It is possible to state as a general principle that the mesodermic phagocytes, which originally (as in the sponges of our days) acted as digestive cells, retained their role to absorb the dead or weakened parts of the organism as much as different foreign intruders.
Elie Metchnikoff, 1884

Pasteur and Koch demonstrated that microbes can be vectors of diseases. A few years later, Metchnikoff and Ehrlich showed that we are protected from microbes by an immune system. Ever since, immunologists have worked to understand how the immune system identifies and eliminates pathogens, at all levels of molecular, cellular and physiologic complexity. The Department of Immunology, which includes 14 research units and 166 scientists, has a shared interest in exploring the fundamental processes of immunity with the hope to provide new insight into disease pathogenesis, inspire novel vaccines and design unique therapeutic strategies. Moreover, the scientists of the Department share a commitment to training the next generation of scientists dedicated to research excellence in the field of immunology.

Research conducted in the Department is organized into three main themes:

Development of the immune system

From the earliest hematopoietic precursors which appear in the yolk sac to the organization of lymphoid tissues, the competition for unique niche and resources that define the immune repertoire and the mechanisms that ensure homeostasis – the development of the immune system is intricately linked to our relationship with symbiotic microbes and its ability to respond to infectious agents and malignant transformation. Research units headed by Ana Cumano, James Di Santo, Gerard Eberl, Ludovic Deriano and Antonio Freitas are helping to advance our understanding in these areas.

Innate and adaptive immune responses.

Spanning from cell trafficking, proliferation and differentiation during host response to the signaling pathways that regulate these processes – the understanding of how the innate and adaptive immune responses function requires a coordinated effort employing cutting-edge biochemical, imaging and cell physiology approaches. Research units headed by Andres Alcover, Philippe Bousso, Pierre Bruhns, Caroline Demangel and Sandra Pellegrini have been providing critical information into the cross-talk between the two arms of our immune system, as well as the mechanisms by which micro-organisms subvert the host response for their own benefit.

Immune pathology and Immunotherapy.

The immune response is often referred to as a double-edged sword, pathogenic in the case of chronic infection and autoimmunity, but protective in its control of cells undergoing malignant transformation or in the case of vaccination. Research units headed by Matthew Albert, Claude Leclerc, Hugo Mouquet, Lucie Peduto and Lars Rogge investigate the regulation of immunity in disease with the aim to translate their research into new diagnostic and therapeutic modalities.

Research in the department is highly collaborative, with its programs not only cutting across the stated thematic areas, but also forging important links to virology, bacteriology, parasitology, cell biology, genetics, developmental biology, neurology and epidemiology.

As part of a century-long commitment to understanding host immunity, the Department has taken the lead in training the future generations of immunologists. Notably, members of the department organize what is considered the top Immunology Masters course in France, attracting students from all over the world, who benefit from lectures in fundamental and applied immunology. Research Units within the department also welcome masters, graduate and post-doctoral students. Currently there are 34 students, at different stages of their training.

The Department of Immunology would like to thank its generous sponsors, whose support enables to maintain a robust academic environment within the department.



“Disruptive Discoveries for HIV, HCV and HBV Infections” by Raymond Schinazi – Virology & Immunology departments joint seminar

Building: Centre François Jacob – Room: Auditorium Centre François Jacob – Address: 28 Rue du Docteur Roux, Paris, France
2018-04-23 17:30:00 2018-04-23 18:30:00 Europe/Paris “Disruptive Discoveries for HIV, HCV and HBV Infections” by Raymond Schinazi – Virology & Immunology departments joint seminar VIROLOGY AND IMMUNOLOGY DEPARTMENTS  JOINT SEMINAR Raymond SCHINAZI  Frances Winship Walters Professor, Emory University  “Disruptive Discoveries for HIV, HCV and HBV Infections” Monday April 23rd, at 5:30 pm Auditorium Centre François Jacob   Invited […] 28 Rue du Docteur Roux, Paris, France

Seminar by Thomas Wynn, Head of the Early Discovery, Inflammation and Immunology unit, Pfizer Worldwide R&D

Building: Monod – Room: Amphi Monod – Address: 25 Rue du Docteur Roux, Paris, France
2018-05-16 11:00:00 2018-05-16 00:00:00 Europe/Paris Seminar by Thomas Wynn, Head of the Early Discovery, Inflammation and Immunology unit, Pfizer Worldwide R&D “Type II immunity in tissue repair, regeneration and fibrosis” 25 Rue du Docteur Roux, Paris, France

Modeling the Mammalian Microbiota Host Superorganism – www.mam-2018.org

Building: Centre d'Information Scientifique – Room: Main Auditorium – Address: Institut Pasteur, Paris, France
2018-10-15 09:00:00 2018-10-16 19:00:00 Europe/Paris Modeling the Mammalian Microbiota Host Superorganism – www.mam-2018.org It is now well recognized that the microbiota plays an important role in the development, immunity and physiology of its mammalian host. Considerable progress has been made in identifying microbes and microbial metabolites that […] Institut Pasteur, Paris, France




Department direction
Gérard Eberl: Department director
Ana Cumano: Deputy director for human affairs
Pierre Bruhns: Deputy director for technological affairs
Nathalie Zemmour: Department secretary

Chercheurs A
Titulaire :
Suppléante :
Frédérique MICHEL

Chercheurs B
Titulaire :
Elisabetta BIANCHI
Suppléante :
Friederike JONSSON

Chercheurs post-doctorants
Titulaires :
Cécile ALANIO et
Suppléant :

Titulaires :
Jérémy Postat
Suppléant :

Titulaires :
Hélène SAKLANI et
Suppléante :

Titulaire :
Suppléante :
Béatrice CORRE

Titulaire :
Bérengère HUGOT
Suppléante :
Marie-Laure GOUPIL

Lab Heads

Stanislas Pol
CRT Executive

Andres Alcover
Conseil Scientifique
Immunology course
Assemblée des 100
Pasteur-Weizmann council

Philippe Bousso
Pasteur-Weizmann council
ITMO IHP Scientific advisor 
BioSPC administrative council

 Pierre Bruhns
COMESP (-2015)

Counsellor to Scientific Director

Ana Cumano
Cytometry, Scientific Coordinator
Immunology course

Caroline Demangel

Seminars and WIPs COMESP Direction BioSPC Immunology Board


Ludovic Deriano


MAASCC coordination

 James Di Santo
Adjoint Director Scientific, CRT
 Scientifique Council (-2017)
Gérard Eberl
GPF Microbes & Brain Board
Gnotobiology, Scientific Coordinator

Claude Leclerc
GPF Vaccinology Board
Canceropôle Ile de France

Hugo Mouquet
MAASCC coordination
CRT Executive committee

Lucie Peduto

GPF cancer

Infection & Metabolism Board

Sandra Pellegrini
Equipment for department (public, private)
Erasmus students coordination

Lars Rogge
CRT Steering committee




Elisabetta Bianchi
Erasmus students coordination
COMESP (suppléante)

Béatrice Bréart

Susanna Celli
PPU Dean

Gilles Dadaglio

Darragh Duffy
LabEx Milieu Intérieur, Scientific manager

François Huetz
COMESP (Sous-commission 3)
SFI administrative council

Milena Hasan
CIH, Director

Molly Ingersoll
PPU board
Immunology course

PPU oral presentations course

Friederike Jönsson
Immunology course

Hélène Saklani
Assemblée des 100
COMESP (Sous-commission 3)

Hélène Strick Marchand
Comité utilisateurs A3
COMESP (Sous-commission 3)

Paulo Vieira
Assemblée des 100
PPU Board
COMESP (Sous-commission 3)

Christian Vosshenrich
Immunology course


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