I have over twenty years’ experience as a bioinformatics research engineer in both academic and industrial environments. I have a master’s degree in biomathematics from the Université Denis Diderot (Paris 7, France). I gained solid experience working for two biotech companies (Genset and MCL – Molecular Cytogenetic Labs) over a period of ten years. During this time, I developed tools for analysing genomic data to study human diseases, and customised a chip for diagnosing neurological pathologies (CGH array). I joined the Institut Pasteur’s proteomics platform in 2007. I was responsible for all aspects of bioinformatics applied to mass spectrometry-based proteomics, from data generation to analysis. In 2018, I joined the Environment and Infectious Risks research unit headed by Jean Claude Manuguerra to work on the development and implementation of solutions for the identification and characterisation of pathogens from clinical, animal or environmental samples. I have acquired solid expertise in project management and monitoring, as well as in the analysis and interpretation of ‘omics‘ data.
PHINDaccess – Comparative Genomics
Comparative genomics is a field of biological research in which a variety of tools are used to compare genome sequences of different species. By carefully comparing characteristics that define various organisms, researchers can pinpoint […]
Bioinformatics program for PhD students 2020-2021
This mandatory training program, required for all Institut Pasteur PhD students, begins with a group of common core courses including a knowledge base in reproducible research, R Programming and Statistics. Each student then can […]
Évaluation de l’état sanitaire des populations de rats et autres petits mammifères
Sorry, this entry is only available in French.
Pôle de Génotypage des Pathogènes (PGP)
The Genotyping of Pathogens Pole, the centre for microbial genomics of the Environment and Infectious Risks Research and Expertise Unit, provides skills with genotyping and genomics technologies for the characterization of sensitive pathogens and/or […]
CyaA secretion, folding and translocation across membrane
CyaA, a 1706 residue-long protein, is one of the major virulence factors produced by B. pertussis and plays an important role in the early stages of respiratory tract colonization. This toxin uses an original […]
Development of a new statistical tool for the analysis of large HDX-MS data sets
Hydrogen Deuterium eXchange followed by Mass Spectrometry (HDX-MS) is a recognized biophysical tool in structural biology capable of probing protein/ligand interactions, conformational changes, and protein folding and dynamics. The use of improved HDX-MS workflows […]
Post translational modifications (PTM)
Post translational modifications (PTMs) are known to play pivotal roles in cellular physiology and disease, but only a few of the over 300 currently known modifications are extensively investigated in proteomic studies. The most […]
Affinity Purification Mass Spectrometry (AP-MS) is the method of choice to study protein-protein interactions (PPI) and complexes under near physiological conditions. A protein of interest – the bait – is purified by either a […]
MEMHDX – Mixed Effects Models for HDX experiments
This tool allows users to perform an automated workflow to analyze, validate and visualize large HDX-MS datasets. The input file is the output of DynamX software from Waters. Output files provide a plot of […]
2023Complete Genome Sequences of Monkeypox Virus from a French Clinical Sample and the Corresponding Isolated Strain, Obtained Using Nanopore Sequencing., Microbiology Resource Announcements, 2023, 12 (4), pp.e0000923. ⟨10.1128/mra.00009-23⟩.
2021Whole genome sequencing and phylogenetic analysis of six SARS-CoV-2 strains isolated during COVID-19 pandemic in Tunisia, North Africa., BMC Genomics 2021 Jul; 22(1): 540.
2021Genomic characterization and phylogenetic analysis of the first SARS-CoV-2 variants introduced in Lebanon., PeerJ 2021 ; 9(): e11015.
2021No evidence for a pathogen associated with pulmonary MALT lymphoma: a metagenomics investigation., Infect Agent Cancer 2021 Feb; 16(1): 10.
2021No evidence for a pathogen associated with pulmonary MALT lymphoma: a metagenomics investigation, Infectious Agents and Cancer, 2021, 16 (1), ⟨10.1186/s13027-021-00351-w⟩.
2020First detection and genome sequencing of SARS-CoV-2 in an infected cat in France., Transbound Emerg Dis 2020 Nov; 67(6): 2324-2328.
2020Shigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escape., PLoS Pathog 2020 Aug; 16(8): e1008822.
2020Hydrogen/Deuterium Exchange Mass Spectrometry for the Structural Analysis of Detergent-Solubilized Membrane Proteins., Methods Mol Biol 2020 ; 2127(): 339-358.
2020Comparison of a human neuronal model proteome upon Japanese encephalitis or West Nile Virus infection and potential role of mosquito saliva in neuropathogenesis., PLoS One 2020 ; 15(5): e0232585.
2020Rapid Genomic Characterization of SARS-CoV-2 by Direct Amplicon-Based Sequencing Through Comparison of MinION and Illumina iSeq100TM System., Front Microbiol 2020 ; 11(): 571328.
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