Gérard Eberl

Deputy Director

Ana Cumano

Deputy Director

Pierre Bruhns


It is possible to state as a general principle that the mesodermic phagocytes, which originally (as in the sponges of our days) acted as digestive cells, retained their role to absorb the dead or weakened parts of the organism as much as different foreign intruders.
Elie Metchnikoff, 1884

Pasteur and Koch demonstrated that microbes can be vectors of diseases. A few years later, Metchnikoff and Ehrlich showed that we are protected from microbes by an immune system. Ever since, immunologists have worked to understand how the immune system identifies and eliminates pathogens, at all levels of molecular, cellular and physiologic complexity. The Department of Immunology, which includes 14 research units and 166 scientists, has a shared interest in exploring the fundamental processes of immunity with the hope to provide new insight into disease pathogenesis, inspire novel vaccines and design unique therapeutic strategies. Moreover, the scientists of the Department share a commitment to training the next generation of scientists dedicated to research excellence in the field of immunology.

Research conducted in the Department is organized into three main themes:

Development of the immune system

From the earliest hematopoietic precursors which appear in the yolk sac to the organization of lymphoid tissues, the competition for unique niche and resources that define the immune repertoire and the mechanisms that ensure homeostasis – the development of the immune system is intricately linked to our relationship with symbiotic microbes and its ability to respond to infectious agents and malignant transformation. Research units headed by Ana Cumano, James Di Santo, Gerard Eberl, Ludovic Deriano and Antonio Freitas are helping to advance our understanding in these areas.

Innate and adaptive immune responses.

Spanning from cell trafficking, proliferation and differentiation during host response to the signaling pathways that regulate these processes – the understanding of how the innate and adaptive immune responses function requires a coordinated effort employing cutting-edge biochemical, imaging and cell physiology approaches. Research units headed by Andres Alcover, Philippe Bousso, Pierre Bruhns, Caroline Demangel and Sandra Pellegrini have been providing critical information into the cross-talk between the two arms of our immune system, as well as the mechanisms by which micro-organisms subvert the host response for their own benefit.

Immune pathology and Immunotherapy.

The immune response is often referred to as a double-edged sword, pathogenic in the case of chronic infection and autoimmunity, but protective in its control of cells undergoing malignant transformation or in the case of vaccination. Research units headed by Matthew Albert, Claude Leclerc, Hugo Mouquet and Lars Rogge investigate the regulation of immunity in disease with the aim to translate their research into new diagnostic and therapeutic modalities.

Research in the department is highly collaborative, with its programs not only cutting across the stated thematic areas, but also forging important links to virology, bacteriology, parasitology, cell biology, genetics, developmental biology, neurology and epidemiology.

As part of a century-long commitment to understanding host immunity, the Department has taken the lead in training the future generations of immunologists. Notably, members of the department organize what is considered the top Immunology Masters course in France, attracting students from all over the world, who benefit from lectures in fundamental and applied immunology. Research Units within the department also welcome masters, graduate and post-doctoral students. Currently there are 34 students, at different stages of their training.

The Department of Immunology would like to thank its generous sponsors, whose support enables to maintain a robust academic environment within the department.





Department direction

Gérard Eberl: Department director

Ana Cumano: Deputy director for human affairs

Pierre Bruhns: Deputy director for technological affairs

Marie-laure Goupil: Department secretary


Chercheurs A

Titulaire : Paulo VIEIRA

Suppléante : Frédérique MICHEL

Chercheurs B

Titulaire : Elisabetta BIANCHI

Suppléante : Friederike JONSSON

Chercheurs post-doctorants

Titulaires : Cécile ALANIO et AYRIN KOK HARUNOVA

Suppléant : Grégoire CHEVALIER


Titulaires : Joy BIANCHI et Caitlin GILLIS

Suppléant :


Titulaires : Hélène SAKLANI et Marie BEDORA-FAURE

Suppléante : Odile BURLEN-DEFRANOUX


Titulaire : Odile RICHARD LE-GOFF

Suppléante : Béatrice CORRE


Titulaire : Bérengère HUGOT

Suppléante : Marie-Laure GOUPIL

Lab Heads

Matthew Albert

CRT Executive committee

Industrial collaborations & carriers

Andres Alcover

Conseil Scientifique
Immunology course
Assemblée des 100
Pasteur-Weizmann council

Philippe Bousso

Pasteur-Weizmann council
ITMO IHP Scientific advisor 
BioSPC administrative council

Pierre Bruhns

COMESP (-2015)

Ana Cumano

Cytometry, Scientific Coordinator
Immunology course

Caroline Demangel

Department animation (seminars, WIPs)

COMESP (Sous-commission 3)

Ludovic Deriano

MAASCC coordination


James Di Santo

Counsellor to President
COMESP (-2015)


Gérard Eberl

GPF Microbes & Brain Board
Gnotobiology, Scientific Coordinator


Claude Leclerc

Conseil Administration
GPF Vaccinology Board
Canceropôle Ile de France


Hugo Mouquet

MAASCC coordination

CRT Executive committee


Sandra Pellegrini

Equipment for department (public, private)
Erasmus students coordination


Lars Rogge

CRT Steering committee




research.pasteur.fr_elisabetta-bianchi-150x150Elisabetta Bianchi

Erasmus students coordination
COMESP (suppléante)


BBBéatrice Bréart


research.pasteur.fr_sc-150x150Susanna Celli

PPU Dean

research.pasteur.fr_ha5-150x150Gilles Dadaglio


V de Bartolo2

Vincenzo di Bartolo

COMESP (sous-commission 3)


Darragh Duffy

LabEx Milieu Intérieur, Scientific manager

francoiscvFrançois Huetz

SFI administrative council

Milena Hasan, ingÈnieur ‡ l'Institut Pasteur, responsable de la plate-forme "Centre d'immunologie humaine (CIH)" depuis fÈvrier 2015.Milena Hasan

CIH, Director

COMESP (Sous-commission 3)


Molly Ingersoll

PPU board
Immunology course (travaux pratiques)


Friederike Jönsson

PhD graduation Ceremony

Photo du 20-10-15 à 18.21 #2

Hélène Saklani

Assemblée des 100

COMESP (Sous-commission 3)


Hélène Strick M.

Comité utilisateurs A3

COMESP (Sous-commission 3)


Paulo Vieira

Assemblée des 100
PPU Board

COMESP (Sous-commission 3)


Christian Vosshenrich

Immunology course




The aim of Thematic Interest Groups, or TIGs, is to build on existing affinities between people and research interests to develop the scientific policy of the department of immunology. By including members beyond the department and the Institut Pasteur, TIGs also aim to develop a synergistic policy with partners  at different centers in Paris and France. The following TIGs are currently in development:

  1. Mucosal Immunology: Gérard, Jim, Ivo Boneca, Marc Lecuit, Armelle Phalipon, Nadine Cerf Bensussan (Imagine), Jamila Faivre (Paul Brousse)
  2. Cancer: Ludovic, Lucie, Philippe, Matthew, Claude, Gilles, Andres
  3. Development: Ana, Jim, Rachel, Lucie, Paolo, Elisa Perdiguero Gomez
  4. B cells: Hugo, Pierre, Paolo, François Huetz
  5. Epigenetics: Jim, Lars, Ludovic, Elisabetta, Jessica Quintin, Mélanie Hamon, Anne Dejean, François Spitz
  6. Metabolism: Caroline,
  7. Vaccinology: Claude, Armelle, Frederic (Tangy)
  8. Human immunology: Lars, Richard, Matthew, Jim, Elisabetta, Sandra
Mucosal Immunology

The TIG Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It is build on a Mucosal Immunology Club that exists since 2012 and meets once a month to discuss new data presented by one of the labs, in turns. The MI TIG focuses on all potential aspects of mucosal immunology and microbiology, and the impact of these local processes on physiology. Please contact Gérard Eberl if you wish to participate to the MI TIG.


Gérard Eberl



Microenvironment and Immunity, Department of Immunology

jim-di-santo-1 Jim di Santo

Innate Immunity, Department of Immunology


research.pasteur.fr_ipp6314-150x150  Ivo Boneca

Biology of Genetics and Bactérial Cell Wall, Department of Microbiology

research.pasteur.fr_research.pasteur.fr_sans-titre41-150x150 Marc Lecuit Biology  of Infection, départment of Infection and Epidémiology
Portrait_Armelle  Armelle Phalipon

Molecular Microbial Pathogenesis, Department of Cell Biology and Infection

Cerf-BensussanNadine_01-1 Nadine Cerf-Bensussan         

Laboratory of intestinal immunity, Institut Imagine, Necker

 jamilafaivre Jamila Faivre

Hepatobiliary Center at the Paul Brousse Hospital.

B-cell and antibodies

Hugo Mouquet



Humoral Response to Pathogens, Department of Immunology 

 research.pasteur.fr_paulo-vieira-150x150 Paulo Vieira  

Lymphopoiesis, Department of Immunology 

 2f2dd2a Pierre Bruhns  

Antibodies in Therapy and Pathology, Department of Immunology 

 francoiscv François Huetz

Department of Immunology

Immunology, infectiology and Haematology, Necker

 research.pasteur.fr_deriano-150x150 Ludovic Deriano  

Lymphocyte Development and Oncogenesis, Department of Immunology 


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