Throughout my research career I have been interested in how a better understanding of fundamental immunology can be applied to novel solutions for improving human health. I undertook a PhD in immunological memory, and with progression of my career moved closer to translational research to deliver research findings to the clinic. During my post-doctoral positions I worked on vaccine development projects for HIV and TB to understand how different vaccination strategies impact innate and adaptive immunity. More recently I have focused on biomarkers that are predictive of spontaneous clearance and response to therapy for Hepatitis C patients. This approach is helping us to understand what is required for a protective immune response to HCV while at the same time giving us unique tools to help manage therapeutic decisions. My current focus as scientific manager of the LabEx Milieu Interieur project at Institut Pasteur, Paris is to understand the genetic and environmental determinants of a healthy immune response, and also apply these findings to disease settings to develop new diagnostic and therapeutic approaches.
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie
Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]
Biomarker discovery and viral disease pathogenesis
Biomarker discovery We are interested in the discovery of biomarkers that can be used to guide the clinical management of patients, and can also inform us about basic disease pathogenesis. The lab’s interest in […]
Milieu Intérieur: Deconvolution of the healthy immune response
Systems approaches for the study of immune signaling pathways have been traditionally based on selected purified cell types or cultured cell lines. However, in vivo responses involve the coordinated action of multiple cell types, […]
Functional immune response to Mycobacteria tuberculosis derived antigen
The objective of our project is to establish feasibility for a new generation of in vitro diagnostic (IVDs) tools, applied to proof-of-concept studies in Mycobacterium tuberculosis (MTB) infected persons and patients with TB disease. […]
2019Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth, Nat. Immunol. 2019 Mar;20(3):257-264.
2018Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome, N. Engl. J. Med. 2018 12;379(23):2275-7.
2018A child with severe juvenile dermatomyositis treated with ruxolitinib, Brain 2018 Nov;141(11):e80.
2018Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency, Ann. Rheum. Dis. 2018 Oct;.
2018Immune response biomarkers in human and veterinary research, Comp. Immunol. Microbiol. Infect. Dis. 2018 Aug;59:57-62.
2018Potential utility of the Genedrive point-of-care test for HCV RNA detection, Gut 2018 Sep;.
2018First description of agonist and antagonist IP-10 in urine of patients with active TB, Int. J. Infect. Dis. 2019 Jan;78:15-21.
2018Human thymopoiesis is influenced by a common genetic variant within the locus, Sci Transl Med 2018 Sep;10(457).
2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines, Genome Med 2018 07;10(1):59.
2018Mitochondrial double-stranded RNA triggers antiviral signalling in humans, Nature 2018 08;560(7717):238-242.
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