10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]
Deciphering Human Innate Lymphoid Cell Biology
ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. Three groups of ILCs […]
Genetic traits involved in the regulation of NK cell and ILC-mediated anti-tumor functions
Rudolf Virchow postulated more than 150 years ago that inflammation might be linked to cancer development. Although a large body of experimental evidence accumulated to date strongly supports such a link, it is less […]
Journée de la recherche translationnelle (JRT)
A full-day mini-symposium dedicated to translational research. This event is organised since 2015 by the Centre de recherche Translationnelle and was organised since 2007 by the former Center for Human Immunology now part of […]
Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
Adult neurogenesis and brain plasticity
The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Mouse Model to Understand Innate Lymphoid Cell Biology
Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
Pathogen co-infection : HIV, TB, Malaria and HCV
Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Host responses to microbial intestinal invasion, impact on microbial dissemination
We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Humanized mouse models for studying viral hepatitis
Hepatitis B virus (HBV), hepatitis C virus (HCV) and Plasmodium falciparum are three major human hepatic pathogens, which together are responsible for more than 500 million infections worldwide and 2.5 to 4.5 million deaths […]
A novel mouse model for conditional gene targeting
Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]
2018Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23, Sci Immunol 2018 Dec;3(30).
2018The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses, PLoS Pathog. 2018 Oct;14(10):e1007406.
2018Peyer’s patch myeloid cells infection by Listeria signals through gp38 stromal cells and locks intestinal villus invasion, J. Exp. Med. 2018 Oct;.
2018ILC-poiesis: Ensuring tissue ILC differentiation at the right place and time, Eur. J. Immunol. 2018 Oct;.
2018Human thymopoiesis is influenced by a common genetic variant within the locus, Sci Transl Med 2018 Sep;10(457).
2018Innate Lymphoid Cells: 10 Years On, Cell 2018 Aug;174(5):1054-1066.
2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines, Genome Med 2018 07;10(1):59.
2018Innate Lymphoid Cell Development: A T Cell Perspective, Immunity 2018 Jun;48(6):1091-1103.
2018A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity, Sci Immunol 2018 Jun;3(24).
2018Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility, J. Allergy Clin. Immunol. 2018 Feb;.
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