Evolutionary genomics of RNA viruses

About

The Simon-Loriere Lab has been created in the Virology department of Institut Pasteur on Feb 1st, 2018, to work on RNA virus discovery, emergence, transmission, and evolution.

We use viral genomics to study evolutionary processes of RNA viruses, with a focus on arboviruses such as dengue and Zika.
We are notably interested in the large spectrum of symptoms severity that can result from a viral infection.
We combine molecular epidemiology studies thanks to amazing collaborations within the Institut Pasteur International Network and experimental work, both in vitro and in vivo.

We still work a lot with our former host unit, the Sakuntabhai lab.

 

 

 

Members

Etienne Simon-Loriere

Head of Structure

Head

Matthieu Prot

Technician

Fabiana Gambaro

PhD Student

Deborah Delaune

PhD Student

Transversal Project

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues. Inception program uses Integrative Biology, Social Science […]

Fundings

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Featured publications

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• 2017
  Simon-Lorière E, Duong V, Tawfik A, Ung S, Ly S, Casadémont I, Prot M, Courtejoie N, Bleakley K, Buchy P, Tarantola A, Dussart P, Cantaert T, Sakuntabhai A, Increased adaptive immune responses and proper feedback regulation protect against clinical dengue, Sci Transl Med 2017 Aug;9(405).
• 2017
  Simon-Loriere E, Faye O, Prot M, Casademont I, Fall G, Fernandez-Garcia MD, Diagne MM, Kipela JM, Fall IS, Holmes EC, Sakuntabhai A, Sall AA, Autochthonous Japanese Encephalitis with Yellow Fever Coinfection in Africa, N. Engl. J. Med. 2017 04;376(15):1483-1485.
• 2016
  Urbanowicz RA, McClure CP, Sakuntabhai A, Sall AA, Kobinger G, Müller MA, Holmes EC, Rey FA, Simon-Loriere E, Ball JK, Human Adaptation of Ebola Virus during the West African Outbreak, Cell 2016 Nov;167(4):1079-1087.e5.
• 2015
  Simon-Loriere E, Faye O, Faye O, Koivogui L, Magassouba N, Keita S, Thiberge JM, Diancourt L, Bouchier C, Vandenbogaert M, Caro V, Fall G, Buchmann JP, Matranga CB, Sabeti PC, Manuguerra JC, Holmes EC, Sall AA, Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic, Nature 2015 Aug;524(7563):102-4.
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Pictures & Media

 

 

 

https://www.pasteur.fr/fr/ebola-3-variants-du-virus-identifies-guinee