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About

Previously controlled bacterial infections can re-emerge due to antibiotic resistance or vaccine escape. Species of pathogenic bacteria comprise a huge amount of genotypic and phenotypic diversity. Our lab is interested in the diversity, evolution and epidemiology of bacterial pathogens and in the links between the genotypic and phenotypic (ecology, colonization, transmission, virulence, antibiotic resistance, immune response) diversity of the strains within particular species. We focus on three pathogens of high public health importance: Klebsiella pneumoniae, which causes various types of infections including urinary tract, respiratory and blood infections; Bordetella pertussis, the agent of whooping cough; and Corynebacterium diphtheriae, the agent of diphtheria. We use genomics, proteomics, bioinformatics and immunological approaches as well as in-vivo and in-vitro models of infection. We also develop databases of bacterial genotypes and strain nomenclatures that facilitate global collaborative surveillance of bacterial pathogens.

Members

Sylvain Brisse
Head of Structure
Head
Edgar Badell-Ocando
Research Engineer
Valérie Bouchez
Research Engineer
Annick Carmi-Leroy
Technician
Sandra Corre
Research Engineer
Melody Dazas
Technician
Sophie Guillot
Research Engineer
Annie Landier
Technician
Juan Sebastián López Fernández
Post-doc
Isabelle Moulherat
Administrative Staff
Leonardo-Gabriel Panunzi
Post-doc
Carla Parada Rodrigues
Non-permanent Researcher
Virginie Passet
Nadine Pouradier
Technician
Julie Toubiana
Deputy Director of National Reference Center

Projects

project
Ongoing
5 Members

MedVetKlebs: Klebsiella pneumoniae from ecology to source attribution and transmission control

Sylvain Brisse (PI)

Klebsiella pneumoniae (hereafter, K. pneumoniae) is a major cause of hospital-acquired infections such as urinary infections, pneumonia, bloodstream infections, infections in newborns and in intensive-care unit patients. Some hypervirulent strains also cause community infections […]
project
Ongoing
4 Members

SPARK: Transmission of multidrug resistant Klebsiella clones and genes – a One Health approach

Sylvain Brisse (PI)

The SPARK (Spread of Population-wide Antibiotic Resistance in Klebsiella) project, funded by the JPIAMR instrument of the European Union H2020 programme, seeks to address the complex issue of transmission of antimicrobial resistance genes and […]
project
Ongoing
5 Members

Bordetella and whooping cough: Population Biology and Vaccination

Sylvain Brisse (PI)

Our research on Bordetella covers the population biology and epidemiology of various Bordetella species, including B. pertussis, the major agent of whooping cough; vaccine improvements; and the impact of vaccination on population evolution. Current […]
project
Ongoing
4 Members

Diphtheria and Corynebacteria: diversity, evolution and epidemiology

Sylvain Brisse (PI)

Our project on Corynebacterium diphtheriae and related bacterial pathogenic species aims at defining the diversity, evolution and epidemiology of the agents of diphtheria. We use genomics, transcriptomics and proteomics to define the population dynamics […]
project
Ongoing
4 Members

Perilic

Fabien Taieb (PI)

A descriptive analysis of pertussis in 4 different regions of the world Coordinated by Fabien Taieb, physician affiliated with the Center for Translational Science at the Institut Pasteur, responsible for the coordination of the […]
project
Ongoing
4 Members

Population biology of the bacterial pathogen Klebsiella pneumoniae

Sylvain Brisse (PI)

Klebsiella pneumoniae is one of the most urgent threats to public health given its increasing resistance to antimicrobial agents including carbapenems, considered as last-resort antibiotics.  In this project we aim to understand the ecological, epidemiological and […]
project
Ongoing
9 Members

Genomic databases for bacterial epidemiology, population biology and strain nomenclature

Sylvain Brisse (PI)

High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based typing systems are being developed to replace or complement classical epidemiological markers and have […]
project
Ongoing
4 Members

Bioinformatics developments for whole-genome sequencing of microbial agents for epidemiological surveillance

Sylvain Brisse (PI)

The PIBnet initiative is a large collaborative program that aims at reinforcing microbial strain collection management and characterization approaches and technologies. It involves National Reference Centers, WHO-collaborative centers, biological resources centers and other microbiological expertise laboratories, together […]

Fundings

Publications

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Contact

Phone: +33 1 45 68  80 05

E-mail: isabelle.moulherat@pasteur.fr

Address 25-28 Rue du Docteur Roux 75015, Paris France