Throughout my research career I have been interested in how a better understanding of fundamental immunology can be applied to novel solutions for improving human health. I undertook a PhD in immunological memory, and with progression of my career moved closer to translational research to deliver research findings to the clinic. During my post-doctoral positions I worked on vaccine development projects for HIV and TB to understand how different vaccination strategies impact innate and adaptive immunity. More recently I have focused on biomarkers that are predictive of spontaneous clearance and response to therapy for Hepatitis C patients. This approach is helping us to understand what is required for a protective immune response to HCV while at the same time giving us unique tools to help manage therapeutic decisions. My current focus as scientific manager of the LabEx Milieu Interieur project at Institut Pasteur, Paris is to understand the genetic and environmental determinants of a healthy immune response, and also apply these findings to disease settings to develop new diagnostic and therapeutic approaches.
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Timeline
Courses
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
2018-12-02 09:00:00
2018-12-15 18:00:00
Europe/Paris
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
HKU-Pasteur Research Centre, Hong Kong
Program Projects
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CV
Publications
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2018Human thymopoiesis is influenced by a common genetic variant within the locus, Sci Transl Med 2018 Sep;10(457).
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2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines, Genome Med 2018 Jul;10(1):59.
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2018Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses, Elife 2018 Jun;7.
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2018JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis, Brain 2018 Jun;141(6):1609-1621.
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2018Comment on: ‘Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors’ by Giannelou : mutations in result in a constitutive activation of type I interferon signalling, Ann. Rheum. Dis. 2018 Jun;.
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2018Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies, Hum Vaccin Immunother 2018 May;:1-9.
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2018Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus, Gut 2018 Apr;.
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2018T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation, Eur. Respir. J. 2018 Mar;51(3).
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2018Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors, Nat. Immunol. 2018 Mar;19(3):302-314.
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2017Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges, Proc. Natl. Acad. Sci. U.S.A. 2018 01;115(3):E488-E497.
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