Our laboratory uses the mouse as a mammalian model to decipher the genetic control of complex traits which result from interactions between multiple genes and non-genetic factors. We are primarily focusing on the susceptibility to several bacterial and viral infectious diseases, in particular to life-threatening emerging pathogens. Our approach is to take advantage of the genetic variation present in collections of mouse strains derived from intersubspecific crosses.
Mouse Genetics Course
This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
Host genetic susceptibility to Zika virus
Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]
Mouse models for Covid-19
Mice are not naturally susceptible to SARS-CoV-2 due to poor binding of the virus spike to the mouse cellular receptor ACE2. We have developed a mouse-adapted strain of SARS-CoV-2 which efficiently replicates in the […]
Host genetic susceptibility to Salmonelloses
Salmonella enterica infections in humans are responsible for three major clinical syndromes, typhoid fever caused by host-specific Salmonella, a diarrheal disease known as salmonellosis caused by several non-typhoidal Salmonella (NTS) and invasive NTS (iNTS) […]
Collaborative Cross initiatives
Although mouse models have been invaluable to study human diseases, classical mouse laboratory strains (figure, left panel, colored dots) present much smaller genetic diversity than the human population, limiting the range of phenotypic variations […]
Pathogenicity and resistance to Rift Valley Fever virus.
Rift Valley fever (RVF) is a an arthropod-borne emerging viral disease that primarily affects domesticated animals (such as cattle, sheep and goats) and humans, with recent outbreaks in sub-Saharan Africa, Madagascar, and the Arabian […]
Humoral immunity & human monoclonal antibodies against SARS-CoV-2
The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]
Emerging Infectious Diseases
Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
2021Host genetic control of natural killer cell diversity revealed in the Collaborative Cross., Proc Natl Acad Sci U S A 2021 03; 118(10): .
2021Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains., Nat Commun 2021 02; 12(1): 916.
2021The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice., Mamm Genome 2021 02; 32(1): 30-37.
2020Host genetic susceptibility to viral infections: the role of type I interferon induction., Genes Immun 2020 12; 21(6-8): 365-379.
2020Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations., Science 2020 11; 370(6519): 991-996.
2020Animal and translational models of SARS-CoV-2 infection and COVID-19., Mucosal Immunol 2020 Aug; (): .
2020NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice., Nat Commun 2020 07; 11(1): 3281.
2020Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis., Sci Rep 2020 May; 10(1): 8734.
202033rd international mammalian genome conference: meeting highlights., Mamm. Genome 2020 04; 31(3-4): 69-76.
2020Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b., J Virol 2020 01; 94(3): .
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