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  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
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  • Director of Center
  • Director of Department
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© Institut Pasteur
Cryptococcus neoformans

About

The project of the Unit RNA Biology of Fungal Pathogens deals with the study of the structure and plasticity of the transcriptomes of human fungal pathogens. We are mainly using the basidiomycete yeast Cryptococcus neoformans as model, but we are also considering additional pathogenic or non-pathogenic fungi for comparison. We are mainly interested in three dynamic features of the transcriptome: the introns, the UTRs, and the lncRNAs. Part of the project will use global approaches and diverse omics technologies to create an exhaustive list of all the mRNA and lncRNA molecules in the cells in order to study their differential expression in response to environmental cues. We are also using the strength of yeast genetics to decipher the mechanisms regulating the diversity of these features and the level of gene expression in response to these signals. These basic results are of course applied toward more virulence-oriented questions in studying how the transcriptome structure is regulated during infection and the consequences of these modifications for the fungus and host.

Former Members

2000
2000
Name
Position
2015
2020
Floriane Pax
Undergraduate Student
2015
2020
Elise Iracane
2015
2020
Rafael Bastos
PhD Student
2015
2020
Liza Dermel
Graduate Student
2015
2020
Patricia A.G. Ferrareze
PhD Student
2015
2020
Corinne Baran
Administrative Staff
2015
2020
Ophélie Lautier
Undergraduate Student
2015
2020
Thomas Damagnez
Graduate Student
2015
2020
Luciana De Oliveira
Post-doc
2019
2022
Juliana Rizzo Balancin
Post-doc

Projects

Project
Ongoing
3 Members

CryptoVIEW: Unraveling pathogenesis of Cryptococcosis using optical and multimodal visualizaion of enigmatic events and virulence aspects in vivo.

Alexandre Alanio (PI)

Cryptococcus neoformans and C. gattii are encapsulated yeasts that can cause life-threatening disease; mainly in immune-suppressed patients, but also in immune-competent individuals. Cryptococcosis affects the lung and may spread to the brain, manifesting itself […]
Project
Ongoing
2 Members

lncRNAs in Cryptococcus neoformans

Guilhem Janbon (PI)

During the last decade, advances in the sequencing technologies have revealed a large set of new eukaryotic RNA molecules. For instance, whereas 75% of the human genome was recently reported to be transcribed only […]
Project
Ongoing
2 Members

Intron dependant gene expression regulation in Cryptococcus neoformans

Guilhem Janbon (PI)

Most Cryptococccus neoformans genes are interrupted by introns, and alternative splicing occurs very often. In order to gain deeper insights into the distribution of introns in the C. neoformans genome, we have used RNA-Seq […]

Transversal Project

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

Antimicrobial resistance

Antimicrobial resistance is dramatically increasing worldwide and is becoming one of the most urgent public health threats. There is an urgent need for actions to reverse the curve of antimicrobial resistance dissemination and to […]

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]

The institut Carnot Pasteur MS

Carnot, label of excellence Founded in 2006, the Carnot Label, granted by the French government, was designed to develop partnership-based research, meaning research conducted by public laboratories in partnership with socio-economic players, primarily industry […]

Equipments

FastPrep • MP • 24- 5G

Broyage de petits volumes de cellules Contact : Frédérique Moyrand (fmoyrand@pasteur.fr or tel:8436 /8311) Location : Fernbach-68-04-13

Biolistic • Biorad PDS-1000/He • PDS-1000/He

Transformation de Cryptococcus Contact : Frédérique Moyrand (fmoyrand@pasteur.fr or tel:8436 /8311) Location : Fernbach-68-04-37A

Lyophilisateur • Christ • Alpha 1-4LDplus

Lyophilisation de cellules et sucres   Contact : Frédérique Moyrand (fmoyrand@pasteur.fr or tel:8436 /8311) Location : Fernbach-68-04-37A

Fundings

Publications

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Contact

Phone: 33 1 45 68 83 56 Email: janbon@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France