The Comparative Functional Genomics G5 group investigates how evolutionary innovations arise in vertebrate genomes through changes in gene sequences, gene expression and gene regulation. Our main model is the evolution of menstruation, a reproductive trait which was acquired during the evolution of primates, which we investigate by comparing primate uterus samples with a combination of single-cell functional assays and computational analysis. We also develop bioinformatics models and frameworks to study how gene expression and regulation changes through time, and cellular models to test how evolutionary changes in gene function result in measurable molecular phenotypes.
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Featured publications
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2022Classification of non-coding variants with high pathogenic impact., PLoS Genet 2022 04; 18(4): e1010191.
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2021The bowfin genome illuminates the developmental evolution of ray-finned fishes., Nat Genet 2021 09; 53(9): 1373-1384.
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2021A community-led initiative for training in reproducible research., Elife 2021 06; 10(): .
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2021Creating clear and informative image-based figures for scientific publications., PLoS Biol 2021 03; 19(3): e3001161.
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2020Synteny-Guided Resolution of Gene Trees Clarifies the Functional Impact of Whole-Genome Duplications., Mol Biol Evol 2020 11; 37(11): 3324-3337.
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2019Adaptation of Proteins to the Cold in Antarctic Fish: A Role for Methionine?, Genome Biol Evol 2019 01; 11(1): 220-231.
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2018Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression., Nat Ecol Evol 2018 Jan; 2(1): 152-163.
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2015The 3D organization of chromatin explains evolutionary fragile genomic regions., Cell Rep 2015 Mar; 10(11): 1913-24.
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2015Enhancer evolution across 20 mammalian species., Cell 2015 Jan; 160(3): 554-66.
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