Darragh Duffy leads the Translational Immunology lab at the Institut Pasteur, Paris and is co-coordinator of the LabEx Milieu Interieur project. The overall goal of his research is to better understand the fundamental mechanisms behind inter-individual differences in immune responses, and apply these discoveries to relevant clinical questions. To do this they use cellular mechanistic models, population immunology cohorts, and experimental clinical studies in infection and autoimmunity. They work closely with clinical collaborators with the goal that the research findings will help to develop new patient management strategies. For fundamental questions related to understanding immune variability they apply systems immunology approaches to diverse phenotypes and integrate with genetic and environmental factors.
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
Ageing & Longevity
According to the WHO, the global percentage of people aged of more than 60 years will double from 11 to 22% between 2000 and 2050. Nowadays most of the elderly die of non-transmissible diseases […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
Deciphering the causes of Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie
Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]
Biomarker discovery and viral disease pathogenesis
Biomarker discovery We are interested in the discovery of biomarkers that can be used to guide the clinical management of patients, and can also inform us about basic disease pathogenesis. The lab’s interest in […]
Milieu Intérieur: Deconvolution of the healthy immune response
Systems approaches for the study of immune signaling pathways have been traditionally based on selected purified cell types or cultured cell lines. However, in vivo responses involve the coordinated action of multiple cell types, […]
Functional immune response to Mycobacteria tuberculosis derived antigen
The objective of our project is to establish feasibility for a new generation of in vitro diagnostic (IVDs) tools, applied to proof-of-concept studies in Mycobacterium tuberculosis (MTB) infected persons and patients with TB disease. […]
2021Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers., J Exp Med 2021 Jan; 218(1): .
2020Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo., Ann Rheum Dis 2021;80:475-486.
2020JAK Inhibition in the Aicardi-Goutières Syndrome., N Engl J Med 2020 11; 383(22): 2190-2191.
2020Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling., J. Exp. Med. 2020 Nov; 217(11): .
2020Immune profiling enables stratification of patients with active TB disease or M. tuberculosis infection., Clin Infect Dis 2020 Oct; (): .
2020Interleukin-7/Interferon axis drives T-cell and salivary gland epithelial cell interactions in Sjögren’s syndrome., Arthritis Rheumatol 2020 Oct; (): .
2020Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa., 2020 Sep 24;140598..
2020Inborn errors of type I IFN immunity in patients with life-threatening COVID-19., Science 2020 Oct 23; 370(6515): eabd4570.
2020Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science 2020 10; 370(6515): .
2020Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus., Ann Neurol 2020 dec; 88(6): 1244-1250.
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