Our unit studies the development and evolution of the brain. We develop mathematical models to better understand the origin of neocortical organisation, in particular, biophysical models of brain folding and connectivity. Our main animal model for the study of brain development is the ferret, whose first month after birth resembles the last trimester of gestation in humans – with a rich folding pattern and complex cortico-cortical connectivity. This line of research relies on multiple brain imaging modalities at different scales, such as whole-brain histology and magnetic resonance imaging. The results obtained through the theoretical and experimental analysis of brain development are used to study brain evolution, in particular, the evolution of the primate neocortex. Together, the study of evolution and development provide a conceptual framework for better understanding the variability of the human brain, allowing us to disentangling normal and pathological variation, in particular, within autism spectrum disorder. The study of neuroanatomical diversity relies on massive datasets with clinical, behavioural and cognitive data, whole-genome genotyping, and magnetic resonance imaging data for tens of thousands of individuals.
Autocomplete – Using wearables and ML to assist subjects with autism and their caretakers
Neurodevelopmental disorders(NDD) such as autism spectrum disorder (ASD), intellectual disability (ID). affect up to 15% of the population. These NDD produce disabilities which affect a person their whole life. In many cases, persons with […]
Tools for computational Neuroanatomy
We implement and develop data analysis pipelines to process large neuroimaging-genetics datasets, and participate in the analysis of several very large international consortia. We have developed online and offline interactive tools to examine the […]
Genomic architecture of normal and pathological human neuroanatomical diversity
Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Genome-wide scans looking for associations between genomic polymorphism and neuroanatomical variability identify, however, just a […]
Morphogenesis of neocortical organisation: theoretical and animal models
Neocortical folding is one of the most intriguing characteristics of the mammalian brain. Their pattern is very distinctive for different species, and there seems to be a remarkable relationship between convolutions and the architectonic […]
2023Diversity and evolution of cerebellar folding in mammals., Elife 2023 Sep; 12(): .
2022A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition., Cerebellum 2022 Nov; (): .
2022Insights from an autism imaging biomarker challenge: Promises and threats to biomarker discovery., Neuroimage 2022 Jul; 255(): 119171.
2022Brain charts for the human lifespan., Nature 2022 Apr; 604(7906): 525-533.
2022Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging., Neuron 2022 Jan; 110(1): 16-20.
2021Sex differences in the brain are not reduced to differences in body size., Neurosci Biobehav Rev 2021 11; 130(): 509-511.
2021Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?, Neuroimage 2021 Nov; 243(): 118502.
2021Neuroanatomical norms in the UK Biobank: The impact of allometric scaling, sex, and age., Hum Brain Mapp 2021 Oct; 42(14): 4623-4642.
2021Centering inclusivity in the design of online conferences-An OHBM-Open Science perspective., Gigascience 2021 Aug; 10(8): .
2021Brainhack: Developing a culture of open, inclusive, community-driven neuroscience., Neuron 2021 Jun; 109(11): 1769-1775.
+View full list of publications