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© William Beaucardet
Reportage Unité Intéractions bactéries cellules
Publication : Clinical immunology (Orlando, Fla.)

The Milieu Intérieur study – an integrative approach for study of human immunological variance

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Clinical immunology (Orlando, Fla.) - 03 Jan 2015

Thomas S, Rouilly V, Patin E, Alanio C, Dubois A, Delval C, Marquier LG, Fauchoux N, Sayegrih S, Vray M, Duffy D, Quintana-Murci L, Albert ML,

Link to Pubmed [PMID] – 25562703

Clin. Immunol. 2015 Apr;157(2):277-93

The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. Herein, we define the criteria utilized for participant enrollment, and highlight the key data that were collected for correlative studies. In this report, we analyzed biological correlates of sex, age, smoking-habits, metabolic score and CMV infection. We characterized and identified unique risk factors among healthy donors, as compared to studies that have focused on the general population or disease cohorts. Finally, we highlight sex-bias in the thresholds used for metabolic score determination and recommend a deeper examination of current guidelines. In sum, our clinical design, standardized sample collection strategies, and epidemiological data analyses have established the foundation for defining variability within human immune responses.

https://www.ncbi.nlm.nih.gov/pubmed/25562703