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© Research
Publication : Oncogene

Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Oncogene - 01 Oct 1990

Castellazzi M, Dangy JP, Mechta F, Hirai S, Yaniv M, Samarut J, Lassailly A, Brun G

Link to Pubmed [PMID] – 2123532

Oncogene 1990 Oct;5(10):1541-7

The coding sequences of avian (quail) or murine c-jun proto-oncogenes were introduced into a non-defective retroviral vector derived from Rous sarcoma virus (RSV) in which c-jun replaces v-src. Primary avian fibroblasts chronically infected with either one of these viruses exhibit some phenotypic traits characteristic of RSV-transformed cells, including sustained growth in low serum medium and ability to develop colonies from single cells in agar, even though they are still of normal morphology and contact inhibited. This altered growth control correlates with enhanced AP1-specific DNA binding activity as well as with higher levels of c-Jun products. Unexpectedly, repression of the endogenous c-Jun product is observed in cells overexpressing murine c-Jun. Cells expressing the avian and the murine c-Jun products display qualitatively similar phenotypes; nevertheless, for every transformed trait considered, the murine c-jun seemed more potent than its quail homologue. These data suggest that the avian or murine c-jun proto-oncogenes may trigger a subset of the ‘transforming functions’ normally induced by v-src, and which are more specifically related to growth in low serum and in the absence of solid support.

http://www.ncbi.nlm.nih.gov/pubmed/2123532