Timeline

Moshe Yaniv

Honorary President of the Departement

31 Jan 2020

event

!!! CANCELLED !!! François Jacob & Jacques Monod Anniversary Symposium – Friday, June 19th, 2020 – Institut Pasteur, Paris

21 Feb 2019

event

François Jacob Conference

20 Feb 2019

event

130 Years of Institut Pasteur: Celebrating Science

06 Apr 2017

event

EMBO Conference on Hijacking host signalling and epigenetic mimicry during infections

17 Jan 2017

event

SEMINAR ” Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress “

02 Jun 2016

event

Developmental and Stem Cell Biology & Neuroscience Departments joint seminars

21 May 2014

publication

With François Jacob, from temperature sensitive mutants of Escherichia coli to mouse development and diseases

22 Mar 2014

publication

Chromatin remodeling: from transcription to cancer

20 May 2013

publication

François Jacob (1920-2013)

24 Apr 2011

publication

The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis

22 Mar 2011

publication

The 50th anniversary of the publication of the operon theory in the Journal of Molecular Biology: past, present and future

18 Nov 2009

publication

Human papillomavirus type 8 E2 protein unravels JunB/Fra-1 as an activator of the beta4-integrin gene in human keratinocytes

20 May 2009

publication

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity

17 Apr 2009

publication

Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets

10 Apr 2009

publication

Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia

15 Dec 2008

publication

The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer

09 Dec 2008

publication

Small DNA tumour viruses and their contributions to our understanding of transcription control

28 Mar 2008

publication

Chromosomes and expression mechanisms: bringing together the roles of DNA, RNA and proteins

08 Jan 2008

publication

JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation

08 Aug 2007

publication

Deciphering AP-1 function in tumorigenesis: fra-ternizing on target promoters

16 Jul 2007

publication

Characterization of mammary tumors from Brg1 heterozygous mice

02 Jun 2007

publication

Dimer composition and promoter context contribute to functional cooperation between AP-1 and NFAT

08 Mar 2007

publication

Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription

26 Dec 2006

publication

Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation

01 Dec 2006

publication

JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation

01 Apr 2006

publication

Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex

11 Dec 2005

publication

The human SWI/SNF subunit Brm is a regulator of alternative splicing

01 Oct 2005

publication

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation

01 Sep 2005

publication

The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation

01 Sep 2005

publication

Alpha/beta interferon differentially modulates the clearance of cytoplasmic encapsidated replication intermediates and nuclear covalently closed circular hepatitis B virus (HBV) DNA from the livers of hepatocyte nuclear factor 1alpha-null HBV transgenic mice

29 Aug 2005

publication

Lack of JunD promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heart

15 Jun 2005

publication

A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network

01 May 2005

publication

SWI/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation

31 Mar 2005

publication

AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene

01 Mar 2005

publication

[Oxidative stress and angiogenesis: major role of AP-1]

17 Sep 2004

publication

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

03 Sep 2004

publication

Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene

13 May 2004

publication

Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release

23 Apr 2004

publication

Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3

18 Mar 2004

publication

A transcriptional network in polycystic kidney disease

15 Dec 2003

publication

Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation

05 Sep 2003

publication

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

01 Sep 2003

publication

JunD protects against chronic kidney disease by regulating paracrine mitogens

15 Jun 2003

publication

c-jun regulation and function in the developing hindbrain

01 Apr 2003

publication

HMG-I(Y) and the CBP/p300 coactivator are essential for human papillomavirus type 18 enhanceosome transcriptional activity

01 Jan 2003

publication

Impaired intervertebral disc formation in the absence of Jun

01 Oct 2002

publication

Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus

13 Sep 2002

publication

Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha

01 Jul 2002

publication

Promoter specificity and biological activity of tethered AP-1 dimers

01 Apr 2002

publication

Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta

14 Feb 2002

publication

Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression

01 Feb 2002

publication

SWI/SNF chromatin remodeling and cancer

01 Jan 2002

publication

Frequent alterations of the beta-catenin protein in cancer of the uterine cervix

27 Nov 2001

publication

A yeast homolog of chromatin assembly factor 1 is involved in early ribosome assembly

01 Nov 2001

publication

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

31 Aug 2001

publication

Chromatin modifiers and tumor suppression

19 Jul 2001

publication

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri

01 Jul 2001

publication

A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation

01 Jun 2001

publication

Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes

28 May 2001

publication

When the SWI/SNF complex remodels…the cell cycle

30 Apr 2001

publication

The mammalian Jun proteins: redundancy and specificity

17 Apr 2001

publication

Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity

20 Mar 2001

publication

The human brm protein is cleaved during apoptosis: the role of cathepsin G

01 Mar 2001

publication

Nuclear covalently closed circular viral genomic DNA in the liver of hepatocyte nuclear factor 1 alpha-null hepatitis B virus transgenic mice

01 Dec 2000

publication

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

01 Nov 2000

publication

An enhanceosome containing the Jun B/Fra-2 heterodimer and the HMG-I(Y) architectural protein controls HPV 18 transcription

01 Nov 2000

publication

JunD protects cells from p53-dependent senescence and apoptosis

01 Oct 2000

publication

HNF1alpha controls renal glucose reabsorption in mouse and man

01 May 2000

publication

Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression

01 Jan 2000

publication

Targeted disruption of the murine junD gene results in multiple defects in male reproductive function

10 Dec 1999

publication

Anatomy of a homeoprotein revealed by the analysis of human MODY3 mutations

01 Dec 1999

publication

Expression of the vHNF1/HNF1beta homeoprotein gene during mouse organogenesis

01 Nov 1999

publication

Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation

22 Oct 1999

publication

ATP-dependent chromatin remodelling: SWI/SNF and Co. are on the job

01 Oct 1999

publication

Retinal photoreceptors are apoptosis-competent in the absence of JunD/AP-1

01 Oct 1999

publication

Herniation of calcified intervertebral disk in a lumbar vertebral body presenting as acute scoliosis in a child. A case report and literature review

12 Aug 1999

publication

Papillomavirus E2 induces p53-independent apoptosis in HeLa cells

29 Jul 1999

publication

Rebuilding the road to cancer

01 Jun 1999

publication

The activity of mammalian brm/SNF2alpha is dependent on a high-mobility-group protein I/Y-like DNA binding domain

01 Apr 1999

publication

The mammalian SWI/SNF complex and the control of cell growth

01 Dec 1998

publication

Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha)

01 Oct 1998

publication

Stress-activated protein kinases are negatively regulated by cell density

18 Sep 1998

publication

Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

01 Aug 1998

publication

Signal transduction pathways and modulation of gene activity

15 May 1998

publication

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

15 Mar 1998

publication

The human papillomavirus type 18 (HPV18) replication protein E1 is a transcriptional activator when interacting with HPV18 E2

01 Jan 1998

publication

ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex

01 Dec 1997

publication

Different mechanisms contribute to the E2-mediated transcriptional repression of human papillomavirus type 18 viral oncogenes

01 Dec 1997

publication

A set of polyclonal and monoclonal antibodies reveals major differences in post-translational modification of the rat HNF1 and vHNF1 homeoproteins

14 Oct 1997

publication

RB and hbrm cooperate to repress the activation functions of E2F1

01 Sep 1997

publication

Hepatocyte nuclear factor 1alpha gene inactivation impairs chromatin remodeling and demethylation of the phenylalanine hydroxylase gene

01 Jun 1997

publication

A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B

21 Apr 1997

publication

Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix

15 Apr 1997

publication

The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity

01 Apr 1997

publication

Induction of apoptosis by the transcription factor c-Jun

28 Feb 1997

publication

Synergistic transcriptional-activation by the papillomavirus E2 protein occurs after DNA binding and correlates with a change in chromatin structure

21 Feb 1997

publication

Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome

20 Feb 1997

publication

Transformation by ras modifies AP1 composition and activity

20 Feb 1997

publication

Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts

01 Feb 1997

publication

Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis

01 Oct 1996

publication

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex

01 Jul 1996

publication

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis

01 Mar 1996

publication

A single element mediates glucocorticoid hormone response of HPV18 with no functional interactions with AP1 or hbrm

23 Feb 1996

publication

Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

01 Jan 1996

publication

Two RAREs and an overlapping CRE are involved in the hepatic transcriptional regulation of the Q10 MHC class I gene

01 Jan 1996

publication

E2 proteins: modulators of papillomavirus transcription and replication

11 Dec 1995

publication

Control of HPV 18 DNA replication by cellular and viral transcription factors

11 Apr 1995

publication

A human protein with homology to Saccharomyces cerevisiae SNF5 interacts with the potential helicase hbrm

16 Jan 1995

publication

The bovine papillomavirus 1 E2 protein contains two activation domains: one that interacts with TBP and another that functions after TBP binding

01 Apr 1994

publication

Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization

25 Feb 1994

publication

Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras

01 Feb 1994

publication

The bovine papillomavirus type 1 (BPV1) replication protein E1 modulates transcriptional activation by interacting with BPV1 E2

01 Jan 1994

publication

Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure

15 Dec 1993

publication

Functional interference between the Spi-1/PU.1 oncoprotein and steroid hormone or vitamin receptors

01 Dec 1993

publication

The transactivation potential of variant hepatocyte nuclear factor 1 is modified by alternative splicing

01 Nov 1993

publication

A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor

15 Oct 1993

publication

The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1

01 Aug 1993

publication

Interleukin 6 induces DNA binding activity of AP1 in M1 myeloblastic cells but not in a growth resistant cell derivative

01 Aug 1993

publication

In vitro transforming capacities of mouse c-jun:junD chimeric genes

01 Jan 1993

publication

The HNF1 C-terminal domain contributes to transcriptional activity and modulates nuclear localisation

15 Oct 1992

publication

A potent enhancer made of clustered liver-specific elements in the transcription control sequences of human alpha 1-microglobulin/bikunin gene

01 Sep 1992

publication

HNF1, a homeoprotein member of the hepatic transcription regulatory network

25 Aug 1992

publication

Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1)

27 Jul 1992

publication

How do eukaryotic activator proteins stimulate the rate of transcription by RNA polymerase II?

01 Jun 1992

publication

Two AP1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes

01 Dec 1991

publication

Structural analysis of the human papillomavirus type 16-E2 transactivator with antipeptide antibodies reveals a high mobility region linking the transactivation and the DNA-binding domains

01 Dec 1991

publication

vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression

15 Nov 1991

publication

Wild-type p53 can down-modulate the activity of various promoters

01 Nov 1991

publication

The papillomavirus E2 protein: a factor with many talents

01 Nov 1991

publication

NFY or a related CCAAT binding factor can be replaced by other transcriptional activators for co-operation with HNF1 in driving the rat albumin promoter in vivo

15 Oct 1991

publication

Overexpression of c-jun, junB, or junD affects cell growth differently

01 Oct 1991

publication

Several different upstream promoter elements can potentiate transactivation by the BPV-1 E2 protein

01 Oct 1991

publication

Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse

01 Sep 1991

publication

The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex

01 Aug 1991

publication

Degradation of transcription factors, c-Jun and c-Fos, by calpain

01 Aug 1991

publication

Unregulated expression of c-Jun or c-Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells

11 Jul 1991

publication

Two members of an HNF1 homeoprotein family are expressed in human liver

01 Jun 1991

publication

vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1

01 Jun 1991

publication

Nuclear oncogenes

01 May 1991

publication

Two DNA-bound E2 dimers are required for strong transcriptional activation and for cooperation with cellular factors in most cells

01 Apr 1991

publication

Transfected mouse c-jun can inhibit transformation of primary rat embryo fibroblasts

01 Jan 1991

publication

[Functional interaction between estrogen receptor and proto-oncogene products c-Jun and c-Fos]

11 Oct 1990

publication

A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain

01 Oct 1990

publication

Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype

01 Sep 1990

publication

Protein-binding elements in the promoter region of the mouse p53 gene

01 Sep 1990

publication

Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse

01 Aug 1990

publication

Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance

01 Jul 1990

publication

Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1

01 Jul 1990

publication

Fos and Jun oncogenes transactivate chimeric or native promoters containing AP1/GCN4 binding sites in plant cells

01 Jun 1990

publication

Control of papillomavirus gene expression

01 Apr 1990

publication

Anatomy of the rat albumin promoter

01 Jan 1990

publication

Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man

01 Dec 1989

publication

Stimulation of protein kinase C or protein kinase A mediated signal transduction pathways shows three modes of response among serum inducible genes

01 Nov 1989

publication

The rat albumin promoter: cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation

01 Nov 1989

publication

The rat albumin promoter is composed of six distinct positive elements within 130 nucleotides

01 Nov 1989

publication

Jun DNA-binding is modulated by mutations between the leucines or by direct interaction of fos with the TGACTCA sequence

01 Oct 1989

publication

The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes

01 Jun 1989

publication

Control elements situated downstream of the major transcriptional start site are sufficient for highly efficient polyomavirus late transcription

01 May 1989

publication

Characterization of junD: a new member of the jun proto-oncogene family

01 Jan 1989

publication

Functional analysis of the papilloma virus E2 trans-activator in Saccharomyces cerevisiae

01 Dec 1988

publication

A dimer of BPV-1 E2 containing a protease resistant core interacts with its DNA target

01 Dec 1988

publication

Use of retroviral vectors for mapping of splice sites in cottontail rabbit papillomavirus

01 Nov 1988

publication

Interplay of viral and cellular proteins along the long control region of human papillomavirus type 18

01 Sep 1988

publication

Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains

11 Aug 1988

publication

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

01 Aug 1988

publication

A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells

01 Aug 1988

publication

Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins

01 May 1988

publication

Study of the E2 gene product of the cottontail rabbit papillomavirus reveals a common mechanism of transactivation among papillomaviruses

01 May 1988

publication

Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts

01 Feb 1988

publication

Several distinct “CCAAT” box binding proteins coexist in eukaryotic cells

01 Nov 1987

publication

gal4 transcription activator protein of yeast can function as a repressor in Escherichia coli

14 Aug 1987

publication

Factors involved in control of tissue-specific expression of albumin gene

16 Jul 1987

publication

Induction of a factor that binds to the polyoma virus A enhancer on differentiation of embryonal carcinoma cells

01 Jul 1987

publication

Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system

01 May 1987

publication

Two different factors bind to the alpha-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers

15 Jan 1987

publication

Enhancer-mediated activation of a growth-regulated promoter

01 Jan 1987

publication

Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens

22 Dec 1986

publication

Molecular analysis of the interaction between an enhancer binding factor and its DNA target

01 Aug 1986

publication

Studies on the expression of an H-2K/human growth hormone fusion gene in giant transgenic mice

01 Jan 1986

publication

Structure of transcriptionally active chromatin

01 Jan 1986

publication

Production of spliced DNA copies of the cottontail rabbit papillomavirus genome in a retroviral vector

01 Oct 1985

publication

Specific interaction of cellular factors with the B enhancer of polyoma virus

01 Mar 1985

publication

Genomic structure of the cottontail rabbit (Shope) papillomavirus

01 Mar 1985

publication

Fine structure of the cottontail rabbit papillomavirus mRNAs expressed in the transplantable VX2 carcinoma

01 Jan 1985

publication

Expression in mammalian cells of the diaminopimelic acid decarboxylase of Escherichia coli permits cell growth in lysine-free medium

01 Dec 1984

publication

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

01 Nov 1984

publication

SV40-alpha-globulin hybrid minichromosomes. Differences in DNase I hypersensitivity of promoter and enhancer sequences

01 Nov 1984

publication

Tissue-specific expression is conferred by a sequence from the 5′ end of the rat albumin gene

25 Jul 1984

publication

Simian virus 40 illegitimate recombination occurs near short direct repeats

01 Jul 1984

publication

Papillomavirus genomes: sequences and consequences

01 Jun 1984

publication

Assembly of transfected DNA into chromatin: structural changes in the origin-promoter-enhancer region upon replication

01 Jan 1984

publication

Regulation of eukaryotic gene expression by transactivating proteins and cis acting DNA elements

01 Oct 1983

publication

Abundant excretion of human growth hormone by recombinant-plasmid-transformed monkey kidney cells

01 Jul 1983

publication

DNA replication origin of polyoma virus: early proximal boundary

01 Jun 1983

publication

Comparative studies of the expression of linked Escherichia coli gpt gene and BPV-1 DNAs in transfected cells

01 May 1983

publication

Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes

01 Jan 1983

publication

Structure and function of the promoter-enhancer region of polyoma and SV40

01 Oct 1982

publication

Deletions of N-terminal sequences of polyoma virus T-antigens reduce but do not abolish transformation of rat fibroblasts

15 Sep 1982

publication

Fine structure of the regulatory region of simian virus 40 minichromosomes revealed by DNAase I digestion

01 Sep 1982

publication

Physical and biological features of polyoma virus mutants able to infect embryonal carcinoma cell lines

01 Aug 1982

publication

Absence of nucleosomes in a histone-containing nucleoprotein complex obtained by dissociation of purified SV40 virions

01 May 1982

publication

Enhancing elements for activation of eukaryotic promoters

01 Jan 1982

publication

Both early and late control sequences of SV40 and polyoma promote transcription of Escherichia coli gpt gene in transfected cells

01 Jan 1982

publication

Human papillomavirus 1a complete DNA sequence: a novel type of genome organization among papovaviridae

01 Sep 1981

publication

Fine structure of the origin-proximal DNAase I-hypersensitive region in wild-type and EC mutant polyoma

15 Jul 1981

publication

A high-resolution electron microscopy study of nucleosomes from simian virus 40 chromatin

23 Apr 1981

publication

Polyoma DNA sequences involved in control of viral gene expression in murine embryonal carcinoma cells

23 Mar 1981

publication

[Chromatin structure with no nucleosomes: dissociated SV40 virus]

26 Jan 1981

publication

[Biochemical characteristics of a vaccine against hepatitis B]

24 Jan 1981

publication

Nucleotide sequence of the thrB gene of E. coli, and its two adjacent regions; the thrAB and thrBC junctions

01 Jan 1981

publication

Role of chromatin structure, histone acetylation, and the primary sequence of DNA in the expression of SV40 and polyoma in normal or teratocarcinoma cells

01 Nov 1980

publication

Escherichia coli RNA polymerase in vitro mimics simian virus 40 in vivo transcription when the template is viral nucleoprotein

01 Oct 1980

publication

Nucleotide sequence of the thrA gene of Escherichia coli

01 Aug 1980

publication

Molecular cloning, refined physical map and heterogeneity of methylation sites of papilloma virus type 1a DNA

01 Jun 1980

publication

Expression of polyoma early functions in mouse embryonal carcinoma cells depends on sequence rearrangements in the beginning of the late region

01 May 1980

publication

Localization of the binding sites of prokaryotic and eukaryotic RNA polymerases on simian virus 40 DNA

27 Feb 1980

publication

Sequential assembly of newly synthesized histones on replicating SV40 DNA

01 Jan 1980

publication

Coprecipitation of topoisomerase activity with simian virus 40 nucleoprotein complexes by divalent cations

10 Oct 1979

publication

Nicking-closing enzyme is associated with SV40 DNA in vivo as a sodium dodecyl sulfate-resistant complex

01 Aug 1979

publication

Construction and expression of a hybrid plasmid containing the Escherichia coli thrA and thrB genes

01 Aug 1979

publication

Nicking-closing enzyme assembles nucleosome-like structures in vitro

13 Jun 1979

publication

Comparative study of calf thymus and wheat germ RNA polymerase II: stability of initiation complexes and elongation rates

01 Jun 1979

publication

E. coli DNA binding protein HU forms nucleosomelike structure with circular double-stranded DNA

01 Apr 1979

publication

Effects of cytosol on transcription in isolated simian-virus-40-infected nuclei

01 Apr 1979

publication

Tropomyosin synthesis accompanies formation of actin filaments in embryonal carcinoma cells induced to differentiate by hexamethylene bisacetamide

01 Jan 1979

publication

Construction of hybrid viruses in vitro and their possible use for the production of specific viral or cellular proteins

01 Jan 1979

publication

Rapid turnover of acetyl groups in the four core histones of simian virus 40 minichromosomes

01 Jan 1979

publication

[Expression of ts-3 mutant of polyoma virus in mouse cells (author’s transl)]

01 Nov 1978

publication

Proteins bound to heterogeneous nuclear RNA of simian-virus-40-infected cells

01 Oct 1978

publication

Actin and tubulin in teratocarcinoma cells. Amount and intracellular organization upon cytodifferentiation

01 Sep 1978

publication

Transcription of polyoma virus DNA in vitro. III. Localization of calf thymus RNA polymerase II binding sites

01 Sep 1978

publication

Transcription of polyoma virus DNA in vitro. II. Transcription of superhelical and linear polyoma DNA by RNA polymerase II

01 Jan 1978

publication

Assembly of SV40 and polyoma minichromosomes during replication

01 Dec 1977

publication

Preferential association of newly synthesized histones with replicating SV40 DNA

01 Sep 1977

publication

Transcription of SV 40 nucleoprotein complexes in vitro

01 Mar 1977

publication

Human papillomavirus DNA: physical mapping of the cleavage sites of Bacillus amyloliquefaciens (BamI) and Haemophilus parainfluenzae (HpaII) endonucleases and evidence for partial heterogeneity

15 Feb 1977

publication

High resolution two-dimensional electrophoresis of proteins bound to heterogeneous nuclear RNA

01 Dec 1976

publication

Random location and absence of movement of the nucleosomes on SV 40 nucleoprotein complex isolated from infected cells

01 Nov 1976

publication

Transcription of polyoma virus DNA in vitro. Localization of Escherichia coli RNA polymerase initiation sites

12 Jul 1976

publication

Photosensitized splitting of thymine dimers in DNA by gene 32 protein from phage T 4

15 Dec 1975

publication

SV 40 nucleoprotein complexes: structural modifications after isopycnic centrifugation in metrizamide gradients

01 Dec 1975

publication

Human papillomavirus DNA: physical map

15 Sep 1975

publication

Location of the T4 gene 32 protein binding site on polyoma virus DNA

01 Sep 1975

publication

Denaturation map of polyoma DNA

10 May 1975

publication

The nucleotide sequences of the two glutamine transfer ribonucleic acids from Escherichia coli

01 Jan 1975

publication

Chromatin-like structures in polyoma virus and simian virus 10 lytic cycle

25 Jun 1974

publication

A single mutational modification of a tryptophan-specific transfer RNA permits aminoacylation by glutamine and translation of the codon UAG

23 Apr 1974

publication

Location of the T4 gene 32 protein-binding site on polyoma virus DNA

25 Feb 1973

publication

Nucleotide sequences from messenger RNA transcribed from the operator-proximal portion of the tryptophan operon of Escherichia coli

14 Nov 1972

publication

Comparative small-angle x-ray scattering studies on unacylated, acylated and cross-linked Escherichia coli transfer RNA I Val

01 Nov 1972

publication

Bidirectional transcription and the regulation of Phage lambda repressor synthesis

01 Oct 1971

publication

Introduction of an intramolecular flourescent pobe in E. coli tRNA(Val)(1)

22 Sep 1971

publication

Sequence relationship of three valine acceptor tRNAs from Escherichia coli

28 May 1971

publication

Fluorescence studies of interactions between Escherichia coli valyl-tRNA synthetase and its substrates

28 May 1971

publication

Photochemistry of 4-thiouridine in Escherichia coli transfer RNA1Val

28 May 1971

publication

Biological activity of irradiated tRNA Val containing a 4-thiouridine-cytosine dimer

01 Mar 1971

publication

Temperature-jump relaxation studies on transfer ribonucleic acids. Valine and tyrosine-specific tRNAs from Escherichia coli

01 Sep 1970

publication

Identification of sulfur-containing bases in transfer ribonucleic acids by phosphorescence spectroscopy

01 Sep 1970

publication

Presence of one polypeptide chain in valyl and isoleucyl tRNA synthetases from Escherichia coli

22 Oct 1969

publication

Fluorescence study of interactions between valyl- t RNA synthetase and valine-specific tRNA’s from Escherichia coli

01 Oct 1969

publication

The photochemistry of 4-thiouridine in Escherichia coli t-RNA Vał1

27 Sep 1969

publication

Structure of transfer RNA. Evidence for interaction between two non-adjacent nucleotide residues in tRNA from Escherichia coli

27 Sep 1969

publication

Molecular model for transfer RNA

28 Aug 1969

publication

Studies on valyl-tRNA synthetase and tRNA from Escherichia coli. II. Interaction between valyl-tRNA synthetase and valine acceptor tRNA

28 Aug 1969

publication

Studies on valyl-tRNA synthetase and tRNA from Escherichia coli. I. Purification and properties of the enzyme from normal Escherichia coli strains

28 Aug 1969

publication

Studies on valyl-tRNA synthetase and tRNA from Escherichia coli. 3. Valyl-tRNA synthetases from thermosensitive mutants of Escherichia coli

19 Apr 1969

publication

Nucleotide sequence of E. coli B tRNA1-Val

10 Jun 1968

publication

Phosphorescence from sulfur-containing bases in Escherichia coli t-RNA

29 Jan 1968

publication

[On the properties of a modified alanyl-t-RNA synthetase in a strain of escherichia coli with thermosensible growth]

22 Jan 1968

publication

[he modified properties of valyl-t-RNA synthetases in Escherichia coli mutants with thermosensitive growth]

21 Jun 1965

publication

[On the properties of valyl-sRNA synthetase in various thermosensitive Escherichia coli mutants]

01 Jan 1965

publication

A little guide for advanced search:

!!! CANCELLED !!! François Jacob & Jacques Monod Anniversary Symposium – Friday, June 19th, 2020 – Institut Pasteur, Paris

François Jacob Conference

130 Years of Institut Pasteur: Celebrating Science

EMBO Conference on Hijacking host signalling and epigenetic mimicry during infections

SEMINAR ” Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress “

Developmental and Stem Cell Biology & Neuroscience Departments joint seminars

With François Jacob, from temperature sensitive mutants of Escherichia coli to mouse development and diseases

Chromatin remodeling: from transcription to cancer

François Jacob (1920-2013)

The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis

The 50th anniversary of the publication of the operon theory in the Journal of Molecular Biology: past, present and future

Human papillomavirus type 8 E2 protein unravels JunB/Fra-1 as an activator of the beta4-integrin gene in human keratinocytes

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity

Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets

Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia

The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer

Small DNA tumour viruses and their contributions to our understanding of transcription control

Chromosomes and expression mechanisms: bringing together the roles of DNA, RNA and proteins

JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation

Deciphering AP-1 function in tumorigenesis: fra-ternizing on target promoters

Characterization of mammary tumors from Brg1 heterozygous mice

Dimer composition and promoter context contribute to functional cooperation between AP-1 and NFAT

Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription

Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation

JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation

Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex

The human SWI/SNF subunit Brm is a regulator of alternative splicing

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation

The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation

Alpha/beta interferon differentially modulates the clearance of cytoplasmic encapsidated replication intermediates and nuclear covalently closed circular hepatitis B virus (HBV) DNA from the livers of hepatocyte nuclear factor 1alpha-null HBV transgenic mice

Lack of JunD promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heart

A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network

SWI/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation

AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene

[Oxidative stress and angiogenesis: major role of AP-1]

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene

Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release

Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3

A transcriptional network in polycystic kidney disease

Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

JunD protects against chronic kidney disease by regulating paracrine mitogens

c-jun regulation and function in the developing hindbrain

HMG-I(Y) and the CBP/p300 coactivator are essential for human papillomavirus type 18 enhanceosome transcriptional activity

Impaired intervertebral disc formation in the absence of Jun

Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus

Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha

Promoter specificity and biological activity of tethered AP-1 dimers

Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta

Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression

SWI/SNF chromatin remodeling and cancer

Frequent alterations of the beta-catenin protein in cancer of the uterine cervix

A yeast homolog of chromatin assembly factor 1 is involved in early ribosome assembly

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

Chromatin modifiers and tumor suppression

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri

A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation

Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes

When the SWI/SNF complex remodels…the cell cycle

The mammalian Jun proteins: redundancy and specificity

Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity

The human brm protein is cleaved during apoptosis: the role of cathepsin G

Nuclear covalently closed circular viral genomic DNA in the liver of hepatocyte nuclear factor 1 alpha-null hepatitis B virus transgenic mice

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

An enhanceosome containing the Jun B/Fra-2 heterodimer and the HMG-I(Y) architectural protein controls HPV 18 transcription

JunD protects cells from p53-dependent senescence and apoptosis

HNF1alpha controls renal glucose reabsorption in mouse and man

Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression

Targeted disruption of the murine junD gene results in multiple defects in male reproductive function

Anatomy of a homeoprotein revealed by the analysis of human MODY3 mutations

Expression of the vHNF1/HNF1beta homeoprotein gene during mouse organogenesis

Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation

ATP-dependent chromatin remodelling: SWI/SNF and Co. are on the job

Retinal photoreceptors are apoptosis-competent in the absence of JunD/AP-1

Herniation of calcified intervertebral disk in a lumbar vertebral body presenting as acute scoliosis in a child. A case report and literature review

Papillomavirus E2 induces p53-independent apoptosis in HeLa cells

Rebuilding the road to cancer

The activity of mammalian brm/SNF2alpha is dependent on a high-mobility-group protein I/Y-like DNA binding domain