Genomes & Genetics


Didier Mazel

Deputy Director

Micheline Fromont-Racine



The Genomes and Genetics Department was formed in 2006, mainly from the teams of the Structure and Dynamics of Genomes Department led by Bernard Dujon.

The department has a staff of 170, working in 13 research structures, 4 technological platforms housed in the Institut Pasteur Genopole, and 6 associated research groups. The teams explore experimental and informatics approaches to determine the nature of genetic information in organisms of increasing complexity, ranging from bacteria and yeasts to humans.

Teams in the Genomes and Genetics Department work in 4 main areas:

  • Evolutionary genomics
  • The Three R’s (Recombination, Replication and Repair)
  • Functional and regulatory networks
  • Host–pathogen interactions

The teams use the full range of genomic and post-genomic approaches to study the various models that can be bacteria (chiefly tuberculosis bacilli, Streptococci, Vibrio, and Legionella), yeasts (Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Candida albicans) or human models. The different pathogenic and model organisms are studied in depth with the aim of understanding how they live and what determines their pathogenic potential. Yeasts are studied, both for their own sake and as archetypes to facilitate our understanding of human genetics.

The department is also investigating the evolution of infectious agents and the selective pressures they have exerted on human genes over time.

The progress of these different research programs benefits greatly from developments in new sequencing and genotyping techniques which we are closely involved in given our links with the Institut Pasteur Genopole.

The Genomes and Genetics Department is also developing major in silico approaches in biological system modeling and bioinformatics analysis in addition to its own research projects and providing support to the Institut Pasteur’s various research structures in conjunction with the CIB.

The department was led by Antoine Danchin between 2006 and 2009.






“Can we eliminate TB using new molecular tests?”
RUTGERS New Jersey Medical School – USA

Séminaire organisé par le Département Génomes & Génétique – conjoint avec le Département de Microbiologie dans le cadre du Cours « Tuberculosis »

Abstract: Despite considerable advances in molecular diagnosis of TB, there has been scant evidence that new diagnostic tests have affected treatment outcomes. This lecture will discuss some of the causes of this problem and the potential solution offered by a new and much more-sensitive point of care test. The potential impact of advanced diagnostics on driving TB evolution will be discussed and the genomic and biochemical underpinnings of drug resistance driven evolution relevant to TB diagnostics will be explored.

Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod – mardi 31 mai 2016 12:00

Contact: Brigitte GICQUEL (



  • Cnrs-Q

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