After a PhD in bioinformatics and microbial ecology, I joined the team of C. Brochier-Armanet (Laboratoire de Biométrie et Biologie Évolutive) for a 2 years postdoc to study the deep evolution history of Archaea and Bacteria. Then I performed a postdoc at Institut Pasteur in S Gribaldo’s team to develop phylogenomic approaches aiming at tackling ancient evolutionary events within the microbial world. Since January 2018, I integrated the HUB as a permanent bioinformatician and I am involved in phylogenomic, metagenomics and comparative genomics projects.
Introduction to Molecular Phylogenetics – ENS Paris
Introduction to Molecular Phylogenetics course aims to give the basic theoretical and practical concepts, best practices, and software necessary to start working on molecular phylogenetics and its applications to epidemiology. The course will have […]
Introduction à la Phylogénie Moléculaire : Concepts, méthodes et interprétation
Ce cours a pour objectif de donner les bases théoriques et pratiques, ainsi que les bonnes pratiques nécessaires au démarrage de travaux en phylogénie et épidémiologie moléculaires. Les sessions théoriques donneront les bases du […]
The outer membrane (OM) is an essential element in Gram-negative (diderm) bacteria. Its integrity is maintained by the control of lipids asymmetry via LPS and phospholipids transport by the Lpt and Mla systems, respectively. […]
ANR-METHEVOL: Characterization of new players and evolutionary transitions in the methane metabolism, a backbone in the evolution of the archaeal domain
Methanogenesis is an archaeal-specific metabolism that could have been active as early as 3.5 Gy ago with a direct impact on the evolution of the Earth’s climate system, as well as on current global […]
ANR-VIROMET-Uncovering the VIRome of archaeal METhanogens
Methanogenic archaea are phylogenetically diverse, ancient and environmentally widespread. They are common inhabitants of the gastrointestinal tract of humans and other animals, and produce methane, a potent green-house gas, as a metabolic by-product. Despite […]
ANR Fir-OM: Firmicutes with an outer membrane: toward new models to study the diderm/monoderm cell envelope transition
The bacterial envelope is one of the oldest and most essential cellular components, being involved in key housekeeping functions, such as physical integrity, cell division, motility, substrate uptake and secretion, and cell-cell communication. It […]
PTR OmNega: A multi-disciplinary investigation of the Negativicutes: atypical Firmicutes with LPS-outer membranes that inhabit the human gut
The Negativicutes are a poorly studied lineage of bacteria that include common inhabitants of the human oral and gut microbiome such as the anaerobe Veillonella, and which can also develop into opportunistic pathogens. Despite […]
Institut Pasteur (EBMC Unit – Bioinformatics and Biostatistics HUB)2017Postdoctoral fellow (9 months)
Institut Pasteur (BMGE Unit)2015Postdoctoral fellow (2 years)
Laboratoire de Biométrie et Biologie Évolutive, Université Lyon 12013Postdoctoral fellow (1,5 years)
Laboratoire Microorganismes : Génome et Environnement, Université Clermont
2013Phd in Bioinformatics at Université Blaise Pascal, Clermont-Ferrand
Exploring the microbial diversity from high throughput sequencing2009Master 2 research at Université Blaise Pascal, Clermont-Ferrand
Analysis and modelling of biological data2007Diploma in Agronomic engineering from Institut Agronomique et Vétérinaire Hassan II
Rabat – Morocco
2021Comparative genomic analysis of Methanimicrococcus blatticola provides insights into host adaptation in archaea and the evolution of methanogenesis, Thomas, C.M., Taib, N., Gribaldo, S. et al. Comparative genomic analysis of Methanimicrococcus blatticola provides insights into host adaptation in archaea and the evolution of methanogenesis. ISME COMMUN. 1, 47 (2021)..
2021A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes., Science 2021 04; 372(6541): 516-520.
2021Single-Stranded DNA-Binding Proteins in the Archaea., Methods Mol Biol 2021 ; 2281(): 23-47.
2020A dynamic, ring-forming MucB / RseB-like protein influences spore shape in Bacillus subtilis., PLoS Genet 2020 12; 16(12): e1009246.
2020Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition., Nat Ecol Evol 2020 Oct 19. Online ahead of print.
2020Autotransporters drive biofilm formation and auto-aggregation in the diderm Firmicute Veillonella parvula, J Bacteriol . 2020 Aug 17;JB.00461-20. doi: 10.1128/JB.00461-20. Online ahead of print. .
2020One or two membranes? Diderm Firmicutes challenge the Gram-positive/Gram-negative divide., Mol. Microbiol. 2020 03; 113(3): 659-671.
2020Transient Dynamics of Archaea and Bacteria in Sediments and Brine Across a Salinity Gradient in a Solar Saltern of Goa, India., Front Microbiol 2020 ; 11(): 1891.
2019The phytopathogenic nature of Dickeya aquatica 174/2 and the dynamic early evolution of Dickeya pathogenicity, Environ. Microbiol. 2019 Aug;21(8):2809-2835.
2019Comparative genomics and proteogenomics highlight key molecular players involved in Frankia sporulation, Res. Microbiol. 2019 Jun - Aug;170(4-5):202-213.
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