Previously controlled bacterial infections can re-emerge due to antibiotic resistance or vaccine escape. Species of pathogenic bacteria comprise a huge amount of genotypic and phenotypic diversity. Our lab is interested in the diversity, evolution and epidemiology of bacterial pathogens and in the links between the genotypic and phenotypic (ecology, colonization, transmission, virulence, antibiotic resistance, immune response) diversity of the strains within particular species. We focus on three pathogens of high public health importance: Klebsiella pneumoniae, which causes various types of infections including urinary tract, respiratory and blood infections; Bordetella pertussis, the agent of whooping cough; and Corynebacterium diphtheriae, the agent of diphtheria. We combine epidemiological surveillance, microbiology, genomics, proteomics, bioinformatics and immunological approaches as well as in-vivo and in-vitro models of infection. We also develop and maintain genomic libraries of bacterial genotypes and strain nomenclatures that facilitate global collaborative surveillance and population biology of bacterial pathogens.
About
Members
Former Members
Courses
Bacterial strain nomenclatures applied to international epidemiological surveillance: A Theoretical and Hands-on Course
This two-day course will provide participants both theory and hands-on practical exercises on bacterial strain nomenclatures using the core genome MLST concept. Focus will be put on the BIGSdb software tool and database and […]
Projects
Transversal Project
Software
Tools
Equipments
Fundings
Publications
Download-
2022A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings., Nat Microbiol 2022 Dec; 7(12): 2054-2067.
-
2022Corynebacterium ulcerans as filamentous branching rods., Clin Microbiol Infect 2022 Nov; (): .
-
2022Detection of Klebsiella pneumoniae human gut carriage: a comparison of culture, qPCR, and whole metagenomic sequencing methods., Gut Microbes ; 14(1): 2118500.
-
2022Limited Transmission of Klebsiella pneumoniae among Humans, Animals, and the Environment in a Caribbean Island, Guadeloupe (French West Indies)., Microbiol Spectr 2022 Sep; (): e0124222.
-
2022A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies., Nat Commun 2022 Jul; 13(1): 3807.
-
2022Non-toxigenic Corynebacterium diphtheriae in hallux ulceration., J Infect Dev Ctries 2022 Jun; 16(6): 1118-1121.
-
2022A dual barcoding approach to bacterial strain nomenclature: Genomic taxonomy of Klebsiella pneumoniae strains, Mol Biol Evol. 2022 Jun; msac135.
-
2022Association between the COVID-19 pandemic and pertussis derived from multiple nationwide data sources, France, 2013 to 2020., Euro Surveill 2022 Jun; 27(25): .
-
2022Transmission of Klebsiella strains and plasmids within and between grey-headed flying fox colonies., Environ Microbiol 2022 May; (): .
-
2022In Vitro and In Vivo Assessments of Two Newly Isolated Bacteriophages against an ST13 Urinary Tract Infection Klebsiella pneumoniae., Viruses 2022 05; 14(5): .
-
+View full list of publications
Contact
Phone: +33 1 45 68 80 05 E-mail: isabelle.moulherat@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France