ERC 2017-Advanced Grant ENLIGTHEN
To fight cancer or infections, a variety of immune cells are engaged in a tremendously complex, yet highly coordinated sequence of cellular processes. This coordination is enforced by distinct mechanisms of cellular communication allowing […]
Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
The immune system is made up of specialized cells and tissues that act together to fight microbial infections and survey the body for malignant transformation. Immune responses are highly orchestrated and dynamic events that […]
Lymphocyte activation in lymphoid organs
Adaptive immune responses are initiated in secondary lymphoid organs through cellular interactions between antigen-specific T cells and antigen-presenting dendritic cells. One of the aim of our lab is to better understand how T cells […]
Immune responses during infections
Intracellular pathogens have developed strategies to survive in infected cells and reduce their recognition by the innate and adaptive immune systems. Our lab wishes to define the mechanisms influencing the recognition of infected cells […]
Immune responses following transplantation
Transplant rejection involves a coordinated attack of donor cells by the innate and the adaptive immune system of the host. To gain insight into this dynamic process, we have developed an ear skin graft […]
Immune responses against tumors
Cytotoxic T cells and NK cells (CTLs) are key players of anti-tumor immune responses. Despite our fundamental knowledge on the interplay between the immune system and tumor microenvironments, we have a poor understanding on […]
Dynamic In Situ Cytometry
The Dynamic In Situ Cytometry (DISC) is a new approach that combines advantages of both intravital imaging and flow cytometry analysis. With the help of the custom designed DISCit software, the DISC provides the opportunity […]
2023A major role for CD4+ T cells in driving cytokine release syndrome during CAR T cell therapy., Cell Rep Med 2023 Aug; (): 101161.
2023Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity., Nat Cancer 2023 May; (): .
2023Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics., iScience 2023 Feb; 26(2): 106068.
2022Inflammation triggers ILC3 patrolling of the intestinal barrier., Nat Immunol 2022 Aug; (): .
2022SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse., EMBO J 2022 Aug; (): e111528.
2022Spatiotemporal dynamics of calcium signals during neutrophil cluster formation., Proc Natl Acad Sci U S A 2022 Jul; 119(29): e2203855119.
2022High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing., Nat Commun 2022 Jun; 13(1): 3111.
2021Quorum sensing governs collective dendritic cell activation in vivo., EMBO J 2021 Jun; (): e107176.
2021Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo., EMBO J 2021 Apr; (): e106658.
2021A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity., Sci Immunol 2021 Mar; 6(57): .
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