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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).
Publication : EMBO reports

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in EMBO reports - 01 Dec 2000

Klochendler-Yeivin A, Fiette L, Barra J, Muchardt C, Babinet C, Yaniv M

Link to Pubmed [PMID] – 11263494

EMBO Rep. 2000 Dec;1(6):500-6

The assembly of eukaryotic DNA into nucleosomes and derived higher order structures constitutes a barrier for transcription, replication and repair. A number of chromatin remodeling complexes, as well as histone acetylation, were shown to facilitate gene activation. To investigate the function of two closely related mammalian SWI/SNF complexes in vivo, we inactivated the murine SNF5/INI1 gene, a common subunit of these two complexes. Mice lacking SNF5 protein stop developing at the peri-implantation stage, showing that the SWI/SNF complex is essential for early development and viability of early embryonic cells. Furthermore, heterozygous mice develop nervous system and soft tissue sarcomas. In these tumors the wild-type allele was lost, providing further evidence that SNF5 functions as a tumor suppressor gene in certain cell types.

http://www.ncbi.nlm.nih.gov/pubmed/11263494