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© Research
Publication : The EMBO journal

Unregulated expression of c-Jun or c-Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The EMBO journal - 01 Aug 1991

Doucas V, Spyrou G, Yaniv M

Link to Pubmed [PMID] – 1906001

EMBO J. 1991 Aug;10(8):2237-45

We present evidence that oestrogen receptor activity in human MCF-7 breast cancer cells is reduced by over-expression of c-Jun or c-Fos proteins and to a lesser extent by Jun B overexpression. In contrast, overexpression of Jun D protein does not affect the activity of the oestrogen receptor. A region of c-Jun found to be required for repression of oestrogen receptor activity is located outside the DNA binding domain and is not conserved among the three Jun proteins. Finally, we suggest that c-Jun and c-Fos act independently to inactivate the oestrogen receptor.

http://www.ncbi.nlm.nih.gov/pubmed/1906001