Genomes & Genetics

Didier Mazel


The Genomes and Genetics Department was formed in 2006, mainly from the teams of the Structure and Dynamics of Genomes Department led by Bernard Dujon.

The department has a staff of 170, working in 13 research structures, 4 technological platforms housed in the Institut Pasteur Genopole, and 6 associated research groups. The teams explore experimental and informatics approaches to determine the nature of genetic information in organisms of increasing complexity, ranging from bacteria and yeasts to humans.

Teams in the Genomes and Genetics Department work in 4 main areas:

  • Evolutionary genomics
  • The Three R’s (Recombination, Replication and Repair)
  • Functional and regulatory networks
  • Host–pathogen interactions

The teams use the full range of genomic and post-genomic approaches to study the various models that can be bacteria (chiefly tuberculosis bacilli, Streptococci, Vibrio, and Legionella), yeasts (Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Candida albicans) or human models. The different pathogenic and model organisms are studied in depth with the aim of understanding how they live and what determines their pathogenic potential. Yeasts are studied, both for their own sake and as archetypes to facilitate our understanding of human genetics.

The department is also investigating the evolution of infectious agents and the selective pressures they have exerted on human genes over time.

The progress of these different research programs benefits greatly from developments in new sequencing and genotyping techniques which we are closely involved in given our links with the Institut Pasteur Genopole.

The Genomes and Genetics Department is also developing major in silico approaches in biological system modeling and bioinformatics analysis in addition to its own research projects and providing support to the Institut Pasteur’s various research structures in conjunction with the CIB.

The department was led by Antoine Danchin between 2006 and 2009.




“Revisiting the central dogma: impact of RNA errors on phenotypic inheritance and genomic stability”

Christophe HERMAN

Department of Molecular & Human Genetics,
Molecular Virology and Microbiology, Baylor College of Medicine,

Houston – Texas

                                                                                                                                                                                                                                                                                                     Errors in information transfer from DNA to RNA to protein are inevitable. Transcription errors occur at a rate of ~10-5 per residue, over 10,000 times higher than errors in DNA synthesis. Errors in DNA synthesis can produce heritable changes in phenotype due to alteration of protein function. Transcription errors, although transient in nature, can also have phenotypic consequences for the cell, including transient and heritable phenotypic change. The overall goal of our research is to define the origins and the consequences of transcription errors , and study the impact of transcription fidelity on DNA repair.                                                                                     


Salle Jean-Paul Aubert, rdc du bâtiment Fernbach –

jeudi  12 novembre 2015 à  11 H 00

contact Didier


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