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© Research
Laboratory Junior Group (G5)

Evolutionary genomics of RNA viruses

Department of Virology

Etienne Simon-Loriere

Head
Virus HIV1
Department of Virology

About

The Simon-Loriere Lab has been created in the Virology department of Institut Pasteur on Feb 1st, 2018, to work on RNA virus discovery, emergence, transmission, and evolution. We use viral genomics to study evolutionary processes of RNA viruses, with a focus on arboviruses such as dengue and Zika. Like many others, we are also contributing to the fight against COVID-19.  We combine molecular epidemiology studies thanks to amazing collaborations within the Institut Pasteur International Network and experimental work, both in vitro and in vivo. We work a lot with our great colleagues at the Mouse Genetics laboratory and the French National Reference Center for viruses of respiratory infections.

Projects

Project
Ongoing
4 Members

Evolutionary Mechanisms underlying Yellow fever Resurgence in Africa – ANR JCJC

Etienne Simon-Loriere (PI)

Arthropod-borne viruses (arboviruses) pose a major threat to public health worldwide and are continuously (re-)emerging or spreading to uninfected areas. Recent examples notably include dengue, Chikungunya, yellow fever, and Zika virus disease. In addition […]
Project
Ongoing
5 Members

Humoral immunity & human monoclonal antibodies against SARS-CoV-2

Hugo Mouquet (PI)

The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]
Project
Ongoing
5 Members

Study of immune crosstalk in COVID-19 COVIMUNE

Anavaj Sakuntabhai (PI)

Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2 virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is designed to target […]
Project
Ongoing
9 Members

Host genetic susceptibility to Zika virus

Xavier Montagutelli (PI)

Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]

Transversal Project

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]

Fundings

Featured publications

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Pictures & Media

https://www.pasteur.fr/fr/ebola-3-variants-du-virus-identifies-guinee