The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system.

The Milieu Intérieur Project

While the immune system is highly complex and responses are known to vary across individuals and populations, medical practices and public health policies remain based on a single model of patient care and drug development. The Milieu Intérieur project was initiated specifically to address this discrepancy. The primary objective of our work is to establish the boundaries of a “healthy” immune response and define the determinants of immune response variation, integrating the relationship among genetics, epigenetics and the environment.

The specific aims of the Milieu Intérieur project are to:

(i) define the naturally-occurring variability of human immune response,

(ii) assess how this variation is genetically, epigenetically or environmentally controlled,

(iii) understand how this genetic/phenotypic variation may account for differences in susceptibility to infection, therapeutic treatment or vaccine response, and (iv) ascertain the variation and role of the microbiota in regulating immune programs.

The Milieu Intérieur project is supported by the French National Ministry of Research. This program is part of a larger French government’s Invest in the Future economic stimulus plan called Investissement d’Avenir  – Laboratoire d’Excellence (LabEx).

Our dataset

MI Design

The Milieu Intérieur dataset. Click to enlarge.


Data visualization

Visualize the data from our Immunity paper “Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli” Duffy et al Slide4


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