9th HKU-Pasteur Immunology Course: March 19-31, 2017
The general theme of this year’s course will be Quantitative Immunology to explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, to a more integrated view […]
Deciphering Human Innate Lymphoid Cell Biology
ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. Three groups of ILCs […]
Genetic traits involved in the regulation of NK cell and ILC-mediated anti-tumor functions
Rudolf Virchow postulated more than 150 years ago that inflammation might be linked to cancer development. Although a large body of experimental evidence accumulated to date strongly supports such a link, it is less […]
Journée de la recherche translationnelle (JRT)
A full-day mini-symposium dedicated to translational research. This event is organised at Institut Pasteur since 2007 by the former Center for Human Immunology and since 2015 by the Centre de recherche Translationnelle. Register for […]
Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
Adult neurogenesis and brain plasticity
The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Mouse Model to Understand Innate Lymphoid Cell Biology
Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
Pathogen co-infection : HIV, TB, Malaria and HCV
Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Host responses to microbial intestinal invasion, impact on microbial dissemination
We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Humanized mouse models for studying viral hepatitis
Hepatitis B virus (HBV), hepatitis C virus (HCV) and Plasmodium falciparum are three major human hepatic pathogens, which together are responsible for more than 500 million infections worldwide and 2.5 to 4.5 million deaths […]
A novel mouse model for conditional gene targeting
Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]
2017Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation, Cell 2017 Mar;168(6):1086-1100.e10.
2017In Vivo Efficacy of Umbilical Cord Blood Stem Cell-Derived NK Cells in the Treatment of Metastatic Colorectal Cancer, Front Immunol 2017;8:87.
2017Glomerular common gamma chain confers B- and T-cell-independent protection against glomerulonephritis, Kidney Int. 2017 Jan;.
2016Immunology’s Twinning Triangle, Eur. J. Immunol. 2016 Oct;46(10):2283-2285.
2016Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells, Mucosal Immunol 2016 Sep;.
2016Interleukin 15-Dependent T Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease, Immunity 2016 Aug;.
2016Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses, Cell Rep 2016 Sep;16(10):2777-91.
2016The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome, Cell 2016 Aug;.
2016Notch signaling in group 3 innate lymphoid cells modulates their plasticity, Sci Signal 2016;9(426):ra45.
2016Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells, J. Immunol. 2016 Jun;196(11):4731-8.
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