10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. https://www.youtube.com/watch?v=IXlKElDJMc8 The Milieu Intérieur Project While the […]
Modeling SARS-CoV-2 infection and immune responses in humanized mouse models
Deciphering the causes of Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Immune profiling to guide host-directed interventions to cure HBV
The overall aim of the project is to investigate the immune responses to HBV and develop novel treatment concepts to cure chronic HBV. HBV is a major global health problem with over 257 million […]
Deciphering Human Innate Lymphoid Cell Biology
ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. Three groups of ILCs […]
Genetic traits involved in the regulation of NK cell and ILC-mediated anti-tumor functions
Rudolf Virchow postulated more than 150 years ago that inflammation might be linked to cancer development. Although a large body of experimental evidence accumulated to date strongly supports such a link, it is less […]
Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Mouse Model to Understand Innate Lymphoid Cell Biology
Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
Pathogen co-infection : HIV, TB, Malaria and HCV
Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Host responses to microbial intestinal invasion, impact on microbial dissemination
We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Humanized mouse models for studying viral hepatitis
Hepatitis B virus (HBV), hepatitis C virus (HCV) and Plasmodium falciparum are three major human hepatic pathogens, which together are responsible for more than 500 million infections worldwide and 2.5 to 4.5 million deaths […]
A novel mouse model for conditional gene targeting
Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]
2022Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller., J Exp Med 2022 Mar; 219(3): .
2022Trained ILC3 responses promote intestinal defense., Science 2022 Feb; 375(6583): 859-863.
2022Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC transplanted SCID patients with IL2RG/JAK3 deficiency., Blood 2022 02; (): .
2022CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages., J Exp Med 2022 Feb; 219(2):e20210987.
2022Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein., J Biol Chem 2022 01; 298(1): 101290.
2021Our latest edition of Flow Cytometry Guidelines for basic and clinical immunologists!, Eur J Immunol 2021 12; 51(12): 2703.
2021Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)., Eur J Immunol 2021 12; 51(12): 2708-3145.
2021Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study., EBioMedicine 2021 Nov; 73(): 103637.
2021A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters., Nat Commun 2021 11; 12(1): 6277.
2021Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis., Cell Rep 2021 10; 37(4): 109887.
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