After graduating from Paris VI University with a PhD in Genetics on the “Role of histone protein post-translational modifications in splicing regulation” that I performed in the Epigenetic Regulation unit at the Institut Pasteur, I carried out two post-doctoral experiences.
I first worked for three years as a postdoctoral associate of the Whitehead Institute for Biomedical Research/MIT in Cambridge (USA). My main project consisted in designing a method and developing a bioinformatic program, named CRCmapper, to predict the transcription factors that are at the core of the regulation of gene expression programs. Using enhancer information and integrating genomic, epigenomic and transcriptomic data, CRCmapper is able to predict the Core transcriptional Regulatory Circuitry (CRC) of any human or mouse cell sample. This work led to propose maps of transcriptional regulatory networks for 75 human cell and tissue types and the method is now patented.
I then worked for two years at Institut Curie, where I identified coding and non-coding transcriptional signatures allowing to distinguish stable sub-populations of plasmocytoid predendritic innate immune cells upon diversification triggered by a single immune stimulation. These signatures enabled identification of upstream control of this regulation by a TNF communication loop.
In 2018, I joined the HUB of the Institut Pasteur Computational Biology Department. Since then, I am detached to work with the Translational Immunology Lab on the “Milieu Intérieur” Project. In particular, I am performing multivariate data analyses and high-throughput data integrations to better understand human immune response determinants and contribute to precision medicine development.
In parallel, I have set up or contribute to the following courses:
– “ChIP-seq data analysis” (1 day per session), in Bioinformatics program for PhD students “Bioinformatics”, Institut Pasteur, Paris, since 2019
– “Multivariate Data Analysis” (2 days per session), in Bioinformatics program for PhD students “R Programming and Statistics”, Institut Pasteur, Paris, since 2018
– “IA et Santé” course (one-week), Centrale-Supelec, Paris, since 2019
– Invited lectures, Ecole Centrale de Nantes, since 2019
I am also regularly training students and participated in the following conference organization or evaluation committees:
– Member of the organization committee of JOBIM 2021
– Invited member for oral and poster evaluation at the YRLS conference, Paris 2019 and 2023
– Jury member for Societé Française de Bioinformatique (SFBI) poster price, JOBIM 2019