Throughout my research career I have been interested in how a better understanding of fundamental immunology can be applied to novel solutions for improving human health. I undertook a PhD in immunological memory, and with progression of my career moved closer to translational research to deliver research findings to the clinic. During my post-doctoral positions I worked on vaccine development projects for HIV and TB to understand how different vaccination strategies impact innate and adaptive immunity. More recently I have focused on biomarkers that are predictive of spontaneous clearance and response to therapy for Hepatitis C patients. This approach is helping us to understand what is required for a protective immune response to HCV while at the same time giving us unique tools to help manage therapeutic decisions. My current focus as scientific manager of the LabEx Milieu Interieur project at Institut Pasteur, Paris is to understand the genetic and environmental determinants of a healthy immune response, and also apply these findings to disease settings to develop new diagnostic and therapeutic approaches.
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Timeline
Courses
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
2018-12-02 09:00:00
2018-12-15 18:00:00
Europe/Paris
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
HKU-Pasteur Research Centre, Hong Kong
Transversal Projects
Projects
CV
Publications
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2019Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus, J. Invest. Dermatol. 2019 Apr;.
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2019Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS, J. Exp. Med. 2019 Apr;.
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2019Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined, Eur. J. Immunol. 2019 May;49(5):790-800.
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2019Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth, Nat. Immunol. 2019 Mar;20(3):257-264.
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2018Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome, N. Engl. J. Med. 2018 12;379(23):2275-7.
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2018A child with severe juvenile dermatomyositis treated with ruxolitinib, Brain 2018 Nov;141(11):e80.
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2018Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency, Ann. Rheum. Dis. 2018 Oct;.
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2018Immune response biomarkers in human and veterinary research, Comp. Immunol. Microbiol. Infect. Dis. 2018 Aug;59:57-62.
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2018Potential utility of the Genedrive point-of-care test for HCV RNA detection, Gut 2018 Sep;.
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2018First description of agonist and antagonist IP-10 in urine of patients with active TB, Int. J. Infect. Dis. 2019 Jan;78:15-21.
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