Throughout my research career I have been interested in how a better understanding of fundamental immunology can be applied to novel solutions for improving human health. I undertook a PhD in immunological memory, and with progression of my career moved closer to translational research to deliver research findings to the clinic. During my post-doctoral positions I worked on vaccine development projects for HIV and TB to understand how different vaccination strategies impact innate and adaptive immunity. More recently I have focused on biomarkers that are predictive of spontaneous clearance and response to therapy for Hepatitis C patients. This approach is helping us to understand what is required for a protective immune response to HCV while at the same time giving us unique tools to help manage therapeutic decisions. My current focus as scientific manager of the LabEx Milieu Interieur project at Institut Pasteur, Paris is to understand the genetic and environmental determinants of a healthy immune response, and also apply these findings to disease settings to develop new diagnostic and therapeutic approaches.
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
Biomarker discovery and viral disease pathogenesis
Biomarker discovery We are interested in the discovery of biomarkers that can be used to guide the clinical management of patients, and can also inform us about basic disease pathogenesis. The lab’s interest […]
Milieu Intérieur: Deconvolution of the healthy immune response
Systems approaches for the study of immune signaling pathways have been traditionally based on selected purified cell types or cultured cell lines. However, in vivo responses involve the coordinated action of multiple cell types, […]
Functional immune response to Mycobacteria tuberculosis derived antigen
The objective of our project is to establish feasibility for a new generation of in vitro diagnostic (IVDs) tools, applied to proof-of-concept studies in Mycobacterium tuberculosis (MTB) infected persons and patients with TB disease. […]
2018Human thymopoiesis is influenced by a common genetic variant within the locus, Sci Transl Med 2018 Sep;10(457).
2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines, Genome Med 2018 Jul;10(1):59.
2018Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses, Elife 2018 Jun;7.
2018JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis, Brain 2018 Jun;141(6):1609-1621.
2018Comment on: ‘Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors’ by Giannelou : mutations in result in a constitutive activation of type I interferon signalling, Ann. Rheum. Dis. 2018 Jun;.
2018Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies, Hum Vaccin Immunother 2018 May;:1-9.
2018Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus, Gut 2018 Apr;.
2018T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation, Eur. Respir. J. 2018 Mar;51(3).
2018Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors, Nat. Immunol. 2018 Mar;19(3):302-314.
2017Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges, Proc. Natl. Acad. Sci. U.S.A. 2018 01;115(3):E488-E497.
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