locus., Arthritis Rheumatol 2022 Jun; (): .
2022Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming., Ann Rheum Dis 2022 Jun; (): .
2022The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies., Proc Natl Acad Sci U S A 2022 05; 119(21): e2200413119.
2022CXCR3 Expression Pattern on CD4+ T Cells and IP-10 Levels with Regard to the HIV-1 Reservoir in the Gut-Associated Lymphatic Tissue., Pathogens 2022 Apr; 11(4): .
2022Activation of NLRP3 Inflammasome in the Skin of Patients with Systemic and Cutaneous Lupus Erythematosus., Acta Derm Venereol 2022 Mar; (): .
2022Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes., Genome Med 2022 03; 14(1): 28.
2022Efficacy and tolerance of corticosteroids and methotrexate in patients with juvenile dermatomyositis: a retrospective cohort study., Rheumatology (Oxford) 2022 Feb; (): .
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