After a diploma of statistician engineer from the Ensai (Ecole Nationale de la Statistique et de l’Analyse de l’Information) and a Ph.D in applied mathematics in the Statistics & Genome lab (AgroParisTech), I worked as a developer for the XLSTAT software. I have implemented some statistical methods such as mixture models, log-linear regression, mood test, bayesian hierarchical modeling CBC/HB, … Then I worked as a head teacher in statistics for one year. I was recruited in the Bioinformatic and biostatistic hub of the C3BI (Center of Bioinformatics, Biostatistics and Integrative Biology) in 2014, I am in charge of the statistical analysis and the development of R/R shiny pipelines.
Courses
Multiple roles of RNAs
A practical course on RNA methods RNA research is at the basis of our current understanding of gene expression regulation and was crucial for the discovery of tools such as siRNA and CRISPR/Cas9. RNA […]
Bioinformatics program for PhD students 2020-2021
This mandatory training program, required for all Institut Pasteur PhD students, begins with a group of common core courses including a knowledge base in reproducible research, R Programming and Statistics. Each student then can […]
Introduction to data analysis
This five weeks graduate level course will give participants basic skills and hands-on training in biostatistics. It will cover all the steps of an analysis workflow : design, collection, curation, hypothesis testing and data […]
Morning session – Data analysis using R
This course is an introduction to data analysis. It is better to have a minimal knowledge of R. If not, an introductory tutorial is available on the course’s web page and the basics of […]
Introduction to Data Analysis
This four-week graduate level course will give participants basic skills and hands-on training in statistics and descriptive data analysis. This course is (primarily) dedicated to first year PhD students of the Institut Pasteur (each […]
Introduction to Data Analysis
This four-week graduate level course will give participants basic skills and hands-on training in statistics and descriptive data analysis. This course is (primarily) dedicated to first year PhD students of the Institut Pasteur (each […]
Introduction to Data Analysis
This four-week graduate level course will give participants basic skills and hands-on training in statistics and descriptive data analysis. This course is (primarily) dedicated to first year PhD students of the Institut Pasteur (each […]
Projects
Software
CV
Professional Experience
Since October 2014 – Institut Pasteur – HUB Team
2013 – 2014 – Head teacher in statistics – MEDISUP sciences
Main activities: Teach statistics to first year medicine students
2012 – 2013 – Developer of algorithms and statistical methods – Addinsoft, XLSTAT software
Main activities: Implement new statistical modules for XLSTAT software. Write support and tutorials for each new methods (french/english).
2008 – 2012 – Ph.D student in applied mathematics, statistics – AgroParisTech
Subject: Semi-parametric modelisation with Markovian dependency. Main activities: Develop new statistical models to deal with spatial dependency in tiling-array data (microarrays with overlapping probes). Supervisors: Stéphane Robin and Marie-Laure Martin Magniette
Education
2012 – Ph.D in applied mathematics, statistics – AgroParisTech
2008 – Master 2 degree in mathematics, statistics option – Université de Rennes 1
2008 – Biostatistics engineer – ENSAI (Ecole Nationale de la Statistique et de l’Analyse de l’Information) – Bruz
Publications
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2022Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry., Nat Commun 2022 Jan; 13(1): 521.
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2021Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection., ISME J 2021 03; 15(3): 702-719.
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2021Optimal combination of early biomarkers for infection and sepsis diagnosis in the emergency department: The BIPS study., J Infect 2021 Feb; (): .
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2020SHAMAN: a user-friendly website for metataxonomic analysis from raw reads to statistical analysis., BMC Bioinformatics 2020 Aug; 21(1): 345.
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2020Antiapoptotic Clone 11-Derived Peptides Induce In Vitro Death of CD4+ T Cells Susceptible to HIV-1 Infection., J Virol 2020 07; 94(14): .
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2020Allostatic load, emotional hyper-reactivity, and functioning in individuals with bipolar disorder, Bipolar Disord 2020 May;.
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2020Leucine-Rich Immune Factor APL1 Is Associated With Specific Modulation of Enteric Microbiome Taxa in the Asian Malaria Mosquito, Front Microbiol 2020;11:306.
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2019Ubiquitination of Listeria Virulence Factor InlC Contributes to the Host Response to Infection., mBio 2019 12; 10(6): .
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2019Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype., PLoS Pathog 2019 07; 15(7): e1007945.
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2019Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection., Nat Metab 2019 07; 1(7): 704-716.
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