10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]
Deciphering Human Innate Lymphoid Cell Biology
ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. Three groups of ILCs […]
Genetic traits involved in the regulation of NK cell and ILC-mediated anti-tumor functions
Rudolf Virchow postulated more than 150 years ago that inflammation might be linked to cancer development. Although a large body of experimental evidence accumulated to date strongly supports such a link, it is less […]
Journée de la recherche translationnelle (JRT)
A full-day mini-symposium dedicated to translational research. This event is organised since 2015 by the Centre de recherche Translationnelle and was organised since 2007 by the former Center for Human Immunology now part of […]
Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Mouse Model to Understand Innate Lymphoid Cell Biology
Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
Pathogen co-infection : HIV, TB, Malaria and HCV
Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Host responses to microbial intestinal invasion, impact on microbial dissemination
We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Humanized mouse models for studying viral hepatitis
Hepatitis B virus (HBV), hepatitis C virus (HCV) and Plasmodium falciparum are three major human hepatic pathogens, which together are responsible for more than 500 million infections worldwide and 2.5 to 4.5 million deaths […]
A novel mouse model for conditional gene targeting
Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]
2020Antibody-coated microbiota in nasopharynx of healthy individuals and hypogammaglobulinemia patients, J. Allergy Clin. Immunol. 2020 Jan;.
2019Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses and in Humanized Mice, Antimicrob. Agents Chemother. 2019 Nov;.
2019Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition), Eur. J. Immunol. 2019 Oct;49(10):1457-1973.
2019A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals, Microbiome 2019 Sep;7(1):130.
2019Exhaustion and senescence marker profiles on human T cells in BRGSF-A2 humanized mice resemble those in human samples, J. Leukoc. Biol. 2019 Aug;.
2019An Id2-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials, Immunity 2019 Apr;50(4):1054-1068.e3.
2019Accelerated thymopoiesis and improved T cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice, Eur. J. Immunol. 2019 Mar;.
2019Modeling Infectious Diseases in Mice with a “Humanized” Immune System, Microbiol Spectr 2019 03;7(2).
2019Editorial overview: Pillars of innate immunity: constantly learning and trying to remember, Curr. Opin. Immunol. 2019 Feb;56:iii-vi.
2018Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23, Sci Immunol 2018 Dec;3(30).
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