The project of the Unit RNA Biology of Fungal Pathogens deals with the study of the structure and plasticity of the transcriptomes of human fungal pathogens. We are mainly using the basidiomycete yeast Cryptococcus neoformans as model, but we are also considering additional pathogenic or non-pathogenic fungi for comparison. We are mainly interested in three dynamic features of the transcriptome: the introns, the UTRs, and the lncRNAs. Part of the project will use global approaches and diverse omics technologies to create an exhaustive list of all the mRNA and lncRNA molecules in the cells in order to study their differential expression in response to environmental cues. We are also using the strength of yeast genetics to decipher the mechanisms regulating the diversity of these features and the level of gene expression in response to these signals. These basic results are of course applied toward more virulence-oriented questions in studying how the transcriptome structure is regulated during infection and the consequences of these modifications for the fungus and host.
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Connections
Members
Former Members
2000
2000
Name
Position
2015
2020
Floriane Pax
Undergraduate Student
2015
2020
Elise Iracane
2015
2020
Rafael Bastos
PhD Student
2015
2020
Liza Dermel
Graduate Student
2015
2020
Patricia A.G. Ferrareze
PhD Student
2015
2020
Corinne Baran
Administrative Staff
2015
2020
Ophélie Lautier
Undergraduate Student
2015
2020
Thomas Damagnez
Graduate Student
2015
2020
Luciana De Oliveira
Post-doc
Projects
Transversal Project
Equipments

FastPrep • MP • 24- 5G
Broyage de petits volumes de cellules Contact : Frédérique Moyrand (fmoyrand@pasteur.fr or tel:8436 /8311) Location : Fernbach-68-04-13
Fundings
Publications
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2020The Added Value of Longitudinal Imaging for Preclinical In Vivo Efficacy Testing of Therapeutic Compounds against Cerebral Cryptococcosis., Antimicrob. Agents Chemother. 2020 06; 64(7): .
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2020Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom, Nucleic Acids Res. 2020 Mar;48(5):2312-2331.
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2020Mating-Type-Specific Ribosomal Proteins Control Aspects of Sexual Reproduction in Cryptococcus neoformans., Genetics 2020 03; 214(3): 635-649.
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2020Muscle Injury Induces Postoperative Cognitive Dysfunction., 2020 02; 10(1): 2768.
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2020Extracellular Vesicles in Fungi: Past, Present, and Future Perspectives., Front Cell Infect Microbiol 2020 ; 10(): 346.
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2019Aspergillus fumigatus exoβ(1-3)glucanases family GH55 are essential for conidial cell wall morphogenesis, Cell. Microbiol. 2019 Dec;21(12):e13102.
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2019From the environment to the host: How non-azole agrochemical exposure affects the antifungal susceptibility and virulence of Cryptococcus gattii, Sci. Total Environ. 2019 Sep;681:516-523.
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2019Studying fungal pathogens of humans and fungal infections: fungal diversity and diversity of approaches, Genes Immun. 2019 05;20(5):403-414.
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2018Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals, PLoS Pathog. 2018 May;14(5):e1007007.
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2018Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators., PLoS Pathog. 2018 05; 14(5): e1006982.
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Contact
Phone: 33 1 45 68 83 56 Email: janbon@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France