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© Research
Publication : The EMBO journal

Functional interference between the Spi-1/PU.1 oncoprotein and steroid hormone or vitamin receptors

Member: Moshe Yaniv
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The EMBO journal - 15 Dec 1993

Gauthier JM, Bourachot B, Doucas V, Yaniv M, Moreau-Gachelin F

Link to Pubmed [PMID] – 8262052

EMBO J. 1993 Dec;12(13):5089-96

The Spi-1/PU.1 protein is an Ets-related transcription factor, whose overexpression is a consequence of SFFV integration in Friend erythroleukemic cells. We present evidence that Spi-1/PU.1 can specifically repress the glucocorticoid-induced activation of promoters carrying a glucocorticoid response element (GRE). Conversely, the glucocorticoid receptor (GR) represses Spi-1/PU.1-mediated transcriptional activation in the presence of hormone. Spi-1/PU.1 also antagonized activation by other nuclear receptors, such as the thyroid hormone or the retinoic acid receptors, in several cell lines, including K562 erythroleukemic cells. These observations suggest that accumulation of the Spi-1/PU.1 protein may interfere with the action of hormones in the erythrocyte differentiation pathway.