Department

Immunology

Director

Gérard Eberl

Deputy Director

Ana Cumano

Deputy Director

Pierre Bruhns

Research

It is possible to state as a general principle that the mesodermic phagocytes, which originally (as in the sponges of our days) acted as digestive cells, retained their role to absorb the dead or weakened parts of the organism as much as different foreign intruders.
Elie Metchnikoff, 1884

Pasteur and Koch demonstrated that microbes can be vectors of diseases. A few years later, Metchnikoff and Ehrlich showed that we are protected from microbes by an immune system. Ever since, immunologists have worked to understand how the immune system identifies and eliminates pathogens, at all levels of molecular, cellular and physiologic complexity. The Department of Immunology, which includes 14 research units and 166 scientists, has a shared interest in exploring the fundamental processes of immunity with the hope to provide new insight into disease pathogenesis, inspire novel vaccines and design unique therapeutic strategies. Moreover, the scientists of the Department share a commitment to training the next generation of scientists dedicated to research excellence in the field of immunology.

Research conducted in the Department is organized into three main themes:

Development of the immune system

From the earliest hematopoietic precursors which appear in the yolk sac to the organization of lymphoid tissues, the competition for unique niche and resources that define the immune repertoire and the mechanisms that ensure homeostasis – the development of the immune system is intricately linked to our relationship with symbiotic microbes and its ability to respond to infectious agents and malignant transformation. Research units headed by Ana Cumano, James Di Santo, Gerard Eberl, Ludovic Deriano and Antonio Freitas are helping to advance our understanding in these areas.

Innate and adaptive immune responses.

Spanning from cell trafficking, proliferation and differentiation during host response to the signaling pathways that regulate these processes – the understanding of how the innate and adaptive immune responses function requires a coordinated effort employing cutting-edge biochemical, imaging and cell physiology approaches. Research units headed by Andres Alcover, Philippe Bousso, Pierre Bruhns, Caroline Demangel and Sandra Pellegrini have been providing critical information into the cross-talk between the two arms of our immune system, as well as the mechanisms by which micro-organisms subvert the host response for their own benefit.

Immune pathology and Immunotherapy.

The immune response is often referred to as a double-edged sword, pathogenic in the case of chronic infection and autoimmunity, but protective in its control of cells undergoing malignant transformation or in the case of vaccination. Research units headed by Matthew Albert, Claude Leclerc, Hugo Mouquet and Lars Rogge investigate the regulation of immunity in disease with the aim to translate their research into new diagnostic and therapeutic modalities.

Research in the department is highly collaborative, with its programs not only cutting across the stated thematic areas, but also forging important links to virology, bacteriology, parasitology, cell biology, genetics, developmental biology, neurology and epidemiology.

As part of a century-long commitment to understanding host immunity, the Department has taken the lead in training the future generations of immunologists. Notably, members of the department organize what is considered the top Immunology Masters course in France, attracting students from all over the world, who benefit from lectures in fundamental and applied immunology. Research Units within the department also welcome masters, graduate and post-doctoral students. Currently there are 34 students, at different stages of their training.

The Department of Immunology would like to thank its generous sponsors, whose support enables to maintain a robust academic environment within the department.

News

Teams

Jobs

TASKS

Department direction

Gérard Eberl: Department director

Ana Cumano: Deputy director for human affairs

Pierre Bruhns: Deputy director for technological affairs

Marie-laure Goupil: Department secretary

Representatives

Chercheurs A

Titulaire : Paulo VIEIRA

Suppléante : Frédérique MICHEL

Chercheurs B

Titulaire : Elisabetta BIANCHI

Suppléante : Friederike JONSSON

Chercheurs post-doctorants

Titulaires : Cécile ALANIO et AYRIN KOK HARUNOVA

Suppléant : Grégoire CHEVALIER

Doctorants

Titulaires : Joy BIANCHI et Caitlin GILLIS

Suppléant :

Ingénieurs

Titulaires : Hélène SAKLANI et Marie BEDORA-FAURE

Suppléante : Odile BURLEN-DEFRANOUX

Techniciens

Titulaire : Odile RICHARD LE-GOFF

Suppléante : Béatrice CORRE

Secrétaires

Titulaire : Bérengère HUGOT

Suppléante : Marie-Laure GOUPIL

Lab Heads

Matthew Albert

CRT Executive committee

Industrial collaborations & carriers

Andres Alcover

Conseil Scientifique
Immunology course
Assemblée des 100
Pasteur-Weizmann council

Philippe Bousso

COMESP
Pasteur-Weizmann council
ITMO IHP Scientific advisor 
BioSPC administrative council

Pierre Bruhns

CITECH Board
COMESP (-2015)

Ana Cumano

Cytometry, Scientific Coordinator
Immunology course

Caroline Demangel

Department animation (seminars, WIPs)

COMESP (Sous-commission 3)

Ludovic Deriano

MAASCC coordination

Bioinformatics

James Di Santo

Counsellor to President
COMESP (-2015)

 

Gérard Eberl

GPF Microbes & Brain Board
Gnotobiology, Scientific Coordinator

 

Claude Leclerc

Conseil Administration
GPF Vaccinology Board
Canceropôle Ile de France

 

Hugo Mouquet

MAASCC coordination

CRT Executive committee

 

Sandra Pellegrini

Equipment for department (public, private)
Erasmus students coordination

 

Lars Rogge

CRT Steering committee

 

 

 
Chercheurs/ingénieurs/OREX

research.pasteur.fr_elisabetta-bianchi-150x150Elisabetta Bianchi

Bioinformatics
Erasmus students coordination
COMESP (suppléante)

COPIL C3BI

BBBéatrice Bréart

CETEA

research.pasteur.fr_sc-150x150Susanna Celli

PPU Dean

research.pasteur.fr_ha5-150x150Gilles Dadaglio

CETEA

V de Bartolo2

Vincenzo di Bartolo

COMESP (sous-commission 3)

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Darragh Duffy

LabEx Milieu Intérieur, Scientific manager

francoiscvFrançois Huetz

COMESP
SFI administrative council

Milena Hasan, ingÈnieur ‡ l'Institut Pasteur, responsable de la plate-forme "Centre d'immunologie humaine (CIH)" depuis fÈvrier 2015.Milena Hasan

CIH, Director

COMESP (Sous-commission 3)

research.pasteur.fr_icdphoto

Molly Ingersoll

PPU board
Immunology course (travaux pratiques)

research.pasteur.fr_freddie-150x150

Friederike Jönsson

PhD graduation Ceremony

Photo du 20-10-15 à 18.21 #2

Hélène Saklani

Assemblée des 100

COMESP (Sous-commission 3)

research.pasteur.fr_helena-150x150

Hélène Strick M.

Comité utilisateurs A3

COMESP (Sous-commission 3)

 research.pasteur.fr_paulo-vieira-150x150

Paulo Vieira

Assemblée des 100
PPU Board

COMESP (Sous-commission 3)

research.pasteur.fr_c-vossenrich-150x150

Christian Vosshenrich

CETEA
Bioinformatics
Immunology course

COPIL C3BI

 

TIGS

The aim of Thematic Interest Groups, or TIGs, is to build on existing affinities between people and research interests to develop the scientific policy of the department of immunology. By including members beyond the department and the Institut Pasteur, TIGs also aim to develop a synergistic policy with partners  at different centers in Paris and France. The following TIGs are currently in development:

  1. Mucosal Immunology: Gérard, Jim, Ivo Boneca, Marc Lecuit, Armelle Phalipon, Nadine Cerf Bensussan (Imagine), Jamila Faivre (Paul Brousse)
  2. Cancer: Ludovic, Lucie, Philippe, Matthew, Claude, Gilles, Andres
  3. Development: Ana, Jim, Rachel, Lucie, Paolo, Elisa Perdiguero Gomez
  4. B cells: Hugo, Pierre, Paolo, François Huetz
  5. Epigenetics: Jim, Lars, Ludovic, Elisabetta, Jessica Quintin, Mélanie Hamon, Anne Dejean, François Spitz
  6. Metabolism: Caroline,
  7. Vaccinology: Claude, Armelle, Frederic (Tangy)
  8. Human immunology: Lars, Richard, Matthew, Jim, Elisabetta, Sandra
 
Mucosal Immunology

The TIG Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It is build on a Mucosal Immunology Club that exists since 2012 and meets once a month to discuss new data presented by one of the labs, in turns. The MI TIG focuses on all potential aspects of mucosal immunology and microbiology, and the impact of these local processes on physiology. Please contact Gérard Eberl if you wish to participate to the MI TIG.

GE-March12s

Gérard Eberl

(Leader)

 

Microenvironment and Immunity, Department of Immunology

jim-di-santo-1 Jim di Santo

Innate Immunity, Department of Immunology

 

research.pasteur.fr_ipp6314-150x150  Ivo Boneca

Biology of Genetics and Bactérial Cell Wall, Department of Microbiology

research.pasteur.fr_research.pasteur.fr_sans-titre41-150x150 Marc Lecuit Biology  of Infection, départment of Infection and Epidémiology
Portrait_Armelle  Armelle Phalipon

Molecular Microbial Pathogenesis, Department of Cell Biology and Infection

Cerf-BensussanNadine_01-1 Nadine Cerf-Bensussan         

Laboratory of intestinal immunity, Institut Imagine, Necker

 jamilafaivre Jamila Faivre

Hepatobiliary Center at the Paul Brousse Hospital.

 
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Hugo Mouquet

(Leader)

 

Humoral Response to Pathogens, Department of Immunology 

 research.pasteur.fr_paulo-vieira-150x150 Paulo Vieira  

Lymphopoiesis, Department of Immunology 

 2f2dd2a Pierre Bruhns  

Antibodies in Therapy and Pathology, Department of Immunology 

 francoiscv François Huetz

Department of Immunology

Immunology, infectiology and Haematology, Necker

 research.pasteur.fr_deriano-150x150 Ludovic Deriano  

Lymphocyte Development and Oncogenesis, Department of Immunology 

Equipment

EQUIPMENT ROOM PERSON IN CHARGE UNIT
 
     
– 2 FLOOR      
Odissey (scanner infrared) 211 Deshmukh Gopaul Bacterial Genome Pasticity
Storm 860 (phosphoimager) 211 Deshmukh Gopaul Bacterial Genome Pasticity
Ultracentifuge Beckman L100XP 203 Rémi Fronzes G5 Structural Biology of Bactérial Secretion
Ultracentifuge Beckman L70 203 Annick Dujeancourt G5 Structural Biology of Bactérial Secretion
Cryostat Leica CM3050S – 2 Sophie Dulauroy  Microenvironment and immunity
Développeuse Kodak site – 2    
CONGELATEURS DE SECOURS 217    
       
 2nd FLOOR      
Spectrophotometre à filtres 2030    
Multiskan spectro monochromateur 200-1000nm 2030    
Skatron collecteur 3H pour p96 2037   Immune Regulation and Vaccinology
Compteur beta Trilux 2037 Catherine Fayolle Immune Regulation and Vaccinology
Camera UV 2051 Marine Oberkampf de Dabrun Immune Regulation and Vaccinology
 3rd  FLOOR      
Ultracentri TL100   Annick Dujeancourt

G5  Structural Biology of Bactérial Secretion

Nanodrop ND 1000 3040    

Featured Publications