The project of the Unit RNA Biology of Fungal Pathogens deals with the study of the structure and plasticity of the transcriptomes of human fungal pathogens. We are mainly using the basidiomycete yeast Cryptococcus neoformans as model, but we are also considering additional pathogenic or non-pathogenic fungi for comparison. We are mainly interested in three dynamic features of the transcriptome: the introns, the UTRs, and the lncRNAs. Part of the project will use global approaches and diverse omics technologies to create an exhaustive list of all the mRNA and lncRNA molecules in the cells in order to study their differential expression in response to environmental cues. We are also using the strength of yeast genetics to decipher the mechanisms regulating the diversity of these features and the level of gene expression in response to these signals. These basic results are of course applied toward more virulence-oriented questions in studying how the transcriptome structure is regulated during infection and the consequences of these modifications for the fungus and host.
Click to view graph
Connections
Members
Former Members
2000
2000
Name
Position
2015
2020
Floriane Pax
Undergraduate Student
2015
2020
Elise Iracane
2015
2020
Rafael Bastos
PhD Student
2015
2020
Liza Dermel
Graduate Student
2015
2020
Patricia A.G. Ferrareze
PhD Student
2015
2020
Corinne Baran
Administrative Staff
2015
2020
Ophélie Lautier
Undergraduate Student
2015
2020
Thomas Damagnez
Graduate Student
2015
2020
Luciana De Oliveira
Post-doc
2019
2022
Juliana Rizzo Balancin
Post-doc
Projects
Transversal Project
Equipments

FastPrep • MP • 24- 5G
Broyage de petits volumes de cellules Contact : Frédérique Moyrand (fmoyrand@pasteur.fr or tel:8436 /8311) Location : Fernbach-68-04-13
Fundings
Publications
Download-
2023Conidium Specific Polysaccharides in Aspergillus fumigatus., J Fungi (Basel) 2023 Jan; 9(2): .
-
2022Alternative Transcription Start Site Usage and Functional Implications in Pathogenic Fungi., J Fungi (Basel) 2022 Oct; 8(10): .
-
2022The role of glycosylphosphatidylinositol (gpi) anchored proteins in Cryptococcusneoformans., Microbes Infect 2022 ; 24(8): 105016.
-
2021Host cell membrane microdomains and fungal infection., Cell Microbiol 2021 Aug; (): e13385.
-
2021Cryptococcus extracellular vesicles properties and their use as vaccine platforms., J Extracell Vesicles 2021 08; 10(10): e12129.
-
2021Insights in the molecular mechanisms of an azole stress adapted laboratory-generated Aspergillus fumigatus strain., Med Mycol 2021 Jul; 59(8): 763-772.
-
2021Structure, composition and biological properties of fungal extracellular vesicles, microLife, Volume 2, 2021, uqab009.
-
2021Commensalism instead of sex? Adapting mating to live in the gut., Cell Host Microbe 2021 06; 29(6): 856-858.
-
2021Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution., G3 (Bethesda) 2021 Apr; (): .
-
2021Application of an optimized annotation pipeline to the Cryptococcus deuterogattii genome reveals dynamic primary metabolic gene clusters and genomic impact of RNAi loss., G3 (Bethesda) 2021 Feb; 11(2): .
-
+View full list of publications
Contact
Phone: 33 1 45 68 83 56 Email: janbon@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France