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© Research
Publication : EMBO reports

HNF1alpha controls renal glucose reabsorption in mouse and man

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in EMBO reports - 01 Oct 2000

Pontoglio M, Prié D, Cheret C, Doyen A, Leroy C, Froguel P, Velho G, Yaniv M, Friedlander G

Link to Pubmed [PMID] – 11269503

EMBO Rep. 2000 Oct;1(4):359-65

Recently it has been shown that dominant mutations in the human hepatocyte nuclear factor 1alpha (HNF1alpha) gene, encoding for a homeoprotein that is expressed in liver, kidney, pancreas and intestine, result in maturity onset diabetes of the young type 3 (MODY3). HNF1alpha-null mice are diabetic, but at the same time suffer from a renal Fanconi syndrome characterized by urinary glucose loss. Here we show that MODY3 patients are also characterized by a reduced tubular reabsorption of glucose. The renal murine defect is due to reduced expression of the low affinity/high capacity glucose cotransporter (SGLT2). Our results show that HNF1alpha directly controls SGLT2 gene expression. Together these data indicate that HNF1alpha plays a key role in glucose homeostasis in mammals.

http://www.ncbi.nlm.nih.gov/pubmed/11269503