Our laboratory uses the mouse as a mammalian model to decipher the genetic control of complex traits which result from interactions between multiple genes and non-genetic factors. We are primarily focusing on the susceptibility to several bacterial and viral infectious diseases, in particular to life-threatening emerging pathogens. Our approach is to take advantage of the genetic variation present in collections of mouse strains derived from intersubspecific crosses.
About
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Courses
Mouse Genetics Course
This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
Projects
Transversal Project
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Publications
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2023SARS-CoV-2-related bat virus behavior in human-relevant models sheds light on the origin of COVID-19., EMBO Rep 2023 Mar; (): e56055.
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2022Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response., J Neuroinflammation 2022 Dec; 19(1): 307.
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2022Olfactory outcomes in Zika virus-associated Guillain-Barré syndrome., Eur J Neurol 2022 Jun; (): .
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2021A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters., Nat Commun 2021 11; 12(1): 6277.
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2021Host genetic control of natural killer cell diversity revealed in the Collaborative Cross., Proc Natl Acad Sci U S A 2021 Mar; 118(10): .
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2021Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains., Nat Commun 2021 02; 12(1): 916.
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2021The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice., Mamm Genome 2021 02; 32(1): 30-37.
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2020Host genetic susceptibility to viral infections: the role of type I interferon induction., Genes Immun 2020 12; 21(6-8): 365-379.
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2020Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations., Science 2020 11; 370(6519): 991-996.
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2020Animal and translational models of SARS-CoV-2 infection and COVID-19., Mucosal Immunol 2020 Aug; (): .
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Contact
Phone:+33 1 45 68 89 55 Email: xavier.montagutelli@pasteur.fr Address : 25-28 Rue du Docteur Roux 75015, Paris France