The team works on the underlying molecular mechanisms of the progeroid disease Cockayne syndrome and their link with physiological ageing. We focus on the role of oxidative and nitrosative stress, epigenetic alterations, and mitochondrial dysfunction in pathophysiological ageing. This disease is clinically very heterogeneous and is poorly recapitulated in animal models. For this, we study cells derived from multiple patients with different clinical severity, and patient-derived induced pluripotent stem cells (iPSCs) and cerebral organoids. We have also generated isogenic cellular models to study genotype/phenotype correlations that remain elusive to date. Our team has also experience in DNA repair.
