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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique

About

Our laboratory uses the mouse as a mammalian model to decipher the genetic control of complex traits which result from interactions between multiple genes and non-genetic factors. We are primarily focusing on the susceptibility to several bacterial and viral infectious diseases, in particular to life-threatening emerging pathogens. Our approach is to take advantage of the genetic variation present in collections of mouse strains derived from intersubspecific crosses.

Former Members

2000
2000
Name
Position
2018
2021
Anaïs Cazals
PhD Student
2016
2019
Caroline Manet
PhD Student
1983
2018
Dominique Simon
Research Engineer
2014
2017
Jing Zhang
PhD Student

Courses

09:00
03
Jan 2022
Course

Mouse Genetics Course

  This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
Mouse Genetics
Early Mammalian Development & Stem Cell Biology
Epigenomics, Proliferation and the Identity of Cells – EPIC
Developmental and Stem Cell Biology
Genomes and Genetics
Xavier Montagutelli
Michel Cohen-Tannoudji
2022-01-03 09:00:00 2022-02-08 18:00:00 Europe/Paris Mouse Genetics Course   This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Projects

Project
Ongoing
9 Members

Host genetic susceptibility to Zika virus

Xavier Montagutelli (PI)

Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]
Project
Ongoing
7 Members

Mouse models for Covid-19

Xavier Montagutelli (PI)

Mice are not naturally susceptible to SARS-CoV-2 due to poor binding of the virus spike to the mouse cellular receptor ACE2. We have developed a mouse-adapted strain of SARS-CoV-2 which efficiently replicates in the […]
Project
Ongoing
5 Members

Host genetic susceptibility to Salmonelloses

Jean Jaubert (PI)

Salmonella enterica infections in humans are responsible for three major clinical syndromes, typhoid fever caused by host-specific Salmonella, a diarrheal disease known as salmonellosis caused by several non-typhoidal Salmonella (NTS) and invasive NTS (iNTS) […]
Project
Ongoing
3 Members

Collaborative Cross initiatives

Xavier Montagutelli (PI)

Although mouse models have been invaluable to study human diseases, classical mouse laboratory strains (figure, left panel, colored dots) present much smaller genetic diversity than the human population, limiting the range of phenotypic variations […]
Project
Ongoing
8 Members

Pathogenicity and resistance to Rift Valley Fever virus.

Xavier Montagutelli (PI)

Rift Valley fever (RVF) is a an arthropod-borne emerging viral disease that primarily affects domesticated animals (such as cattle, sheep and goats) and humans, with recent outbreaks in sub-Saharan Africa, Madagascar, and the Arabian […]
Project
Ongoing
5 Members

Humoral immunity & human monoclonal antibodies against SARS-CoV-2

Hugo Mouquet (PI)

The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]

Transversal Project

Drug Discovery & Screening at Institut Pasteur

The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]

Fundings

Publications

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Contact

Phone:+33 1 45 68 89 55 Email: xavier.montagutelli@pasteur.fr Address : 25-28 Rue du Docteur Roux 75015, Paris France