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About

Dr. Natalia Pietrosemoli is an Engineer with a M. Sc. in Modeling and Simulation of Complex Realities from the International Center for Theoretical Physics, ICTP and the International School of Advanced Studies, SISSA (Triest, Italy). During her M. Sc. internships she mostly worked in modeling, optimization, combinatorics and information theory applied to medical imaging.

In 2012 she got a Ph. D in Computational Biology from the School of Bioengineering of Rice University (Houston, TX, US), where she specialized in computational structural biology and functional genomics. Her doctoral thesis “Protein functional features extracted with from primary sequences : a focus on disordered regions”, contributed to a better understanding of the functional and evolutionary role of intrinsic disorder in protein plasticity, complexity and adaptation to stress conditions.

As part of her Ph. D.,  Natalia was a visiting scholar in two labs in Madrid:  the Structural Computational Biology Group at the Spanish National Cancer Research Centre (CNIO), where she mainly worked in sequence analysis and the functional-structural relationships of proteins, and the Computational Systems Biology Group at the Spanish National Centre for Biotechnology (CNB-CSIC ), where she studied the functional implications of intrinsically disordered proteins at the genomic level for several organisms, collaborating with different experimental and theoretical groups.

In 2013,  she joined the Swiss Institute of Bioinformatics as a postdoctoral fellow in the Bioinformactics Core Facility. Her main project consisted in the molecular classification of a rare type of lymphoma, which involved the integration of transcriptomic, clinical and mutational data for the identification of molecular markers for classification, diagnosis and prognosis. This work was performed in collaboration with the Pathology Institute at the University Hospital of Lausanne (CHUV).

In November of 2015 Natalia joined the Hub Team @ Pasteur C3BI as a Senior Bioinformatician.   Natalia is especially interested in the integrative analysis of different omics data, both at large-scale and for small datasets, and loves collaborating in interdisciplinary environments and having feedback from her fellow experimental colleagues.

Currently, she’s coordinating several projects performing functional and pathway analysis at the genomic level. By grouping genes, proteins and other biological molecules into the pathways they are involved in, the complexity of the analyses is significantly reduced, while the explanatory power increases with respect to having a list of differentially expressed genes or proteins.

Courses

Training: analysis of the transcriptome by RNAseq

The Transcriptome and Epigenome platform of the Biomics pole is organizing a one week (October 10, 2016 – October 14, 2016) training session dedicated to the analysis of the transcriptome by RNAseq. It  is […]

2016-10-10 09:00:00 2016-10-14 17:00:00 Europe/Paris Training: analysis of the transcriptome by RNAseq The Transcriptome and Epigenome platform of the Biomics pole is organizing a one week (October 10, 2016 – October 14, 2016) training session dedicated to the analysis of the transcriptome by RNAseq. It  is […] 28 Rue du Docteur Roux, Paris, France

CV

Senior Bioinformatician

November 2015– Present. Institut Pasteur, Paris

PostDoc fellow

October 2013 – October 2015. Swiss Institute of Bioinformatics. Bioinformatics Core Facility (BCF). Lausanne, Switzerland.

Phd fellow

September 2006 – December 2012. School of Bioengineering. Rice University. Computational Biology.

Visiting Scholar

January 2011 – May 2013. National Centre for Biotechnology (CNB-CSIC). Computational Systems Biology Group. Universidad Autónoma, Madrid, Spain.

Visiting Scholar

September 2009 – December 2010. Spanish National Cancer Centre. Structural Biology and Biocomputing Programme, Madrid, Spain.

Magister of Science

September 2001 – September 2003. Modeling and Simulation of Complex Realities. Joint Programme of the International Center for Theoretical Physics, ICTP and the International School of Advanced Studies, SISSA in Triest, Italy.

Publications

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