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© Research
Publication : Cancer genetics

Chromatin remodeling: from transcription to cancer

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cancer genetics - 22 Mar 2014

Yaniv M

Link to Pubmed [PMID] – 24825771

Cancer Genet 2014 Sep;207(9):352-7

In this short review article, I have tried to trace the path that led my laboratory from the early studies of the structure of papova minichromosomes and transcription control to the investigation of chromatin remodeling complexes of the SWI/SNF family. I discuss briefly the genetic and biochemical studies that lead to the discovery of the SWI/SNF complex in yeast and drosophila and summarize some of the studies on the developmental role of the murine complex. The discovery of the tumor suppressor function of the SNF5/INI1/SMARCB1 gene in humans and the identification of frequent mutations in other subunits of this complex in different human tumors opened a fascinating field of research on this epigenetic regulator. The hope is to better understand tumor development and to develop novel treatments.

http://www.ncbi.nlm.nih.gov/pubmed/24825771