Fungal infections can disseminate and become life-threatening if they are not effectively treated. Limited available antifungal drugs combined with drug resistance and drug tolerance can further complicate their treatment. Our work is focused on understanding how Candida cells respond and adapt to antifungal drugs. In particular, we study how individual differences between cells can allow fungal populations to escape drug inhibition. Antifungal tolerance and heteroresistance have been recently described in fungi and we seek to understand the mechanisms enabling these phenomena. To address these questions, we combine tools in molecular biology, genomics, transcriptomics, and animal models of infections.
Interested in working with us? We are looking for motivated students and postdocs to join our team.