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About

The Fungal Biology and Pathogenicity Unit at Institut Pasteur studies the yeasts that are responsible for infections in Humans. In the recent years, fungal infections have become a prominent problem. This in part reflects the increase in immunocompromized individuals (HIV infected individuals, transplant recipients, patients in intensive care units) as well as increased life expectancy. In developed countries, fungal infections are considered as one of the primary causes of nosocomial infections.
Hemiascomycetous yeasts of the genus Candida, and most notably Candida albicans, are responsible for most of the life-threatening systemic fungal infections, especially among intensive-care unit (ICU) patients, cancer patients receiving chemotherapy and patients awaiting transplantation. Life-threatening infections due to Candida species are estimated at > 400,000 cases and ~200,000 deaths per year and represent a real concern because of their high mortality rate, despite the availability of antifungal treatments and other therapeutic approaches.

The main aims of the Fungal Biology and Pathogenicity Unit are to study the biology of C. albicans and other Candida species, the pathophysiology of infections due to these opportunistic pathogens and their epidemiology, with a view to providing solutions for the management of fungal infections. Research within our Unit is therefore focused on four main themes:

Research on these themes relies on functional genomics tools, some of which are developed within our Unit. We, together with the Munro group at the University of Aberdeen, have developed the C. albicans ORFeome, a plasmid collection for >5200 C. albicans ORFs and are proceeding towards the establishment of collections of barcoded overexpression plasmids and strains.

Our Unit forms part of the Mycology Department at Institut Pasteur. We are also affiliated with the department of Genomes and Genetics at Institut Pasteur, and with the Microbiology and the Food Chain Department at the National Institute for Agronomic Research (USC 2019).

 

Members

Projects

Transversal Project

Equipments

Sunrise (4) • Tecan • Sunrise (4)

Group of 4 plate-readers, absorbance, temperature control, microplate shaking kinetics Location : Fernbach – 4 – 68-E4-17 Personnes à contacter : Natacha Sertour (natacha.sertour@pasteur.fr or tel: 8619) Unité Biologie et Pathogénicité Fongiques Unités autorisées […]

Infinite 200 • Tecan • Infinite 200

Plate-reader, fluorescence (top and bottom), luminescence and absorbance, temperature control, microplate shaking, kinetics, equipped with an injector Location : Fernbach – 4 – 68-E4-17 Personnes à contacter : Natacha Sertour (natacha.sertour@pasteur.fr or tel: 8619) […]

PHENOBOOT • Singer • PHENOBOOT

The PhenoBooth Colony Counter is a fast, super-easy to use, closed-chamber Colony Counter for imaging and analysis of colonies on agar. It uses a scientific grade, 13 megapixel HD camera and 4-channel, flat-field SpectraStar™ […]

ROTOR HDA • Singer • ROTOR HDA

Bench-top robot for the picking and replating of yeast, fungi, bacteria and algae colonies at densities 96, 384, 1536 and 6144. Can be used for duplicating mutant and clone libraies, re-plating cells from liquid […]

MacsQuant • Miltenyi Biotech • MacsQuant

3-colour benchtop flow-cytometer (405, 488, 635 nm), 96-well plate handler Location : Fernbach – 4 – 68-E4-17 Personnes à contacter: Mélanie Legrand (melanie.legrand@pasteur.fr or tel: 3126) Unité Biologie et Pathogénicité Fongiques Unités autorisées à […]

GentleMacs Dissociator • Miltenyi Biotech • GentleMacs Dissociator

The gentleMACS™ Dissociator is a benchtop instrument for the semi-automated dissociation of tissues into single-cell suspensions or thorough homogenates. A single sample or two samples in parallel can be processed. Two types of unique […]

Fundings

Publications

News

The Fungal Biology and Pathogenicity Unit is awarded funding from the Swiss National Science Foundation under the Sinergia program to study genetic determinants of Candida albicans pathogenicity (May 2017)
An interdisciplinary SNSF-funded Sinergia project has been awarded to the University of Zürich (Prof. Salomé LeibundGut), University of Lausanne (Prof. Dominique Sanglard), Ecole Polytechnique Fédérale Lausanne (Dr. Sandor Kasas) and Institut Pasteur (Dr. Christophe d’Enfert and Dr. Guillaume Laval).
The project focuses on the fungal pathogen Candida albicans and is aimed to identify fungal genetic factors associated with the variability in the outcomes of fungal-host interactions. Genetic factors will be identified using several parallel approaches based on the association of diverse phenotypes (obtained in vitro, in vivo and through transcriptomics) with whole genomes data from a collection of clinical isolates.
Two post-doctoral positions are available at Institut Pasteur to work on this project.

Dr. Jeanne Ropars, post-doctoral fellow in the Fungal Biology and Pathogenicity Unit, is appointed at the CNRS (june 2017)
From 2018, Jeanne will join the Laboratoire d’Ecologie, Systématique et Evolution to work on genome evolution in fungi used for cheese-making.

Dr. Mennat El-Ghalid, post-doctoral fellow in the Fungal Biology and Pathogenicity Unit, becomes one of the 21 2017 TED Global Fellows (may 2017)
The TED Fellows program provides transformational support to an international community of 436 visionaries who collaborate across disciplines to create positive change around the world. Mennat El Ghalid will deliver a talk at TED Global this August in Arusha, Tanzania joining a growing list of 436 other Fellows from 94 countries around the world. It will be the first time in a decade that TED will be held in Africa. see news on CNN website

 Dr. Sadri Znaidi, scientist at Institut Pasteur in Tunis, is awarded the status of affiliate researcher of the Institut Pasteur International Network, to work in the Fungal Biology and Pathogenicity Unit (march 2017)
Dr. Sadri Znaidi, assistant biologist at the Laboratory of Molecular Microbiology, Vaccinology and Biotechnological Development at the Institut Pasteur in Tunis, was awarded the status of affiliate researcher of the Institut Pasteur International Network. The RIIP Affiliate program strengthens exchanges and collaborations between researchers of the Network and those of the Institut Pasteur. see news.