Throughout my research career I have been interested in how a better understanding of fundamental immunology can be applied to novel solutions for improving human health. I undertook a PhD in immunological memory, and with progression of my career moved closer to translational research to deliver research findings to the clinic. During my post-doctoral positions I worked on vaccine development projects for HIV and TB to understand how different vaccination strategies impact innate and adaptive immunity. More recently I have focused on biomarkers that are predictive of spontaneous clearance and response to therapy for Hepatitis C patients. This approach is helping us to understand what is required for a protective immune response to HCV while at the same time giving us unique tools to help manage therapeutic decisions. My current focus as scientific manager of the LabEx Milieu Interieur project at Institut Pasteur, Paris is to understand the genetic and environmental determinants of a healthy immune response, and also apply these findings to disease settings to develop new diagnostic and therapeutic approaches.
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Timeline
Courses
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
2018-12-02 09:00:00
2018-12-15 18:00:00
Europe/Paris
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
HKU-Pasteur Research Centre, Hong Kong
Transversal Projects
Projects
CV
Publications
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2019Circulating interferon-α measured with a highly sensitive assay as a biomarker for juvenile inflammatory myositis activity, 2019 Sep;.
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2019Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment, Sci Adv 2019 Jul;5(7):eaav9019.
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2019A Call for Blood-In Human Immunology, Immunity 2019 Jun;50(6):1335-1336.
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2019Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles, Arthritis Res. Ther. 2019 Jun;21(1):147.
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2019Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection, JCI Insight 2019 July;4(13):e122998.
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2019IP-10 contributes to the inhibition of mycobacterial growth in an ex vivo whole blood assay, Int. J. Med. Microbiol. 2019;309:299-306.
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2019Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions, Acta Derm. Venereol. 2019 99:789-796.
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2019Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus, J. Invest. Dermatol. 2019 139:2058-2061.
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2019Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS, J. Exp. Med. 2019 May 6;216(5):1199-1213.
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2019Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined, Eur. J. Immunol. 2019 May;49(5):790-800.
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