Previously controlled bacterial infections can re-emerge due to antibiotic resistance or vaccine escape. Species of pathogenic bacteria comprise a huge amount of genotypic and phenotypic diversity. Our lab is interested in the diversity, evolution and epidemiology of bacterial pathogens and in the links between the genotypic and phenotypic (ecology, colonization, transmission, virulence, antibiotic resistance, immune response) diversity of the strains within particular species. We focus on three pathogens of high public health importance: Klebsiella pneumoniae, which causes various types of infections including urinary tract, respiratory and blood infections; Bordetella pertussis, the agent of whooping cough; and Corynebacterium diphtheriae, the agent of diphtheria. We combine epidemiological surveillance, microbiology, genomics, proteomics, bioinformatics and immunological approaches as well as in-vivo and in-vitro models of infection. We also develop and maintain genomic libraries of bacterial genotypes and strain nomenclatures that facilitate global collaborative surveillance and population biology of bacterial pathogens.
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About
Members
Former Members
2000
2000
Name
Position
2017
2019
Marina Barros
Post-doc
2017
2019
Melody Dazas
Technician
2017
2019
Sandra Corre
Research Engineer
2017
2019
Leonardo-Gabriel Panunzi
Post-doc
2017
2019
Juan Sebastián López Fernández
Post-doc
2017
2019
Nadine Pouradier
Technician
2017
2019
Pierre Tonnerre
Post-doc
2017
2019
Pauline Leroux
Graduate Student
2019
2021
Nadia Fernandes Dawson
Post-doc
Jobs
Courses
Bacterial strain nomenclatures applied to international epidemiological surveillance: A Theoretical and Hands-on Course
This two-day course will provide participants both theory and hands-on practical exercises on bacterial strain nomenclatures using the core genome MLST concept. Focus will be put on the BIGSdb software tool and database and […]
2018-10-29 10:00:00
2018-10-30 17:00:00
Europe/Paris
Bacterial strain nomenclatures applied to international epidemiological surveillance: A Theoretical and Hands-on Course
This two-day course will provide participants both theory and hands-on practical exercises on bacterial strain nomenclatures using the core genome MLST concept. Focus will be put on the BIGSdb software tool and database and […]
25 Rue du Dr Roux, 75015 Paris, France
Projects
Transversal Project
Software
Tools
Equipments
Fundings
Publications
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2022A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies., Nat Commun 2022 Jul; 13(1): 3807.
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2022Non-toxigenic Corynebacterium diphtheriae in hallux ulceration., J Infect Dev Ctries 2022 Jun; 16(6): 1118-1121.
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2022A dual barcoding approach to bacterial strain nomenclature: Genomic taxonomy of Klebsiella pneumoniae strains, Mol Biol Evol. 2022 Jun; msac135.
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2022Association between the COVID-19 pandemic and pertussis derived from multiple nationwide data sources, France, 2013 to 2020., Euro Surveill 2022 Jun; 27(25): .
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2022Transmission of Klebsiella strains and plasmids within and between grey-headed flying fox colonies., Environ Microbiol 2022 May; (): .
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2022In Vitro and In Vivo Assessments of Two Newly Isolated Bacteriophages against an ST13 Urinary Tract Infection Klebsiella pneumoniae., Viruses 2022 05; 14(5): .
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2022Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017., Sci Rep 2022 Apr; 12(1): 6871.
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2022Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis., Sci Transl Med 2022 Apr; 14(642): eabn3253.
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2022Pertussis surveillance results from a French general practitioner network, France, 2017 to 2020., Euro Surveill 2022 Apr; 27(17): .
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2022In vitro and in silico parameters for precise cgMLST typing of Listeria monocytogenes., BMC Genomics 2022 Mar; 23(1): 235.
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Contact
Phone: +33 1 45 68 80 05 E-mail: isabelle.moulherat@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France