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© Research
Project

Interaction dynamique entre chromosomes eucaryotes : impact sur la stabilité du génome (DICIG)

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
31
May 2011
Status
Ongoing
Members
1
Structures
1

About

Ce projet vise à comprendre les interactions fonctionnelles et mécaniques entre chromosomes, périphérie nucléaire et cytosquelette, ainsi que leur influence sur la stabilité génomique, à travers des approches in vivo et in vitro chez un modèle eucaryote, la levure Saccharomyces cerevisiae. Des études génomiques, combinées à des analyses de microscopie quantitative, permettent aux chercheurs de décrire très finement l’organisation des chromosomes les uns par rapport aux autres, dans différents fonds génétique. L’expérimentation génétique leur permet de mesurer l’importance de cette organisation dans le bon déroulement de processus liés au métabolisme de l’ADN.

Fundings