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© Research
Publication : European journal of biochemistry / FEBS

Enhancer-mediated activation of a growth-regulated promoter

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of biochemistry / FEBS - 15 Jan 1987

Moore G, Yaniv M

Link to Pubmed [PMID] – 3026807

Eur. J. Biochem. 1987 Jan;162(2):333-8

We have demonstrated that the collagen alpha 2 type 1 promoter inserted in an expression vector, behaves as a growth-regulated promoter, which is consistent with previous observations that collagen synthesis is growth-regulated in vivo. In contrast, the activity of the H2-K or the simian virus 40 early promoters does not seem to be affected by the rate of cell proliferation. The insertion of a polyoma enhancer 5′ or 3′ to the collagen transcription unit activates the collagen alpha 2 type 1 promoter, by a threefold greater factor in slowly growing cells compared to cells growing exponentially. These results show that enhancers can also function in slowly proliferating cells and activate the normally low activity of a promoter in these cells.

http://www.ncbi.nlm.nih.gov/pubmed/3026807