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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

Several distinct “CCAAT” box binding proteins coexist in eukaryotic cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 01 Feb 1988

Raymondjean M, Cereghini S, Yaniv M

Link to Pubmed [PMID] – 3422457

Proc. Natl. Acad. Sci. U.S.A. 1988 Feb;85(3):757-61

Even though a “CCAAT” box element is localized approximately equal to 80 base pairs upstream of the transcription initiation site in many eukaryotic promoters, it is not recognized by a single ubiquitous transcription factor. We show here that such a sequence present in the rat albumin promoter binds a protein distinct from the CCAAT-binding transcription factor CTF/NFI or from the CCAAT-binding protein (CBP) previously described. The protein binding to the albumin CCAAT sequence (ACF or albumin CCAAT factor) is not exclusive to liver, since we found a protein with identical properties in spleen.

http://www.ncbi.nlm.nih.gov/pubmed/3422457