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© Research
Publication : Molecular and cellular biology

The rat albumin promoter is composed of six distinct positive elements within 130 nucleotides

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular and cellular biology - 01 Nov 1989

Herbomel P, Rollier A, Tronche F, Ott MO, Yaniv M, Weiss MC

Link to Pubmed [PMID] – 2601696

Mol. Cell. Biol. 1989 Nov;9(11):4750-8

No fewer than six different positive regulatory elements concentrated within 130 base pairs constitute the rat albumin promoter, which drives highly tissue specific transcription in rat hepatoma cells in culture. Inactivation of each element led to a decrease in transcriptional efficiency: from upstream to downstream, 3- to 4-fold for distal elements III and II, 15-fold for distal element I, and 50-fold for the CCAAT box and the proximal element (PE). Three of these elements, distal elements III and II and, more crucially, the PE, were found to be involved in the tissue-specific character of transcription, with an additional negative regulation possibly superimposed at the level of the PE. Finally, our mapping of these regulatory elements in vivo entirely coincided with footprint data obtained in vitro, thereby allowing the tentative assignment of specific factors to the effects observed in vivo.

http://www.ncbi.nlm.nih.gov/pubmed/2601696