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© Research
Publication : Nature structural & molecular biology

The human SWI/SNF subunit Brm is a regulator of alternative splicing

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature structural & molecular biology - 11 Dec 2005

Batsché E, Yaniv M, Muchardt C

Link to Pubmed [PMID] – 16341228

Nat. Struct. Mol. Biol. 2006 Jan;13(1):22-9

The SWI/SNF (mating-type switch/sucrose nonfermenting) complex involved in chromatin remodeling on promoters has also been detected on the coding region of genes. Here we show that SWI/SNF can function as a regulator of alternative splicing. We found that the catalytic subunit Brm favors inclusion of variant exons in the mRNA of several genes, including E-cadherin, BIM, cyclin D1 and CD44. Consistent with this, Brm associates with several components of the spliceosome and with Sam68, an ERK-activated enhancer of variant exon inclusion. Examination of the CD44 gene revealed that Brm induced accumulation of RNA polymerase II (RNAPII) with a modified CTD phosphorylation pattern on regions encoding variant exons. Altogether, our data suggest that on genes regulated by SWI/SNF, Brm contributes to the crosstalk between transcription and RNA processing by decreasing RNAPII elongation rate and facilitating recruitment of the splicing machinery to variant exons with suboptimal splice sites.

http://www.ncbi.nlm.nih.gov/pubmed/16341228