I have concentrated my past and current work on three main research topics: (i) the genetic history of human populations with distinct modes of subsistence, (ii) the role of admixture in genetic adaptation, and (iii) the environmental and genetic determinants of human variation in the immune system.
Specifically, I aim to evaluate the impact of a major technological revolution, the transition to agriculture, on the demographic and adaptive history of the human species, using a population genomics approach (Patin et al., PLoS Genet 2009; Patin et al., Nat Commun 2014; Patin et al., Science 2017; Choin*, Mendoza-Revilla*, Arauna* et al., Nature 2021). I also aim to evaluate how recent admixture among humans has affected local adaptation, and how to detect the molecular footprints of natural selection in admixed populations (Patin et al., Science 2017; Laso-Jadart et al., Am J Hum Genet 2017; Cuadros-Espinoza et al., Am J Hum Genet 2022). I finally aim to define the environmental and genetic factors that affect the immune response in the general population, within the frame of the LabEx Milieu Intérieur (www.milieuinterieur.fr), using a quantitative genomics approach (Patin*, Hasan*, Bergstedt*, et al., Nat Immunol 2018; Bergstedt, et al., Nat Commun 2022).
