Functional interference between the Spi-1/PU.1 oncoprotein and steroid hormone or vitamin receptors | Research - Institut Pasteur

A little guide for advanced search:

Tip 1. You can use quotes "" to search for an exact expression.
Example: "cell division"
Tip 2. You can use + symbol to restrict results containing all words.
Example: +cell +stem
Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
Example: +cell -stem

e.g. searching for members in projects tagged cancer

Search for

Count

IN

OUT

Content 1

Content Type

member
team
department
center
program_project
nrc
whocc
project
software
tool
patent

Keywords

Positions

Administrative Staff
Assistant Professor
Associate Professor
Clinical Research Assistant
Clinical Research Nurse
Clinician Researcher
Department Manager
Dual-education Student
Full Professor
Honorary Professor
Lab assistant
Master Student
Non-permanent Researcher
Nursing Staff
Permanent Researcher
Pharmacist
PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

Appointments

Deputy Director of Center
Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

Content 2

Content Type

member
team
department
center
program_project
nrc
whocc
project
software
tool
patent

Keywords

Positions

Administrative Staff
Assistant Professor
Associate Professor
Clinical Research Assistant
Clinical Research Nurse
Clinician Researcher
Department Manager
Dual-education Student
Full Professor
Honorary Professor
Lab assistant
Master Student
Non-permanent Researcher
Nursing Staff
Permanent Researcher
Pharmacist
PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

Appointments

Deputy Director of Center
Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

Search

EN
FR

Go back

Scroll to top

Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

Expression of the dystrophin-related protein (utrophin) gene during mouse embryogenesis.

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in The EMBO journal - 15 Dec 1993

Gauthier JM, Bourachot B, Doucas V, Yaniv M, Moreau-Gachelin F

Link to Pubmed [PMID] – 8262052

EMBO J. 1993 Dec;12(13):5089-96

The Spi-1/PU.1 protein is an Ets-related transcription factor, whose overexpression is a consequence of SFFV integration in Friend erythroleukemic cells. We present evidence that Spi-1/PU.1 can specifically repress the glucocorticoid-induced activation of promoters carrying a glucocorticoid response element (GRE). Conversely, the glucocorticoid receptor (GR) represses Spi-1/PU.1-mediated transcriptional activation in the presence of hormone. Spi-1/PU.1 also antagonized activation by other nuclear receptors, such as the thyroid hormone or the retinoic acid receptors, in several cell lines, including K562 erythroleukemic cells. These observations suggest that accumulation of the Spi-1/PU.1 protein may interfere with the action of hormones in the erythrocyte differentiation pathway.

Published on: 15 Dec 1993