The Simon-Loriere Lab has been created in the Virology department of Institut Pasteur on Feb 1st, 2018, to work on RNA virus discovery, emergence, transmission, and evolution. We use viral genomics to study evolutionary processes of RNA viruses, with a focus on arboviruses such as dengue and Zika. Like many others, we are also contributing to the fight against COVID-19. We combine molecular epidemiology studies thanks to amazing collaborations within the Institut Pasteur International Network and experimental work, both in vitro and in vivo. We work a lot with our great colleagues at the Mouse Genetics laboratory and the French National Reference Center for viruses of respiratory infections.
Mouse models for Covid-19
Mice are not naturally susceptible to SARS-CoV-2 due to poor binding of the virus spike to the mouse cellular receptor ACE2. We have developed a mouse-adapted strain of SARS-CoV-2 which efficiently replicates in the […]
Evolutionary Mechanisms underlying Yellow fever Resurgence in Africa – ANR JCJC
Arthropod-borne viruses (arboviruses) pose a major threat to public health worldwide and are continuously (re-)emerging or spreading to uninfected areas. Recent examples notably include dengue, Chikungunya, yellow fever, and Zika virus disease. In addition […]
Humoral immunity & human monoclonal antibodies against SARS-CoV-2
The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]
Study of immune crosstalk in COVID-19 COVIMUNE
Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2 virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is designed to target […]
Host genetic susceptibility to Zika virus
Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]
Emerging Infectious Diseases
Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
2017Increased adaptive immune responses and proper feedback regulation protect against clinical dengue., Sci Transl Med 2017 Aug; 9(405): .
2017Autochthonous Japanese Encephalitis with Yellow Fever Coinfection in Africa., N Engl J Med 2017 04; 376(15): 1483-1485.
2016Human Adaptation of Ebola Virus during the West African Outbreak, Cell 2016 Nov;167(4):1079-1087.e5.
2015Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic, Nature 2015 Aug;524(7563):102-4.
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