I have concentrated my past and current work on four main research topics: the genetic history and structure of human populations with distinct modes of subsistence, the human genomics of hepatitis C infection, the evolutionary history of human mutations controlling host response to pathogens, and more recently, the environmental and genetic determinants of the immune response in humans.
The first topic corresponds to my main work in the Human Evolutionary Genetics lab, headed by Lluis Quintana-Murci (CNRS URA3012). My objective is to evaluate the impact of a major technological revolution, the transition to agriculture, on the demographic and adaptive history of the human species, using a population genomics approach (Patin et al., PLoS Genet 2009; Patin et al., Nat Commun 2014). My second topic corresponds mostly to studies conducted during my post-doc, in the Human Genetics of Infectious Diseases, headed by Laurent Abel and Jean-Laurent Casanova (INSERM UMR980). The objective was to identify genes and mutations associated with the natural history of hepatitis C infection by genome-wide association (Patin*, Kutalik* et al., Gastroenterology 2012), and several rare Mendelian immune-deficiencies by homozygosity mapping (Crequer et al., J Clin Invest 2012). In my third topic, I combine evolutionary and epidemiology genomics, an approach I am committed to since the beginning of my career (Louicharoen*, Patin*, et al., Science 2009), in order to answer a number of questions at the frontier between medicine and evolution: which were the past selective pressures imposed by pathogens on humans? Have mutations responsible for human susceptibility to infections been advantaged or disadvantaged in the past? Finally, I concentrate my fourth topic on the defining the environmental and genetic determinants of the immune response in the general human population, within the frame of the LabEx Milieu Intérieur, coordinated by Matthew Albert and Lluis Quintana-Murci (www.milieuinterieur.fr). My objectives are to better describe the natural variation of human response to pathogens, measured by a large number of cellular and molecular phenotypes related to immune response, and identify its main genetic determinants by genome-wide association.